PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SUMO1	0	DTX2	3	two hybrid	Rolland T (2014)	1
SFN	1	DTX2	3	affinity chromatography technology	Benzinger A (2005)	1
TRIM25	5	SEC23B	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D4	0	DTX2	3	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Markson G (2009), Rolland T (2014)	4
TRIM25	5	FAM168A	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIP13	0	RBPMS	0	two hybrid	Rual JF (2005)	1
FAM168A	0	DTX2	3	two hybrid	Rolland T (2014)	1
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
TRIP13	0	DTX2	3	two hybrid	Rual JF (2005)	1
ARNT2	5	RIMBP3	0	two hybrid	Corominas R (2014)	1
TRIM25	5	DTX2	3	affinity chromatography technology	Choudhury NR (2017)	1
FAM168A	0	C1orf94	1	two hybrid	Rolland T (2014)	1
UBQLN4	2	C1orf94	1	two hybrid	Lim J (2006)	1
UBE2D4	0	TRIM25	5	two hybrid	Markson G (2009)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
EIF4ENIF1	1	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDC1	8	DTX2	3	two hybrid	Woods NT (2012)	1
UBE2D1	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SPAG8	0	DTX2	3	two hybrid	Rolland T (2014)	1
FHL2	0	DTX2	3	two hybrid	Rolland T (2014)	1
MCM2	3	SFN	1	affinity chromatography technology	Drissi R (2015)	1
TRIP6	2	KRTAP26-1	0	two hybrid	Rolland T (2014)	1
SPG21	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RBPMS	0	FAM168A	0	two hybrid	Rolland T (2014)	1
MCM2	3	FHL2	0	affinity chromatography technology	Drissi R (2015)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
UBE2D3	1	DTX2	3	two hybrid	Rolland T (2014)	1
GOLGA2	2	GLYCTK	5	two hybrid	Rolland T (2014)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MCM2	3	SEC23B	0	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	DTX2	3	affinity chromatography technology	Drissi R (2015)	1
HPCAL1	0	DTX2	3	two hybrid	Rual JF (2005)	1
SPG21	0	TRIM54	1	two hybrid	Rolland T (2014)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
DTX2	3	ZNF641	0	two hybrid	Yu H (2011)	1
SFN	1	PLEKHF2	1	two hybrid	Rual JF (2005)	1
TRIM54	1	UBE2D3	1	pull down	Loch CM (2012)	1
GOLGA2	2	DTX2	3	two hybrid	Rolland T (2014)	1
SUMO1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
NCS1	2	DTX2	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
DTX2	3	DTX2	3	two hybrid	Rolland T (2014)	1
ARNT2	5	GOLGA2	2	two hybrid	Corominas R (2014)	1
UBQLN4	2	SPAG8	0	two hybrid	Lim J (2006)	1
ABHD16A	2	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
QARS	1	TRIP13	0	two hybrid	Rolland T (2014)	1
TRIM25	5	HPCAL1	0	affinity chromatography technology	Choudhury NR (2017)	1
ARNT2	5	TRIP6	2	two hybrid	Corominas R (2014)	1
HDC	1	DTX2	3	two hybrid	Rolland T (2014)	1
ARNT2	5	RFX6	3	two hybrid	Corominas R (2014)	1
RIMBP3	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM25	5	TRIP13	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MCM2	3	UBE2D3	1	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	FAM168A	0	affinity chromatography technology	Drissi R (2015)	1
UBQLN4	2	DTX2	3	two hybrid	Lim J (2006)	1
HPCAL4	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DTX2	3	KLC3	3	two hybrid	Rolland T (2014)	1
ARNT2	5	DTX2	3	two hybrid	Corominas R (2014)	1
C1orf94	1	DTX2	3	two hybrid	Rolland T (2014)	1
TRIP13	0	KRTAP26-1	0	two hybrid	Rolland T (2014)	1
PLEKHF2	1	DTX2	3	two hybrid	Rolland T (2014)	1
RHOXF2	0	DTX2	3	two hybrid	Rual JF (2005)	1
VSNL1	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MCM2	3	QARS	1	affinity chromatography technology	Drissi R (2015)	1
PLSCR1	0	DTX2	3	two hybrid	Rual JF (2005)	1
TRIP6	2	DTX2	3	two hybrid	Rolland T (2014)	1
STX12	2	DTX2	3	two hybrid	Rolland T (2014)	1
ALKBH4	2	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
QARS	1	KLC3	3	two hybrid	Rolland T (2014)	1
SEC22A	0	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MCM2	3	UBE2D4	0	affinity chromatography technology	Drissi R (2015)	1
DTX2	3	RFX6	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DTX2	3	KRTAP26-1	0	two hybrid	Rolland T (2014)	1
ARNT2	5	PLSCR1	0	two hybrid	Corominas R (2014)	1
QARS	1	DTX2	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DTX2	3	GLYCTK	5	two hybrid	Rolland T (2014)	1
TRIP13	0	GLYCTK	5	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MCM2	3	UBE2D1	0	affinity chromatography technology	Drissi R (2015)	1
SEC23B	0	DTX2	3	two hybrid	Rolland T (2014)	1
RBPMS	0	GLYCTK	5	two hybrid	Rolland T (2014)	1
RBPMS	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM54	1	DTX2	3	two hybrid	Rolland T (2014)	1
STX12	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCALD	1	DTX2	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
MDC1	8	TRIP13	0	affinity chromatography technology	Woods NT (2012)	1
RHOXF2	0	TRIP13	0	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2