PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF41	2	UBE2D3	1	pull down, pull down	Yu F (2008), Qiu XB (2004)	2
LTBR	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF166	0	NF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
NF2	1	7515	0	affinity chromatography technology	Zhou L (2015)	1
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
HERC2	9	UBE2D1	0	pull down	Bai B (2016)	1
MAVS	1	RNF114	0	affinity chromatography technology, imaging technique, biochemical	Lin B (2017), Lin B (2017), Lin B (2017)	3
RNF166	0	KIF1A	19	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAGEE2	0	RNF166	0	two hybrid, affinity chromatography technology	Kozakova L (2015), Kozakova L (2015)	2
PARP11	0	RNF114	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MAGEA1	0	RNF166	0	two hybrid, affinity chromatography technology	Kozakova L (2015), Kozakova L (2015)	2
CACNG5	0	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF166	0	CHD1L	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF13B	0	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Xia XZ (2000), Xia XZ (2000), He B (2010)	3
AMOT	6	NF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Li Y (2015), Li Y (2015), Hauri S (2013), Zhou L (2015)	5
USP2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
RNF166	0	TNKS2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF166	0	NEURL4	3	affinity chromatography technology	Huttlin EL (2015)	1
UBE2U	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2U	0	RNF114	0	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	RNF166	0	two hybrid	Markson G (2009)	1
NF2	1	TFCP2	1	affinity chromatography technology	Zhou L (2015)	1
PLPPR1	3	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF13B	0	TRAF3	1	affinity chromatography technology	Xu LG (2002)	1
UBE2D3	1	RNF166	0	two hybrid	Markson G (2009)	1
RNF166	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
RNF166	0	NUP58	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUP54	1	NUP98	5	biochemical	Wan C (2015)	1
RNF166	0	MAVS	1	affinity chromatography technology	Chen HW (2015)	1
UBE2D2	0	RNF166	0	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF114	0	two hybrid	Markson G (2009)	1
RNF166	0	LIG1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
SSSCA1	0	UBE2D1	0	biochemical	Havugimana PC (2012)	1
UBE2E1	1	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
RNF166	0	RNF41	2	two hybrid	Woodsmith J (2012)	1
NUP35	0	NUP54	1	bioid	Kim DI (2014)	1
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
LTBR	0	TRAF3	1	affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	VanArsdale TL (1997), Wu MY (1999), Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Mosialos G (1995), Li C (2003), Li C (2003), Force WR (1997), Force WR (1997), Huttlin EL (2015), Huttlin EL (2017)	12
USP2	0	TRIM9	3	two hybrid	Hayes SD (2012)	1
RNF166	0	HECTD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP12	1	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF13B	0	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
RNF166	0	AMOT	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF166	0	NUP54	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RNF166	0	MPDZ	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2Z	0	RNF166	0	two hybrid	Markson G (2009)	1
RNF166	0	NUP35	0	affinity chromatography technology	Huttlin EL (2015)	1
SSSCA1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
C11orf24	3	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E1	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
UBE2E2	1	MKRN3	2	two hybrid	Markson G (2009)	1
AMOT	6	AMOTL1	3	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013)	4
RNF166	0	AMOTL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFAIP3	3	RNF114	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Rodriguez MS (2014), Huttlin EL (2017)	5
RNF166	0	HERC2	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2Z	0	HLTF	7	two hybrid	van Wijk SJ (2009)	1
UBE2H	3	MKRN3	2	two hybrid	Markson G (2009)	1
CHD1L	5	TNKS2	6	affinity chromatography technology	Huttlin EL (2017)	1
TNKS	12	GMDS	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bisht KK (2012), Bisht KK (2012), Huttlin EL (2017)	3
CHD1L	5	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Brockschmidt A (2011), Kulkarni A (2013), Huttlin EL (2017)	5
CHD1L	5	HLTF	7	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
PARP11	0	RNF166	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E2	1	RNF114	0	two hybrid	Markson G (2009)	1
NUP35	0	NUP98	5	bioid	Kim DI (2014)	1
NUP35	0	NUP58	0	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
MAGEC2	0	RNF166	0	two hybrid	Kozakova L (2015)	1
