PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GPRASP2	0	PNPLA6	2	affinity chromatography technology	Li S (2014)	1
ADRB1	3	GPRASP1	5	pull down	Simonin F (2004)	1
PTN	0	GPRASP2	0	two hybrid	Goehler H (2004)	1
BARD1	4	LRIF1	3	two hybrid	Goehler H (2004)	1
CDC73	1	HAP1	1	two hybrid	Vinayagam A (2011)	1
DISC1	6	GPRASP2	0	two hybrid	Camargo LM (2007)	1
AGO1	11	AGO2	10	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang V (2013), Huang V (2013), Huang V (2013), Li S (2014), Li S (2014)	5
CTSG	0	TCF25	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RIPK4	0	IRS4	2	affinity chromatography technology	Rodriguez J (2016)	1
RIPK4	0	MLF2	1	affinity chromatography technology	Rodriguez J (2016)	1
GPRASP2	0	FYTTD1	2	affinity chromatography technology	Li S (2014)	1
FRAT1	0	GPRASP2	0	two hybrid	Wang J (2011)	1
LRIF1	3	HAP1	1	two hybrid, two hybrid	Goehler H (2004), Goehler H (2004)	2
RIPK4	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
HTR7	2	GPRASP1	5	pull down	Simonin F (2004)	1
STMN2	0	GPRASP1	5	two hybrid	Stelzl U (2005)	1
GPRASP2	0	EIF3E	1	affinity chromatography technology	Li S (2014)	1
EGLN3	0	ASPM	9	affinity chromatography technology	Rodriguez J (2016)	1
CBX8	3	GPRASP2	0	two hybrid	Rolland T (2014)	1
CUL3	17	RPS2	3	affinity chromatography technology	Bennett EJ (2010)	1
KLHL2	0	TCF25	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	KEAP1	0	affinity chromatography technology	Rodriguez J (2016)	1
HAP1	1	GPRASP2	0	two hybrid	Goehler H (2004)	1
GPRASP2	0	CFAP206	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TXN2	0	TXN	1	biochemical	Wan C (2015)	1
STMN2	0	GPRASP2	0	two hybrid	Vinayagam A (2011)	1
CCDC8	1	RPL28	0	affinity chromatography technology	Hanson D (2014)	1
EGLN3	0	GPRASP2	0	affinity chromatography technology	Rodriguez J (2016)	1
BARD1	4	HAP1	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
ADRB1	3	GPRASP2	0	pull down	Simonin F (2004)	1
RPL28	0	GPRASP2	0	affinity chromatography technology	Huttlin EL (2017)	1
GPRASP2	0	CHCHD3	0	affinity chromatography technology	Li S (2014)	1
CUL3	17	IRS4	2	affinity chromatography technology	Bennett EJ (2010)	1
GPRASP2	0	MYOT	0	two hybrid	Wang J (2011)	1
GPRASP2	0	KEAP1	0	affinity chromatography technology	Li S (2014)	1
CCDC8	1	RPS2	3	affinity chromatography technology	Hanson D (2014)	1
CALCR	0	GPRASP2	0	pull down	Simonin F (2004)	1
CUL3	17	WDR18	2	affinity chromatography technology	Bennett EJ (2010)	1
AGO2	10	GPRASP2	0	affinity chromatography technology, affinity chromatography technology	Li S (2014), Li S (2014)	2
GPRASP2	0	TXN2	0	two hybrid	Wang J (2011)	1
HTR7	2	CUL3	17	affinity chromatography technology	Matthys A (2012)	1
CUL3	17	GPRASP2	0	affinity chromatography technology	Bennett EJ (2010)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
GPRASP2	0	DIMT1	0	affinity chromatography technology	Li S (2014)	1
RIPK4	0	TCF25	0	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	KEAP1	0	affinity chromatography technology, bioid	Sowa ME (2009), Coyaud E (2015)	2
GPRASP2	0	MLF2	1	affinity chromatography technology	Li S (2014)	1
ARHGEF6	0	GPRASP2	0	two hybrid	Vinayagam A (2011)	1
GPRASP2	0	NDUFS7	1	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	ASPM	9	affinity chromatography technology	Li S (2014)	1
NEPRO	0	RPL28	0	affinity chromatography technology	Blomen VA (2015)	1
EGLN3	0	NDUFS7	1	affinity chromatography technology	Rodriguez J (2016)	1
IRS4	2	GPRASP2	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
GPRASP2	0	MAP7	3	affinity chromatography technology	Li S (2014)	1
RPL28	0	RPS2	3	biochemical	Kristensen AR (2012)	1
EGLN3	0	MLF2	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
PRG2	2	GPRASP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS2	3	EIF3E	1	biochemical	Kristensen AR (2012)	1
KLHL2	0	GPRASP2	0	affinity chromatography technology	Huttlin EL (2017)	1
GPRASP2	0	TRIM32	2	affinity chromatography technology	Li S (2014)	1
AGO1	11	GPRASP2	0	affinity chromatography technology, affinity chromatography technology	Li S (2014), Li S (2014)	2
EGLN3	0	PNPLA6	2	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	ASPM	9	affinity chromatography technology	Bennett EJ (2010)	1
GPRASP2	0	WDR18	2	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	NEPRO	0	affinity chromatography technology	Li S (2014)	1
