Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRM2 1129 DAROTROPIUM BROMIDE CHEMBL2103803 antagonist ChemblInteractions
CHRM2 1129 PROPIOMAZINE CHEMBL1201210 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 BROMPHENIRAMINE CHEMBL811 antagonist DrugBank 10212017
CHRM2 1129 CHLORPROTHIXENE CHEMBL908 antagonist DrugBank 7855217
CHRM2 1129 PIPECURONIUM CHEMBL1201206 antagonist DrugBank 10598601, 12426786, 10592235
CHRM2 1129 FESOTERODINE CHEMBL1201764 antagonist TEND, DrugBank 19029429
CHRM2 1129 UMECLIDINIUM CHEMBL1187833 antagonist GuideToPharmacologyInteractions, DrugBank 23435542
CHRM2 1129 ARECOLINE CHEMBL7303 agonist GuideToPharmacologyInteractions
CHRM2 1129 BRUCINE CHEMBL501756 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 GALLAMINE CHEMBL360055 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL1256845 CHEMBL1256845 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 VINBURNINE CHEMBL1892145 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 VINCAMINE CHEMBL1165342 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 SALICYLIC ACID CHEMBL424 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 AMITRIPTYLINE CHEMBL629 antagonist GuideToPharmacologyInteractions
CHRM2 1129 DEXETIMIDE CHEMBL1908364 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL1233686 CHEMBL1233686 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL1628667 CHEMBL1628667 antagonist GuideToPharmacologyInteractions
CHRM2 1129 Afacifenacin CHEMBL3545165 antagonist ChemblInteractions
CHRM2 1129 PROPANTHELINE BROMIDE CHEMBL1240 antagonist ChemblInteractions
CHRM2 1129 BETHANECHOL CHLORIDE CHEMBL1768 agonist ChemblInteractions
CHRM2 1129 ROCURONIUM CHEMBL1201244 TdgClinicalTrial, TEND
CHRM2 1129 HOMATROPINE METHYLBROMIDE CHEMBL1200851 TdgClinicalTrial, TEND
CHRM2 1129 CLOZAPINE CHEMBL42 antagonist DrugBank 17848919
CHRM2 1129 LOXAPINE CHEMBL831 binder DrugBank
CHRM2 1129 HYOSCYAMINE CHEMBL1331216 antagonist DrugBank 17139284, 17016423, 11495349
CHRM2 1129 GALLAMINE TRIETHIODIDE CHEMBL1200993 antagonist DrugBank, TTD 17944454, 11752352, 20083608, 17588565, 15937215, 18552124, 11426849, 7522861, 18305010, 9007524
CHRM2 1129 TRIFLUPROMAZINE CHEMBL570 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 4152054
CHRM2 1129 ANISOTROPINE METHYLBROMIDE CHEMBL1578 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 4555460
CHRM2 1129 MIVACURIUM CHEMBL1182833 partial agonist, antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 DIPHENIDOL CHEMBL936 antagonist TdgClinicalTrial, TEND, DrugBank 9851542, 1863523, 10497897, 9454790, 12185001, 10530931, 9059856, 8050463
CHRM2 1129 LEVOMEPROMAZINE CHEMBL1764 antagonist TdgClinicalTrial, TEND, DrugBank 2870716, 2899826
CHRM2 1129 ACLIDINIUM CHEMBL1194325 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank
CHRM2 1129 ARECAIDINE PROPARGYL ESTER CHEMBL128365 agonist GuideToPharmacologyInteractions
CHRM2 1129 BETHANECHOL CHEMBL1482 agonist GuideToPharmacologyInteractions
CHRM2 1129 5-METHYLFURMETHIODIDE CHEMBL1316369 agonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL99521 CHEMBL99521 agonist GuideToPharmacologyInteractions
CHRM2 1129 OXOTREMORINE CHEMBL7634 agonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL343796 CHEMBL343796 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 4-DAMP CHEMBL76897 antagonist GuideToPharmacologyInteractions
CHRM2 1129 IPRATROPIUM CHEMBL1621597 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
