PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANXA7	0	PCBP1	2	biochemical	Wan C (2015)	1
CDKN1A	1	TLE1	6	two hybrid	Vinayagam A (2011)	1
ANXA7	0	ERG28	0	two hybrid	Vinayagam A (2011)	1
RBFOX1	1	MKRN1	1	affinity chromatography technology	Huttlin EL (2017)	1
CELF3	2	CELF5	2	affinity chromatography technology	Huttlin EL (2017)	1
CELF3	2	SOBP	2	two hybrid	Stelzl U (2005)	1
RBFOX1	1	CELF3	2	two hybrid	Lim J (2006)	1
CELF3	2	MKRN1	1	affinity chromatography technology	Huttlin EL (2017)	1
ANXA7	0	TLE1	6	two hybrid	Vinayagam A (2011)	1
CELF3	2	ERG28	0	two hybrid	Stelzl U (2005)	1
CDKN1A	1	CELF3	2	two hybrid	Vinayagam A (2011)	1
PCBP1	2	CELF3	2	two hybrid	Lim J (2006)	1
ANXA7	0	CELF3	2	two hybrid	Vinayagam A (2011)	1
CELF3	2	TLE1	6	two hybrid	Stelzl U (2005)	1
CDKN1A	1	MKRN1	1	affinity chromatography technology, affinity chromatography technology	Lee EW (2009), Lee EW (2009)	2