PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DIABLO	2	UBE2K	0	affinity chromatography technology, pull down, affinity chromatography technology	Bae Y (2010), Bae Y (2010), Bae Y (2010)	3
CASP9	6	BIRC8	0	pull down, two hybrid, affinity chromatography technology	Richter BW (2001), Rolland T (2014), Huttlin EL (2017)	3
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2K	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D3	1	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2W	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D4	0	XIAP	0	two hybrid	Markson G (2009)	1
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HTRA2	1	XIAP	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, unspecified method, pull down	Hegde R (2003), Verhagen AM (2002), Hao Y (2004), Sekine K (2005), Vucic D (2002), van Loo G (2002), Seong YM (2004), Seong YM (2004), Martins LM (2002), Martins LM (2002), Suzuki Y (2001), Suzuki Y (2001), Hegde R (2002), Plun-Favreau H (2007), Singh N (2014), Singh N (2014), Singh N (2014)	17
XIAP	0	UBE2E1	1	two hybrid, pull down	Dynek JN (2010), Markson G (2009)	2
BIRC8	0	CDK19	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
UBE2G2	0	BIRC8	0	two hybrid	van Wijk SJ (2009)	1
XIAP	0	MAGED1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jordan BW (2001), Jordan BW (2001), Jordan BW (2001), Kang J (2014)	4
BIRC8	0	GLUD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
FAM107A	0	BIRC8	0	two hybrid	Mu P (2017)	1
HTRA2	1	DIABLO	2	far western blotting, affinity chromatography technology	Hegde R (2002), Hegde R (2002)	2
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
UBE2E1	1	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
UBE2D4	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
UBE2W	0	XIAP	0	two hybrid, two hybrid	Markson G (2009), Dynek JN (2010)	2
BIRC8	0	DIABLO	2	x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Shin H (2005), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
MAGED1	0	BIRC8	0	two hybrid	Rolland T (2014)	1
UBE2V1	0	BIRC8	0	two hybrid	Markson G (2009)	1
BIRC8	0	HTRA2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
UBE2D1	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D2	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D3	1	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Bartke T (2004), Bornstein B (2011), Damgaard RB (2013), Markson G (2009)	7
UBE2N	1	BIRC8	0	two hybrid	Markson G (2009)	1