PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT7	1	BEND3	4	affinity chromatography technology	Tsai YC (2012)	1
EED	1	CBX8	3	affinity chromatography technology	Cao Q (2014)	1
SIRT7	1	DNMT1	5	affinity chromatography technology	Tsai YC (2012)	1
DNMT1	5	DNMT3B	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Lehnertz B (2003), Kim GD (2002), Kim GD (2002), Geiman TM (2004), Woloszynska-Read A (2007), OHagan HM (2011), Rigbolt KT (2011)	7
HIST1H4A	0	HDAC1	4	pull down, pull down, affinity chromatography technology	Shiio Y (2003), Li X (2014), Hein MY (2015)	3
HDAC1	4	BEND3	4	affinity chromatography technology	Joshi P (2013)	1
KIAA1107	3	BAZ2A	4	affinity chromatography technology	Hein MY (2015)	1
USP21	2	BEND3	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Khan A (2015)	2
EED	1	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
BAZ2A	4	HDAC1	4	pull down, affinity chromatography technology	Zhou Y (2005), Hein MY (2015)	2
BEND3	4	SMARCA5	4	affinity chromatography technology, affinity chromatography technology	Khan A (2015), Khan A (2015)	2
CBX8	3	26148	0	affinity chromatography technology	Hein MY (2015)	1
SMARCA5	4	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alenghat T (2006), Alenghat T (2006), Loyola A (2001)	3
IFI16	1	SMARCA5	4	affinity chromatography technology	Diner BA (2015)	1
BAZ2A	4	HIST1H4A	0	pull down, unspecified method	Zhou Y (2005), Zhou Y (2005)	2
BAZ2A	4	DNMT1	5	pull down	Zhou Y (2005)	1
26148	0	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Hauri S (2016)	3
DNMT3B	3	HDAC1	4	biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Geiman TM (2004), Suzuki M (2006), Geiman TM (2004), Geiman TM (2004), Cai Y (2014)	5
TTF1	3	BAZ2A	4	pull down, two hybrid	Nemeth A (2004), Nemeth A (2004)	2
BAZ2A	4	USP21	2	affinity chromatography technology	Khan A (2015)	1
KAT8	2	HIST1H4A	0	enzymatic study, affinity chromatography technology, imaging technique, enzymatic study	Smith ER (2005), Zippo A (2009), Zippo A (2009), Tropberger P (2013)	4
SIRT7	1	HIST1H4A	0	pull down	Ford E (2006)	1
HDAC1	4	SMARCA5	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
EED	1	BAZ2A	4	affinity chromatography technology	Cao Q (2014)	1
26148	0	BAZ2A	4	affinity chromatography technology	Hein MY (2015)	1
KAT8	2	BAZ2A	4	enzymatic study, affinity chromatography technology	Zhou Y (2009), Zhou Y (2009)	2
EED	1	DNMT1	5	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
RACGAP1	2	BAZ2A	4	affinity chromatography technology	Hein MY (2015)	1
EED	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Hein MY (2015)	4
DNMT3B	3	SMARCA5	4	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Geiman TM (2004), Geiman TM (2004), Geiman TM (2004), Geiman TM (2004), Geiman TM (2004)	5
BEND3	4	BAZ2A	4	affinity chromatography technology, affinity chromatography technology	Khan A (2015), Khan A (2015)	2
CBX8	3	BAZ2A	4	affinity chromatography technology	Hein MY (2015)	1
BAZ2A	4	DNMT3B	3	pull down	Zhou Y (2005)	1
EED	1	DNMT3B	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
DNMT1	5	HDAC1	4	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Robertson KD (2000), Achour M (2008), Achour M (2008), Kimura H (2003), Zhang Q (2005), Myant K (2008), Schnekenburger M (2007), Kang KA (2012), Cui S (2011), Cui S (2011), Hervouet E (2010), Cai Y (2014), Cai Y (2014), Yuan K (2016), Yuan K (2016)	15
BAZ2A	4	SMARCA5	4	pull down, affinity chromatography technology, affinity chromatography technology	Strohner R (2001), Zhou Y (2009), Zhou Y (2005)	3
IFI16	1	BAZ2A	4	affinity chromatography technology	Diner BA (2015)	1
SIRT7	1	BAZ2A	4	affinity chromatography technology	Tsai YC (2012)	1
IFI16	1	RACGAP1	2	affinity chromatography technology	Diner BA (2015)	1
SIRT7	1	TTF1	3	affinity chromatography technology	Tsai YC (2012)	1
DNMT1	5	SMARCA5	4	affinity chromatography technology, affinity chromatography technology	Robertson AK (2004), Robertson AK (2004)	2