PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELL	4	SNF8	2	pull down, affinity chromatography technology, pull down	Schmidt AE (1999), Mathews A (2009), Mathews A (2009)	3
VPS36	3	WDR12	0	biochemical	Kristensen AR (2012)	1
GTF2E1	1	RPUSD2	1	biochemical	Kristensen AR (2012)	1
HAT1	0	SNF8	2	biochemical	Wan C (2015)	1
DUS3L	5	SNF8	2	biochemical	Kristensen AR (2012)	1
EFTUD2	12	RPUSD2	1	biochemical	Kristensen AR (2012)	1
PSMD3	5	SNF8	2	biochemical	Wan C (2015)	1
METTL14	4	SNF8	2	biochemical	Havugimana PC (2012)	1
UBL7	0	SNF8	2	biochemical	Wan C (2015)	1
ACBD3	1	VPS36	3	biochemical	Kristensen AR (2012)	1
SNF8	2	CHMP6	0	two hybrid, two hybrid	Bowers K (2006), von Schwedler UK (2003)	2
GTF2E1	1	HARS	0	biochemical	Kristensen AR (2012)	1
RPUSD2	1	SNF8	2	biochemical	Kristensen AR (2012)	1
ADORA1	2	SNF8	2	two hybrid	Wang J (2011)	1
TTC1	3	HARS	0	biochemical	Kristensen AR (2012)	1
VPS28	2	VPS25	1	affinity chromatography technology, affinity chromatography technology	Im YJ (2008), Medina GN (2011)	2
DUS3L	5	EFTUD2	12	biochemical	Kristensen AR (2012)	1
VPS28	2	NIF3L1	0	biochemical	Wan C (2015)	1
VPS36	3	CHMP6	0	two hybrid	von Schwedler UK (2003)	1
ACBD3	1	RPUSD2	1	biochemical	Kristensen AR (2012)	1
ACBD3	1	HARS	0	biochemical	Kristensen AR (2012)	1
VPS25	1	VPS36	3	two hybrid, two hybrid, pull down, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	12
SNF8	2	GTF2F1	0	biochemical	Kristensen AR (2012)	1
VPS28	2	SNF8	2	affinity chromatography technology	Im YJ (2008)	1
BCAT1	6	PRMT6	2	two hybrid	Weimann M (2013)	1
SNF8	2	VAC14	5	two hybrid	Rolland T (2014)	1
SNF8	2	TLN2	10	biochemical	Wan C (2015)	1
VPS36	3	TSG101	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Kumar B (2016), Kumar B (2016)	5
SNF8	2	TSG101	1	two hybrid, two hybrid, two hybrid	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003)	3
WDR12	0	RPUSD2	1	biochemical	Kristensen AR (2012)	1
TTC1	3	EFTUD2	12	biochemical	Kristensen AR (2012)	1
SNF8	2	SNF8	2	two hybrid, two hybrid, two hybrid	Bowers K (2006), Langelier C (2006), von Schwedler UK (2003)	3
EFTUD2	12	SNF8	2	biochemical	Kristensen AR (2012)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
UBA6	4	SNF8	2	biochemical	Wan C (2015)	1
SNF8	2	VPS36	3	two hybrid, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Wan C (2015), Huttlin EL (2017)	9
TSG101	1	WDR12	0	biochemical	Havugimana PC (2012)	1
GOLGA2	2	VPS28	2	two hybrid	Rolland T (2014)	1
VPS25	1	WDR12	0	biochemical	Kristensen AR (2012)	1
SNF8	2	RBP1	1	pull down, affinity chromatography technology	Mathews A (2009), Mathews A (2009)	2
YWHAE	0	SNF8	2	pull down, affinity chromatography technology	Satoh J (2006), Satoh J (2006)	2
SNF8	2	NIF3L1	0	two hybrid	Rual JF (2005)	1
ACBD3	1	WDR12	0	biochemical	Kristensen AR (2012)	1
BCAT1	6	KDM1A	2	two hybrid	Weimann M (2013)	1
NUDCD3	0	SNF8	2	biochemical	Havugimana PC (2012)	1
