Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRNB2 1141 TC-2216 CHEMBL504652 antagonist ChemblInteractions
CHRNB2 1141 VARENICLINE CHEMBL1396 PharmGKB, TdgClinicalTrial
CHRNB2 1141 CP-601927 CHEMBL3707250 partial agonist ChemblInteractions
CHRNB2 1141 RIVANICLINE CHEMBL132966 TdgClinicalTrial, DrugBank 12170059
CHRNB2 1141 ISPRONICLINE CHEMBL188462 partial agonist TdgClinicalTrial, ChemblInteractions
CHRNB2 1141 TC-6499 CHEMBL3545353 agonist TdgClinicalTrial, ChemblInteractions
CHRNB2 1141 ALTINICLINE CHEMBL111659 agonist ChemblInteractions
CHRNB2 1141 VARENICLINE TARTRATE CHEMBL2062259 agonist ChemblInteractions
CHRNB2 1141 TEBANICLINE TOSYLATE CHEMBL430497 agonist ChemblInteractions
CHRNB2 1141 ABT-560 CHEMBL3707354 modulator ChemblInteractions
CHRNB2 1141 NICOTINE POLACRILEX CHEMBL1201536 agonist ChemblInteractions
CHRNB2 1141 AZD1446 CHEMBL2179529 agonist ChemblInteractions
CHRNB2 1141 DEXMECAMYLAMINE CHEMBL2103881 antagonist ChemblInteractions
CHRNB2 1141 POZANICLINE CHEMBL127071 partial agonist TdgClinicalTrial, ChemblInteractions, DrugBank
CHRNB2 1141 SOFINICLINE CHEMBL238465 agonist ChemblInteractions, TTD
CHRNB2 1141 NICOTINE CHEMBL3 agonist TdgClinicalTrial, ChemblInteractions, TEND

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRNB2 rs2072661 AA + AG varenicline efficacy no Genotypes AA + AG are not associated with response to varenicline in people with Tobacco Use Disorder as compared to genotype GG. 25774163 1445402189
CHRNB2 rs2072658 AG nicotine other yes Response(sweating, heart pounding and nausea) to the first experimental cigarette was measured using the NEQ(nicotine effects scale). There were no AA subjects. Genotype AG is associated with increased response to nicotine in people with daily smoking as compared to genotype GG. 20854418 981483837
CHRNB2 rs2072660 CT + TT varenicline efficacy no Genotypes CT + TT are not associated with response to varenicline in people with Tobacco Use Disorder as compared to genotype CC. 25774163 1445402159
CHRNB2 rs12072348 C nicotine efficacy no Study looked at the effect of nicotine on performance in attention-related tasks. Allele C is not associated with response to nicotine in women as compared to allele A. 20231857 1450812696
CHRNB2 rs2072661 A bupropion efficacy no Authors looked at the effect of variants on response to the smoking cessation therapies varenicline, bupropion and nicotine replacement therapy. Please note that alleles have been complemented to the positive strand. Allele A is not associated with response to bupropion, nicotine and varenicline in people with Tobacco Use Disorder as compared to allele G. 29196725 1449155973
CHRNB2 rs4845652 T nicotine efficacy no Study looked at the effect of nicotine on performance in attention-related tasks. Allele T is not associated with response to nicotine in women as compared to allele C. 20231857 1450812691