CHRM2 1129 METHOCTRAMINE CHEMBL27673 antagonist GuideToPharmacologyInteractions
CHRM2 1129 OTENZEPAD CHEMBL17045 antagonist GuideToPharmacologyInteractions
CHRM2 1129 COENZYME_A CHEMBL1213327 antagonist GuideToPharmacologyInteractions
CHRM2 1129 TIOTROPIUM (CHEMBL1900528) CHEMBL1900528 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
CHRM2 1129 PROMETHAZINE CHEMBL643 TdgClinicalTrial, TEND
CHRM2 1129 SOLIFENACIN SUCCINATE CHEMBL1200803 antagonist ChemblInteractions
CHRM2 1129 FESOTERODINE FUMARATE CHEMBL1201765 antagonist ChemblInteractions
CHRM2 1129 DARIFENACIN HYDROBROMIDE CHEMBL1200935 antagonist ChemblInteractions
CHRM2 1129 THIETHYLPERAZINE CHEMBL1378 TdgClinicalTrial, TEND
CHRM2 1129 DESIPRAMINE CHEMBL72 TdgClinicalTrial, TEND
CHRM2 1129 BATEFENTEROL CHEMBL3039518 antagonist ChemblInteractions
CHRM2 1129 DOXACURIUM CHEMBL1237123 TdgClinicalTrial, TEND
CHRM2 1129 FLAVOXATE CHEMBL1493 TdgClinicalTrial, TEND
CHRM2 1129 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
CHRM2 1129 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, TEND, DrugBank 10227113, 17848919
CHRM2 1129 TERFENADINE CHEMBL17157 binder DrugBank 10212017
CHRM2 1129 OXYPHENCYCLIMINE CHEMBL1495 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 3247303, 1426023
CHRM2 1129 PROCYCLIDINE CHEMBL86715 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 20624420, 2253700, 1426023, 2027917
CHRM2 1129 PROMAZINE CHEMBL564 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 DARIFENACIN CHEMBL1346 antagonist GuideToPharmacologyInteractions, DrugBank 10374898, 18046909
CHRM2 1129 TRIDIHEXETHYL CHEMBL1201354 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 PILOCARPINE CHEMBL550 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 11752352, 18824613, 19465517
CHRM2 1129 DOXACURIUM CHLORIDE CHEMBL1237099 antagonist TdgClinicalTrial, TEND, DrugBank 9523819, 17139284, 17016423
CHRM2 1129 ACETYLCHOLINE CHEMBL667 agonist GuideToPharmacologyInteractions
CHRM2 1129 ERIBAXABAN CHEMBL476186 agonist GuideToPharmacologyInteractions
CHRM2 1129 XANOMELINE CHEMBL21536 agonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL343357 CHEMBL343357 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL139677 CHEMBL139677 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL266295 CHEMBL266295 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 STAUROSPORINE CHEMBL388978 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL279453 CHEMBL279453 antagonist GuideToPharmacologyInteractions
CHRM2 1129 ATROPINE CHEMBL517712 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
CHRM2 1129 BIPERIDEN (CHEMBL1101) CHEMBL1101 antagonist GuideToPharmacologyInteractions
CHRM2 1129 DICYCLOMINE CHEMBL1123 antagonist GuideToPharmacologyInteractions
CHRM2 1129 OXYBUTYNIN CHEMBL1231 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
CHRM2 1129 PIRENZEPINE CHEMBL9967 antagonist GuideToPharmacologyInteractions
CHRM2 1129 PROPANTHELINE CHEMBL1180725 antagonist GuideToPharmacologyInteractions
CHRM2 1129 ASM-024 CHEMBL3707249 antagonist ChemblInteractions
CHRM2 1129 ATROPINE SULFATE CHEMBL2146146 antagonist ChemblInteractions
CHRM2 1129 TOLTERODINE TARTRATE CHEMBL1722209 antagonist ChemblInteractions
CHRM2 1129 METHIXENE CHEMBL1201342 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 ETHOPROPAZINE CHEMBL1206 antagonist DrugBank 2236897, 2904117