TSG101	1	VPS28	2	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stuchell MD (2004), Bishop N (2001), von Schwedler UK (2003), Martin-Serrano J (2003), Stefani F (2011), Venkatesan K (2009), Wunderley L (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
GTF2E1	1	TTC1	3	biochemical	Kristensen AR (2012)	1
TTC1	3	SNF8	2	biochemical	Kristensen AR (2012)	1
VPS25	1	CHMP6	0	two hybrid, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down	Bowers K (2006), Bowers K (2006), Langelier C (2006), Langelier C (2006), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Tsang HT (2006), Yorikawa C (2005), Yorikawa C (2005)	10
MCM2	3	HARS	0	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	SNF8	2	two hybrid, pull down, affinity chromatography technology	Mathews A (2009), Mathews A (2009), Mathews A (2009)	3
RILP	0	SNF8	2	pull down	Wang T (2006)	1
GTF2E1	1	EFTUD2	12	biochemical	Kristensen AR (2012)	1
DUS3L	5	BCAT1	6	biochemical	Kristensen AR (2012)	1
HAT1	0	TLN2	10	biochemical	Wan C (2015)	1
TSG101	1	NIF3L1	0	biochemical	Wan C (2015)	1
HARS	0	RPUSD2	1	biochemical	Kristensen AR (2012)	1
GTF2F1	0	GTF2E1	1	biochemical, pull down, pull down, affinity chromatography technology	Scully R (1997), Scully R (1997), Maxon ME (1994), Cujec TP (1997)	4
ACBD3	1	SNF8	2	biochemical	Kristensen AR (2012)	1
GTF2E1	1	ACBD3	1	biochemical	Kristensen AR (2012)	1
VPS28	2	VPS36	3	affinity chromatography technology, x-ray crystallography	Im YJ (2008), Gill DJ (2007)	2
DUS3L	5	GTF2F1	0	biochemical	Kristensen AR (2012)	1
DVL2	5	SNF8	2	two hybrid	Rual JF (2005)	1
MCM2	3	PSMD3	5	affinity chromatography technology	Drissi R (2015)	1
RILP	0	VPS36	3	pull down	Wang T (2006)	1
MCM2	3	ELL	4	pull down	Mathews A (2009)	1
ACBD3	1	EFTUD2	12	biochemical	Kristensen AR (2012)	1
ACBD3	1	DUS3L	5	biochemical	Kristensen AR (2012)	1
TTC1	3	RPUSD2	1	biochemical	Kristensen AR (2012)	1
SNF8	2	VPS25	1	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, two hybrid	Rual JF (2005), Bowers K (2006), Bowers K (2006), Bowers K (2006), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Rolland T (2014), Wan C (2015), Yu H (2011)	11
WDR12	0	SNF8	2	biochemical	Kristensen AR (2012)	1
HARS	0	SNF8	2	biochemical	Kristensen AR (2012)	1
SNF8	2	SUV39H2	3	two hybrid	Weimann M (2013)	1
SNF8	2	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BCAT1	6	SNF8	2	biochemical	Kristensen AR (2012)	1
GOLGA2	2	SNF8	2	two hybrid	Rolland T (2014)	1
KDM1A	2	TRIM54	1	two hybrid	Rolland T (2014)	1
SNF8	2	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BCAT1	6	GTF2F1	0	biochemical	Kristensen AR (2012)	1
MCM2	3	YWHAE	0	affinity chromatography technology	Drissi R (2015)	1
HARS	0	EFTUD2	12	biochemical	Kristensen AR (2012)	1
SNF8	2	TRIM54	1	two hybrid	Rolland T (2014)	1
VPS28	2	TRIM54	1	two hybrid	Rolland T (2014)	1
TSG101	1	CHMP6	0	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2
GTF2E1	1	SNF8	2	biochemical	Kristensen AR (2012)	1
UBL7	0	TLN2	10	biochemical	Wan C (2015)	1