Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GLCCI1 rs12537880 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257668
GLCCI1 rs7800750 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257677
GLCCI1 rs17142716 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257902
GLCCI1 rs10952084 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257931
GLCCI1 rs6964558 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257940
GLCCI1 rs6463755 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257848
GLCCI1 rs4236406 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257884
GLCCI1 rs10253260 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257922
GLCCI1 rs37973 G glucocorticoids efficacy yes as part of a two SNP predictive test of FEV1 change, which identified patients with good or poor steroid response (highest or lowest quartile, respectively). P values are for predictive performance of the test. Allele G is associated with increased response to glucocorticoids in people with Asthma as compared to allele A. 22641026 827921716
GLCCI1 rs37973 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257622
GLCCI1 rs10257285 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257975
GLCCI1 rs38010 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257695
GLCCI1 rs10243846 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257749
GLCCI1 rs4725061 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257785
GLCCI1 rs13222222 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257803
GLCCI1 rs6969971 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257812
GLCCI1 rs9648623 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257821
GLCCI1 rs37972 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257599
GLCCI1 rs2041362 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257704
GLCCI1 rs715377 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257657
GLCCI1 rs37976 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257635
GLCCI1 rs11976862 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257875
GLCCI1 rs13242904 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257830
GLCCI1 rs7801924 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257776
GLCCI1 rs11978165 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257839
GLCCI1 rs1476823 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257722
GLCCI1 rs16872488 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257857
GLCCI1 rs17142727 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257913
GLCCI1 rs6956039 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257954
GLCCI1 rs2191318 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257866
GLCCI1 rs10226865 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257794
GLCCI1 rs4725068 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448258007
GLCCI1 rs12668352 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257987
GLCCI1 rs929509 C corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele C is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257998
GLCCI1 rs1468594 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257965
GLCCI1 rs37990 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257686
GLCCI1 rs7792118 G corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele G is not associated with response to corticosteroids in people with Asthma as compared to allele A. 27523435 1448257646
GLCCI1 rs17141876 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257713
GLCCI1 rs10229643 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele T. 27523435 1448257731
GLCCI1 rs13239966 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257740
GLCCI1 rs10435183 A corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele G. 27523435 1448257767
GLCCI1 rs13245462 T corticosteroids efficacy no The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837. Allele T is not associated with response to corticosteroids in people with Asthma as compared to allele C. 27523435 1448257758