CHRM2 1129 SCOPOLAMINE CHEMBL1187846 antagonist GuideToPharmacologyInteractions, DrugBank, TTD 11752352, 15627430
CHRM2 1129 BENZQUINAMIDE CHEMBL1201250 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM2 1129 TROPICAMIDE CHEMBL1200604 antagonist DrugBank 17594079
CHRM2 1129 GLYCOPYRROLATE CHEMBL1201335 antagonist, binder GuideToPharmacologyInteractions, DrugBank 10385241
CHRM2 1129 TOLTERODINE CHEMBL1382 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 14769832, 16188951, 11193006, 19168050
CHRM2 1129 DIMETHINDENE CHEMBL22108 antagonist DrugBank 8608784
CHRM2 1129 FURTRETHONIUM CHEMBL2110739 agonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL130715 CHEMBL130715 agonist GuideToPharmacologyInteractions
CHRM2 1129 ALCURONIUM CHEMBL1180293 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL2206331 CHEMBL2206331 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 STRYCHNINE CHEMBL227934 allosteric modulator GuideToPharmacologyInteractions
CHRM2 1129 BENZTROPINE MESYLATE CHEMBL1200383 antagonist GuideToPharmacologyInteractions
CHRM2 1129 DOTHIEPIN (CHEMBL1492500) CHEMBL1492500 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL580785 CHEMBL580785 antagonist GuideToPharmacologyInteractions
CHRM2 1129 HEXOCYCLIUM CHEMBL1201325 antagonist GuideToPharmacologyInteractions
CHRM2 1129 HIMBACINE CHEMBL277642 antagonist GuideToPharmacologyInteractions
CHRM2 1129 IMIPRAMINE CHEMBL11 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL1256682 CHEMBL1256682 antagonist GuideToPharmacologyInteractions
CHRM2 1129 HYDROCHLORIC ACID CHEMBL1231821 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL73341 CHEMBL73341 antagonist GuideToPharmacologyInteractions
CHRM2 1129 SOLIFENACIN CHEMBL1734 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
CHRM2 1129 CLIDINIUM CHEMBL620 antagonist GuideToPharmacologyInteractions
CHRM2 1129 QUINUCLIDINYL BENZILATE CHEMBL12980 antagonist GuideToPharmacologyInteractions
CHRM2 1129 CHEMBL1671887 CHEMBL1671887 antagonist GuideToPharmacologyInteractions
CHRM2 1129 TRIPITRAMINE CHEMBL265256 antagonist GuideToPharmacologyInteractions
CHRM2 1129 TROSPIUM CHLORIDE CHEMBL3084748 antagonist ChemblInteractions
CHRM2 1129 OXYBUTYNIN CHLORIDE CHEMBL1133 antagonist ChemblInteractions
CHRM2 1129 DOXEPIN CHEMBL1628227 TdgClinicalTrial
CHRM2 1129 METOCURINE CHEMBL1259 antagonist DrugBank 7437219
CHRM2 1129 COCAINE CHEMBL370805 antagonist DrugBank 3047364, 15351386

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRM2 rs6962027 A fluticasone/salmeterol efficacy yes The "major" allele is associated with increased response. It is not clear whether that is A or T on the positive chromosomal strand. Allele A is associated with response to fluticasone/salmeterol in people with Asthma as compared to allele T. 22370858 1183703247
CHRM2 rs6962027 A fluticasone/salmeterol efficacy yes The "major" allele is associated with increased response. It is not clear whether that is A or T on the positive chromosomal strand. Allele A is associated with response to fluticasone/salmeterol in people with Asthma as compared to allele T. 22370858 1183703276
CHRM2 rs8191992 A fluticasone/salmeterol efficacy yes The "major" allele is associated with increased response. It is not clear whether that is A or T on the positive chromosomal strand. Allele A is associated with response to fluticasone/salmeterol in people with Asthma as compared to allele T. 22370858 1183702665