PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	BMI1	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
H2AFX	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Lee HS (2010), Yang X (2010)	3
FOXE1	2	MECP2	36	affinity chromatography technology	Li X (2015)	1
HIST1H3A	3	MECP2	36	bioid	Lambert JP (2015)	1
HIST1H3A	3	HIST1H2BB	3	affinity chromatography technology	Klement K (2014)	1
SMARCAD1	1	XRCC6	3	affinity chromatography technology	Rowbotham SP (2011)	1
NCOR1	9	SMARCA2	17	biochemical	Havugimana PC (2012)	1
SUMO2	0	XRCC6	3	pull down	Ouyang J (2009)	1
ELAVL1	0	TEAD2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HIST1H4A	0	HIST1H2BB	3	affinity chromatography technology	Klement K (2014)	1
GRK5	7	XRCC5	5	affinity chromatography technology	Wu Z (2012)	1
RBBP4	3	XRCC6	3	two hybrid	Stelzl U (2005)	1
TEAD2	2	SATB1	1	affinity chromatography technology	Li X (2015)	1
MAX	0	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
SMARCA2	17	MECP2	36	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Harikrishnan KN (2005), Harikrishnan KN (2005), Harikrishnan KN (2005), Vecsler M (2010)	4
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
BAZ1A	5	RBBP4	3	biochemical	Havugimana PC (2012)	1
MAX	0	MECP2	36	affinity chromatography technology	Li X (2015)	1
BMI1	0	SMARCA2	17	affinity chromatography technology	Cao Q (2014)	1
TEAD2	2	BAZ1A	5	affinity chromatography technology	Li X (2015)	1
SMARCA5	4	BAZ1B	5	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bozhenok L (2002), Cavellan E (2006), Cavellan E (2006), Cavellan E (2006), Havugimana PC (2012), Sarshad A (2013), Sarshad A (2013)	7
UGGT1	6	BAZ1A	5	affinity chromatography technology	Hein MY (2015)	1
SMARCA5	4	SATB1	1	pull down, pull down	Yasui D (2002), Yasui D (2002)	2
HIST1H3A	3	NCOR1	9	pull down	Yu J (2003)	1
SUMO2	0	BAZ1A	5	pull down	Ouyang J (2009)	1
NCOR1	9	HIST1H4A	0	pull down	Hartman HB (2005)	1
BMI1	0	HIST1H2BB	3	affinity chromatography technology	Cao Q (2014)	1
FOXE1	2	SATB1	1	affinity chromatography technology	Li X (2015)	1
SMARCAD1	1	BAZ1A	5	affinity chromatography technology	Rowbotham SP (2011)	1
ELAVL1	0	MECP2	36	affinity chromatography technology	Abdelmohsen K (2009)	1
CCDC22	1	BAZ1A	5	affinity chromatography technology	Hein MY (2015)	1
SMAD9	0	BAZ1A	5	two hybrid	Colland F (2004)	1
TEAD2	2	MECP2	36	affinity chromatography technology	Li X (2015)	1
BAZ1A	5	HIST1H3A	3	affinity chromatography technology	Klement K (2014)	1
HIST1H3A	3	BAZ1B	5	imaging technique	Soldi M (2013)	1
SMARCA5	4	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alenghat T (2006), Alenghat T (2006), Loyola A (2001)	3
SRPK2	1	XRCC5	5	enzymatic study	Lipp JJ (2015)	1
XRCC5	5	SMARCA5	4	affinity chromatography technology	Lan L (2010)	1
FOXL1	0	SATB1	1	affinity chromatography technology	Li X (2015)	1
H2AFX	1	BMI1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ginjala V (2011), Pan MR (2011), Pan MR (2011), Pan MR (2011)	4
NCOR1	9	RBBP4	3	biochemical	Havugimana PC (2012)	1
HIST1H4A	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Saade E (2009), Verreault A (1996), Huttlin EL (2017), Millard CJ (2016), Kleiner RE (2018)	5
CCDC8	1	BAZ1A	5	affinity chromatography technology	Hanson D (2014)	1
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
RHOA	0	SMAD2	5	pull down	Miyamoto-Sato E (2010)	1
CAPN6	0	CHRAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
BMI1	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Facchino S (2010), Cao Q (2014)	2
MECP2	36	NCOR1	9	pull down, pull down	Kokura K (2001), Kokura K (2001)	2
SMAD2	5	BAZ1A	5	two hybrid	Colland F (2004)	1
HIST1H3A	3	SMARCA2	17	pull down, pull down	Lavigne M (2009), Lavigne M (2009)	2
RHOA	0	BAZ1A	5	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
XRCC5	5	CHRAC1	0	affinity chromatography technology	Lan L (2010)	1
XRCC5	5	BAZ1A	5	affinity chromatography technology, pull down	Lan L (2010), Lan L (2010)	2
BMI1	0	SRPK2	1	affinity chromatography technology	Cao Q (2014)	1
BAZ1A	5	H2AFX	1	affinity chromatography technology	Klement K (2014)	1
BAZ1A	5	SMARCA2	17	affinity chromatography technology	He X (2006)	1
SUMO2	0	BAZ1B	5	pull down	Ouyang J (2009)	1
BAZ1A	5	HIST1H2BB	3	affinity chromatography technology	Klement K (2014)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
SMAD9	0	SMAD2	5	two hybrid	Colland F (2004)	1
