Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRNA4 1137 MEPHOBARBITAL CHEMBL45029 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 CHEMBL407217 CHEMBL407217 channel blocker GuideToPharmacologyInteractions
CHRNA4 1137 AZD1446 CHEMBL2179529 agonist ChemblInteractions, TTD
CHRNA4 1137 BENZTROPINE MESYLATE CHEMBL1200383 antagonist TTD
CHRNA4 1137 PENTOLINIUM CHEMBL1271 antagonist TTD
CHRNA4 1137 CHEMBL1201135 CHEMBL1201135 agonist TTD
CHRNA4 1137 MECAMYLAMINE (CHEMBL267936) CHEMBL267936 antagonist TTD
CHRNA4 1137 DIANICLINE CHEMBL187927 agonist TTD
CHRNA4 1137 TALBUTAL CHEMBL1200802 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 BUTALBITAL CHEMBL454 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 PRIMIDONE CHEMBL856 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 BUTETHAL CHEMBL404422 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 CHEMBL1876219 CHEMBL1876219 agonist GuideToPharmacologyInteractions
CHRNA4 1137 HEXAMETHONIUM CHEMBL100622 channel blocker GuideToPharmacologyInteractions
CHRNA4 1137 ISPRONICLINE CHEMBL188462 partial agonist, agonist TdgClinicalTrial, ChemblInteractions, TTD
CHRNA4 1137 CP-601927 CHEMBL3707250 partial agonist ChemblInteractions
CHRNA4 1137 DEXMECAMYLAMINE CHEMBL2103881 antagonist ChemblInteractions
CHRNA4 1137 BRADANICLINE CHEMBL1258006 agonist TTD
CHRNA4 1137 DEXEFAROXAN CHEMBL1357517 agonist TTD
CHRNA4 1137 OLEIC ACID CHEMBL8659 antagonist TTD
CHRNA4 1137 TEBANICLINE TOSYLATE CHEMBL430497 agonist ChemblInteractions
CHRNA4 1137 NICOTINE POLACRILEX CHEMBL1201536 agonist ChemblInteractions
CHRNA4 1137 SECOBARBITAL CHEMBL447 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 PHENOBARBITAL CHEMBL40 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 APROBARBITAL CHEMBL7863 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 HEXOBARBITAL CHEMBL7728 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 EPIBATIDINE CHEMBL6623 agonist GuideToPharmacologyInteractions
CHRNA4 1137 CHEMBL3103988 CHEMBL3103988 allosteric modulator GuideToPharmacologyInteractions
CHRNA4 1137 ABT-560 CHEMBL3707354 modulator ChemblInteractions
CHRNA4 1137 NICOTINE CHEMBL3 agonist, antagonist TdgClinicalTrial, ChemblInteractions, TEND, TTD
CHRNA4 1137 AZD0328 CHEMBL2151437 agonist TTD
CHRNA4 1137 PENTOBARBITAL CHEMBL448 TdgClinicalTrial, TEND
CHRNA4 1137 ALTINICLINE CHEMBL111659 agonist ChemblInteractions
CHRNA4 1137 BUTABARBITAL CHEMBL449 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 METHARBITAL CHEMBL450 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 THIOPENTAL CHEMBL441 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 VARENICLINE CHEMBL1396 partial agonist, agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 17692720, 11752352, 18288085, 17626178, 17573127
CHRNA4 1137 AMOBARBITAL CHEMBL267894 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 HEPTABARBITAL CHEMBL468837 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 BARBITAL CHEMBL444 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA4 1137 POZANICLINE CHEMBL127071 partial agonist TdgClinicalTrial, ChemblInteractions, DrugBank
CHRNA4 1137 CYTISINE CHEMBL497939 agonist DrugBank 11553677, 25517706
CHRNA4 1137 RIVANICLINE CHEMBL132966 agonist TdgClinicalTrial, GuideToPharmacologyInteractions
CHRNA4 1137 ATRACURIUM CHEMBL1360 antagonist GuideToPharmacologyInteractions, TTD
CHRNA4 1137 CHEMBL490153 CHEMBL490153 channel blocker GuideToPharmacologyInteractions
CHRNA4 1137 TC-2216 CHEMBL504652 antagonist ChemblInteractions
CHRNA4 1137 SOFINICLINE CHEMBL238465 agonist ChemblInteractions, TTD
CHRNA4 1137 TC-6499 CHEMBL3545353 agonist TdgClinicalTrial, ChemblInteractions
CHRNA4 1137 VARENICLINE TARTRATE CHEMBL2062259 agonist ChemblInteractions
CHRNA4 1137 TRIMETHAPHAN CHEMBL1201329 antagonist TTD

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRNA4 rs1044396 A methylphenidate efficacy no This was based on parental retrospective yes/no reports on response. Allele A is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele G. 17948872 982015252
CHRNA4 rs2229959 C nicotine other yes Response(sweating, heart pounding and nausea) to the first experimental cigarette was measured using the NEQ(nicotine effects scale). Allele C is associated with increased response to nicotine in people with daily smoking as compared to allele A. 20854418 981483844
CHRNA4 rs6090384 C methylphenidate efficacy no This was based on parental retrospective yes/no reports on response. Allele C is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele T. 17948872 982015260
CHRNA4 rs1044396 GG varenicline efficacy yes CC genotype had lower success rate when in treatment with varenicline (29.5%) compared with patients with CT or TT genotypes. Genotype GG is associated with decreased response to varenicline in people with Tobacco Use Disorder as compared to genotypes AA + AG. 25774163 1445402071
CHRNA4 rs2236196 AA + AG varenicline efficacy no Genotypes AA + AG is not associated with response to varenicline in people with Tobacco Use Disorder as compared to genotype GG. 25774163 1445402137
CHRNA4 rs2273502 T nicotine efficacy no Study looked at the effect of nicotine on performance in attention-related tasks. Allele T is not associated with response to nicotine in women as compared to allele C. 20231857 1450812661
CHRNA4 rs3827020 C nicotine other no No significant association between this allele and status as a smoker or non-smoker. Allele C is not associated with exposure to nicotine in men as compared to allele T. 29666375 1450930694
CHRNA4 rs2236196 G bupropion efficacy no Authors looked at the effect of variants on response to the smoking cessation therapies varenicline, bupropion and nicotine replacement therapy. It is assumed that the authors tested the association between the G allele and nicotine dependence as compared to both the A and del alleles. Please note that alleles have been complemented to the positive strand. Allele G is not associated with response to bupropion, nicotine and varenicline in people with Tobacco Use Disorder as compared to allele A. 29196725 1449156016