HTT	14	GPRASP2	0	two hybrid	Goehler H (2004)	1
GPRASP2	0	TCF25	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Li S (2014), Li S (2014), Rolland T (2014), Huttlin EL (2017)	4
AGO2	10	BTRC	1	unspecified method	Elcheva I (2009)	1
CCDC8	1	MLF2	1	affinity chromatography technology	Hanson D (2014)	1
EIF3E	1	HAP1	1	two hybrid	Stelzl U (2005)	1
GPRASP2	0	RPS6KA5	2	two hybrid	Wang J (2011)	1
GPRASP2	0	CCDC59	1	affinity chromatography technology	Li S (2014)	1
EGLN3	0	CHCHD3	0	affinity chromatography technology	Rodriguez J (2016)	1
RPS2	3	TCF25	0	affinity chromatography technology	Huttlin EL (2015)	1
IRS4	2	RAF1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
GPRASP2	0	AP1G1	8	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	TMEM43	1	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	CDC73	1	affinity chromatography technology	Li S (2014)	1
CALCR	0	GPRASP1	5	pull down	Simonin F (2004)	1
HAP1	1	HTT	14	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Li XJ (1995), Li SH (1998), Li SH (1998), Li SH (1998), Li XJ (1995), Li XJ (1995), Li SH (1998), Goehler H (2004), Goehler H (2004)	9
RPS2	3	GPRASP2	0	affinity chromatography technology	Huttlin EL (2015)	1
BTRC	1	ALMS1	13	bioid	Coyaud E (2015)	1
CCDC8	1	MYO9B	11	affinity chromatography technology	Hanson D (2014)	1
KLHL2	0	KEAP1	0	affinity chromatography technology, affinity chromatography technology	Mai A (2004), Huttlin EL (2017)	2
BARD1	4	GPRASP2	0	two hybrid	Goehler H (2004)	1
BARD1	4	PTN	0	two hybrid	Goehler H (2004)	1
CBX8	3	HAP1	1	two hybrid	Stelzl U (2005)	1
GPRASP2	0	COPE	2	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	CCDC8	1	affinity chromatography technology	Li S (2014)	1
GPRASP2	0	RAF1	3	affinity chromatography technology	Li S (2014)	1
CTSG	0	GPRASP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IQCN	0	GPRASP2	0	affinity chromatography technology	Huttlin EL (2017)	1
GPRASP2	0	ALMS1	13	affinity chromatography technology	Li S (2014)	1
CUL3	17	AGO1	11	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	CCDC8	1	affinity chromatography technology	Rodriguez J (2016)	1
TSPOAP1	9	GPRASP2	0	two hybrid	Corominas R (2014)	1
KLHL2	0	CCDC8	1	affinity chromatography technology	Huttlin EL (2017)	1
IQCN	0	TCF25	0	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	TCF25	0	affinity chromatography technology	Rodriguez J (2016)	1
GPRASP2	0	GPRASP1	5	affinity chromatography technology	Li S (2014)	1
EGLN3	0	IRS4	2	affinity chromatography technology	Rodriguez J (2016)	1
AP1G1	8	AP1M1	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Foelsch H (1999), Page LJ (1995), Havugimana PC (2012), Hirst J (2000), Wan C (2015)	5
BTRC	1	GPRASP2	0	affinity chromatography technology	Sowa ME (2009)	1
GPRASP2	0	AP1M1	3	affinity chromatography technology	Li S (2014)	1
CBX8	3	DIMT1	0	affinity chromatography technology	Vandamme J (2011)	1
GPRASP2	0	LRIF1	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
RIPK4	0	GPRASP2	0	affinity chromatography technology	Rodriguez J (2016)	1
CHRM1	3	GPRASP2	0	pull down	Simonin F (2004)	1
BTRC	1	RIPK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Rodriguez J (2016)	3
HTR7	2	GPRASP2	0	pull down	Simonin F (2004)	1
GPRASP2	0	NOL4L-DT	0	two hybrid	Rolland T (2014)	1
CHRM1	3	GPRASP1	5	pull down	Simonin F (2004)	1
HTT	14	AGO2	10	affinity chromatography technology, affinity chromatography technology, imaging technique	Savas JN (2008), Savas JN (2008), Savas JN (2008)	3
RAF1	3	KEAP1	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CUL3	17	KLHL2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Takahashi D (2013), Rolland T (2014), Huttlin EL (2017)	4
EGLN3	0	TXN	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	TRIM32	2	affinity chromatography technology	Wimuttisuk W (2014)	1
GPRASP2	0	MYO9B	11	affinity chromatography technology	Li S (2014)	1
AGO1	11	TCF25	0	affinity chromatography technology	Li S (2014)	1
CCDC8	1	CHCHD3	0	affinity chromatography technology	Hanson D (2014)	1
GPRASP2	0	TXN	1	two hybrid	Wang J (2011)	1
CCDC8	1	IRS4	2	affinity chromatography technology	Hanson D (2014)	1
TSPOAP1	9	DISC1	6	two hybrid	Corominas R (2014)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
CCDC8	1	LMNB2	2	affinity chromatography technology	Hanson D (2014)	1
GPRASP2	0	LMNB2	2	affinity chromatography technology	Li S (2014)	1