CAPN6	0	BAZ1A	5	affinity chromatography technology	Huttlin EL (2017)	1
MTNR1A	1	BAZ1A	5	two hybrid	Benleulmi-Chaachoua A (2016)	1
BMI1	0	BAZ1B	5	affinity chromatography technology	Abdouh M (2016)	1
H2AFX	1	ELAVL1	0	affinity chromatography technology	Yang X (2010)	1
XRCC6	3	BAZ1A	5	pull down	Lan L (2010)	1
MECP2	36	BAZ1A	5	affinity chromatography technology	Huttlin EL (2017)	1
FOXE1	2	BAZ1A	5	affinity chromatography technology	Li X (2015)	1
CCDC8	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Hanson D (2014)	2
CCDC8	1	BAZ1B	5	affinity chromatography technology	Hanson D (2014)	1
SUMO2	0	XRCC5	5	pull down	Ouyang J (2009)	1
BMI1	0	HIST1H3A	3	affinity chromatography technology	Abdouh M (2016)	1
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
BAZ1A	5	HIST1H4A	0	affinity chromatography technology	Klement K (2014)	1
SMARCA2	17	RBBP4	3	biochemical, affinity chromatography technology	Sif S (2001), Nakamura T (2002)	2
SMARCAD1	1	XRCC5	5	affinity chromatography technology	Rowbotham SP (2011)	1
XRCC5	5	POLE3	0	affinity chromatography technology	Lan L (2010)	1
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CHRAC1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
SMARCA5	4	HIST1H3A	3	affinity chromatography technology, pull down, imaging technique	Loyola A (2001), Kouskouti A (2005), Soldi M (2013)	3
POLE3	0	BAZ1A	5	affinity chromatography technology, pull down, pull down	Poot RA (2000), Kukimoto I (2004), Kukimoto I (2004)	3
FOXL1	0	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
POLE3	0	CHRAC1	0	affinity chromatography technology, pull down, two hybrid, biochemical, two hybrid	Poot RA (2000), Poot RA (2000), Rolland T (2014), Wan C (2015), Yu H (2011)	5
BMI1	0	BAZ1A	5	affinity chromatography technology	Abdouh M (2016)	1
GRK5	7	BAZ1A	5	affinity chromatography technology	Wu Z (2012)	1
SMARCA5	4	POLE3	0	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Poot RA (2000), Poot RA (2000), Poot RA (2000), Kukimoto I (2004), Wan C (2015)	5
SMARCA5	4	CHRAC1	0	biochemical, affinity chromatography technology, pull down, biochemical, biochemical	Poot RA (2000), Poot RA (2000), Kukimoto I (2004), Havugimana PC (2012), Wan C (2015)	5
NCOR1	9	BAZ1A	5	two hybrid, pull down, affinity chromatography technology	Ewing AK (2007), Ewing AK (2007), Ewing AK (2007)	3
FOXL1	0	BAZ1A	5	affinity chromatography technology	Li X (2015)	1
SMARCA5	4	RBBP4	3	biochemical, biochemical, biochemical	Hakimi MA (2002), Havugimana PC (2012), Wan C (2015)	3
SATB1	1	BAZ1A	5	biochemical, pull down, pull down	Yasui D (2002), Yasui D (2002), Yasui D (2002)	3
HIST1H3A	3	XRCC6	3	affinity chromatography technology, bioid	Fnu S (2011), Lambert JP (2015)	2
CCDC8	1	SMARCA5	4	affinity chromatography technology	Hanson D (2014)	1
BAZ1A	5	BAZ1B	5	biochemical	Bozhenok L (2002)	1
MAX	0	BAZ1A	5	affinity chromatography technology	Li X (2015)	1
BAZ1A	5	CHRAC1	0	pull down, pull down	Kukimoto I (2004), Kukimoto I (2004)	2
FOXL1	0	SMARCAD1	1	affinity chromatography technology	Li X (2015)	1
BMI1	0	SMARCA5	4	affinity chromatography technology	Cao Q (2014)	1
TEAD2	2	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
CCDC8	1	ELAVL1	0	affinity chromatography technology	Hanson D (2014)	1
SRPK2	1	BAZ1A	5	enzymatic study	Lipp JJ (2015)	1
MTNR1A	1	BAZ1B	5	two hybrid	Benleulmi-Chaachoua A (2016)	1
H2AFX	1	SMARCA2	17	affinity chromatography technology, affinity chromatography technology	Park JH (2006), Lee HS (2010)	2
ELAVL1	0	BAZ1A	5	affinity chromatography technology	Abdelmohsen K (2009)	1
CCDC8	1	XRCC6	3	affinity chromatography technology	Hanson D (2014)	1
SMARCAD1	1	SMARCA5	4	affinity chromatography technology	Rowbotham SP (2011)	1
SMARCA5	4	BAZ1A	5	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bochar DA (2000), Bochar DA (2000), Poot RA (2000), Poot RA (2000), Bozhenok L (2002), Bozhenok L (2002), Yasui D (2002), Yasui D (2002), Hakimi MA (2002), LeRoy G (2000), LeRoy G (2000), LeRoy G (2000), Klement K (2014), Klement K (2014)	14
HIST1H3A	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Wysocka J (2006), Nishioka K (2002), Tagami H (2004), Foltz DR (2009), Millard CJ (2016)	5
SUMO2	0	RBBP4	3	pull down	Ouyang J (2009)	1
FOXE1	2	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
CCDC8	1	UGGT1	6	affinity chromatography technology	Hanson D (2014)	1