PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AGAP2	14	PIK3R1	6	pull down, affinity chromatography technology	Ye K (2000), Ye K (2000)	2
AGAP2	14	GRIP1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Chan CB (2011), Chan CB (2011), Chan CB (2011), Chan CB (2011), Chan CB (2011)	5
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
AGAP2	14	MPRIP	2	affinity chromatography technology	Pilot-Storck F (2010)	1
AGAP2	14	AKT1	1	pull down, fluorescent resonance energy transfe, affinity chromatography technology	Qi Q (2013), Qi Q (2013), Qi Q (2013)	3
HOMER1	1	AGAP2	14	affinity chromatography technology, pull down	Rong R (2003), Rong R (2003)	2
AGAP2	14	RAC1	7	two hybrid, pull down	Luo R (2012), Luo R (2012)	2
GRIP1	1	GRIA2	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hirbec H (2002), Hirbec H (2002), Correia SS (2008), Chan CB (2011), Chan CB (2011)	5
AGAP2	14	CDC42	3	two hybrid, pull down	Luo R (2012), Luo R (2012)	2
EPB41L1	4	AGAP2	14	two hybrid, pull down, affinity chromatography technology, pull down	Ye K (2000), Ye K (2000), Ye K (2000), Ye K (2000)	4
AGAP2	14	RHOA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Luo R (2012), Luo R (2012), Luo R (2012), Luo R (2012)	4
AKT1	1	NF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Tang X (2007), Tang X (2007), Tang X (2007), Tang X (2007), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Laulajainen M (2011), Ivanov AA (2017)	9
NF2	1	AGAP2	14	pull down	Tang X (2007)	1
RHOA	0	MPRIP	2	two hybrid, pull down	Gebbink MF (1997), Gebbink MF (1997)	2
AGAP2	14	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Chan CB (2011), Chan CB (2011)	2
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
AGAP2	14	RAC2	0	two hybrid	Luo R (2012)	1
AGAP2	14	ARF1	1	enzymatic study	Luo R (2012)	1