PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NLRP3	2	STUB1	4	affinity chromatography technology	Yan Y (2015)	1
TRIM31	0	NLRP3	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Song H (2016), Song H (2016), Song H (2016), Song H (2016)	4
LUC7L	2	LUC7L3	2	affinity chromatography technology	Huttlin EL (2015)	1
NLRP3	2	RBBP7	1	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	LUC7L	2	affinity chromatography technology	Hein MY (2015)	1
DHX33	1	NLRP3	2	affinity chromatography technology	Weng L (2014)	1
NLRP3	2	MARCH7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yan Y (2015), Yan Y (2015), Yan Y (2015)	3
ARHGAP17	1	SH3BP1	0	affinity chromatography technology	Huttlin EL (2017)	1
NLRP3	2	PHRF1	7	affinity chromatography technology	Hein MY (2015)	1
SH3BP1	0	NLRP3	2	biochemical	Wan C (2015)	1
NLRP3	2	DNAJA2	2	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	SUGT1	1	affinity chromatography technology, affinity chromatography technology	Mayor A (2007), Mayor A (2007)	2
NLRP3	2	HNRNPC	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	FAF1	1	two hybrid, pull down, affinity chromatography technology	Kinoshita T (2006), Kinoshita T (2006), Kinoshita T (2006)	3
HDAC6	0	STUB1	4	affinity chromatography technology	Cook C (2012)	1
NLRP3	2	LTBP4	6	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	FBXO28	2	affinity chromatography technology	Taipale M (2012)	1
NLRP3	2	URB1	9	affinity chromatography technology	Hein MY (2015)	1
MEFV	3	ULK1	8	affinity chromatography technology, pull down	Kimura T (2015), Kimura T (2015)	2
NLRP3	2	NECTIN3	0	affinity chromatography technology	Hein MY (2015)	1
ARHGAP17	1	NLRP3	2	biochemical	Wan C (2015)	1
HSP90AA1	7	SUGT1	1	pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang M (2008), Lee YT (2004), Lee YT (2004), Mayor A (2007), Spiechowicz M (2007), Spiechowicz M (2007), Gano JJ (2010), Niikura Y (2006), Niikura Y (2006), Niikura Y (2006), Liu XS (2012), Goral A (2016), Goral A (2016)	13
NLRP3	2	GPATCH4	1	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	KIAA2013	0	affinity chromatography technology	Hein MY (2015)	1
CBX3	1	FAF1	1	biochemical	Wan C (2015)	1
CBX5	3	HIST1H1B	4	affinity chromatography technology, fluorescent resonance energy transfe	Hale TK (2006), Hale TK (2006)	2
NLRP3	2	TOP1	1	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	PCGF5	1	affinity chromatography technology	Hein MY (2015)	1
NLRC4	2	NLRP3	2	affinity chromatography technology	Damiano JS (2004)	1
CBX5	3	RBBP7	1	affinity chromatography technology	Nozawa RS (2010)	1
NLRP3	2	LUC7L3	2	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	SNRPB	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	COPS7A	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	HIST1H1B	4	affinity chromatography technology	Hein MY (2015)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
NLRP3	2	DMAP1	2	affinity chromatography technology	Hein MY (2015)	1
MEFV	3	NLRP3	2	affinity chromatography technology	Kimura T (2015)	1
NLRP3	2	UBR5	13	affinity chromatography technology	Yan Y (2015)	1
HSP90AA1	7	FBXL2	2	affinity chromatography technology	Taipale M (2012)	1
NLRP3	2	ARIH2	4	affinity chromatography technology	Kawashima A (2017)	1
NLRP3	2	ZC3H8	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	AP3B1	3	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	MTCH1	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	SPAST	8	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	FBXO28	2	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	DNAJA2	2	affinity chromatography technology, biochemical	Skarra DV (2011), Wan C (2015)	2
NLRP3	2	ULK1	8	affinity chromatography technology	Kimura T (2015)	1
NLRP3	2	UQCRQ	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	SMARCA5	4	affinity chromatography technology	Hein MY (2015)	1
USP50	4	HSP90AA1	7	two hybrid	Aressy B (2010)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
FBXL2	2	NLRP3	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Han S (2015), Han S (2015), Han S (2015)	3
USP50	4	LUC7L	2	affinity chromatography technology	Sowa ME (2009)	1
NLRP3	2	YBX3	0	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	MCFD2	1	biochemical	Wan C (2015)	1
NLRP3	2	HDAC6	0	affinity chromatography technology	Hwang I (2015)	1
NLRP3	2	FEM1A	2	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	CBX5	3	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	GEMIN2	1	affinity chromatography technology	Hein MY (2015)	1
TOP1	1	HNRNPC	0	affinity chromatography technology, biochemical	Czubaty A (2005), Havugimana PC (2012)	2
NLRP3	2	CCDC86	1	affinity chromatography technology	Hein MY (2015)	1
USP50	4	NLRP3	2	affinity chromatography technology	Lee JY (2017)	1
NLRP3	2	HSP90AA1	7	affinity chromatography technology	Mayor A (2007)	1
HDAC6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kekatpure VD (2009), Rao R (2008), Bali P (2005), Kovacs JJ (2005), New M (2013), Rao R (2012), Kovacs JJ (2005)	7
NLRP3	2	FBXL6	5	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	NLRP5	11	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	PHF14	6	affinity chromatography technology	Hein MY (2015)	1
NLRP3	2	CBX3	1	affinity chromatography technology	Hein MY (2015)	1
RBBP7	1	SMARCA5	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2