PARP12	1	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
UBE2U	0	VPS11	3	two hybrid	Markson G (2009)	1
SSSCA1	0	TNKS2	6	affinity chromatography technology	Huttlin EL (2017)	1
USP2	0	RNF166	0	two hybrid	Hayes SD (2012)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
NF2	1	LIG3	6	affinity chromatography technology	Zhou L (2015)	1
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
CHD1L	5	7515	0	affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Huttlin EL (2017)	2
UBE2U	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
UBE2E2	1	RNF166	0	two hybrid	Markson G (2009)	1
NEURL4	3	SSSCA1	0	affinity chromatography technology	Al-Hakim AK (2012)	1
RNF166	0	NUP98	5	affinity chromatography technology	Huttlin EL (2015)	1
RNF166	0	TRIM9	3	two hybrid	Woodsmith J (2012)	1
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
HERC2	9	SSSCA1	0	affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Huttlin EL (2017)	2
UBE2W	0	RNF114	0	two hybrid	Markson G (2009)	1
UBE2E3	0	RNF166	0	two hybrid	Markson G (2009)	1
NUP35	0	MAVS	1	bioid	Kim DI (2014)	1
CHD1L	5	TNKS	12	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
LTBR	0	RNF166	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AMOT	6	MPDZ	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Sowa ME (2009), Wells CD (2006), Couzens AL (2013), Couzens AL (2013)	4
RNF166	0	CENPF	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAGEE2	0	TRAF6	0	two hybrid, affinity chromatography technology	Kozakova L (2015), Kozakova L (2015)	2
KIF1A	19	MKRN3	2	two hybrid	Corominas R (2014)	1
RNF166	0	ACY1	0	affinity chromatography technology	Huttlin EL (2015)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RNF166	0	PATJ	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
NF2	1	AMOTL1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Zhou L (2015), Huttlin EL (2017)	3
NUP58	0	NUP54	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	3
UBE2D4	0	MKRN3	2	two hybrid	Markson G (2009)	1
RNF166	0	TJP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2Z	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
GMDS	3	TNKS2	6	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
AMOT	6	PATJ	5	affinity chromatography technology, affinity chromatography technology, bioid	Wells CD (2006), Couzens AL (2013), Couzens AL (2013)	3
NUP58	0	NUP98	5	affinity chromatography technology	Hein MY (2015)	1
HERC2	9	UBE2D3	1	pull down	Wu W (2010)	1
HERC2	9	NEURL4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Galligan JT (2015)	5
TRAF6	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
RNF166	0	HLTF	7	affinity chromatography technology	Huttlin EL (2015)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
RNF166	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Chen HW (2015), Chen HW (2015)	2
TNFAIP3	3	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RNF166	0	two hybrid	Markson G (2009)	1
RNF166	0	LIG3	6	affinity chromatography technology	Huttlin EL (2017)	1
HERC2	9	MAVS	1	affinity chromatography technology	Galligan JT (2015)	1
UBE2W	0	MKRN3	2	two hybrid	Markson G (2009)	1
RNF166	0	TNKS	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
NF2	1	PARP1	3	affinity chromatography technology	Zhou L (2015)	1
UBE2E3	0	TRIM39	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2E2	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
NUP98	5	PARP11	0	affinity chromatography technology	Ewing RM (2007)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	MKRN3	2	two hybrid	Markson G (2009)	1
RNF166	0	7515	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	MKRN3	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
NF2	1	GMDS	3	affinity chromatography technology	Zhou L (2015)	1
RNF166	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Heath RJ (2016), Heath RJ (2016), Heath RJ (2016)	3
RNF166	0	SSSCA1	0	affinity chromatography technology	Huttlin EL (2015)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
UBE2D1	0	RNF166	0	two hybrid	Markson G (2009)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
RNF166	0	PARP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
UBE2E3	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2U	0	RNF166	0	two hybrid	van Wijk SJ (2009)	1
SSSCA1	0	TNKS	12	affinity chromatography technology	Huttlin EL (2017)	1
CLEC4E	1	RNF166	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	TRIM39	0	two hybrid	Markson G (2009)	1
UBE2H	3	RNF166	0	two hybrid	Markson G (2009)	1
RNF166	0	TFCP2	1	affinity chromatography technology	Huttlin EL (2015)	1
RNF166	0	VPS11	3	affinity chromatography technology	Huttlin EL (2015)	1
RNF166	0	GMDS	3	affinity chromatography technology	Huttlin EL (2015)	1
UBE2W	0	RNF166	0	two hybrid	Markson G (2009)	1