PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP162	3	CEP55	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP290	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
LCA5	1	CEP131	9	bioid	Gupta GD (2015)	1
KIAA0753	1	TRIM37	7	bioid	Firat-Karalar EN (2014)	1
AHI1	4	CEP131	9	bioid	Gupta GD (2015)	1
AHI1	4	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	TP53BP2	5	bioid	Gupta GD (2015)	1
OFD1	3	CCDC138	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
WRAP73	1	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	5
LCA5	1	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
TP53BP2	5	ZGPAT	3	two hybrid	Rolland T (2014)	1
CEP162	3	WRAP73	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
LCA5	1	CCDC138	2	bioid	Gupta GD (2015)	1
LCA5	1	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP131	9	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP162	3	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP55	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP290	5	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
KIAA0753	1	CEP55	2	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
ZRSR2	0	SSX2IP	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
CEP162	3	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP162	3	TP53BP2	5	bioid	Gupta GD (2015)	1
KIAA0753	1	KIF7	3	bioid	Gupta GD (2015)	1
CEP290	5	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
SSX2IP	0	OFD1	3	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
KIAA0753	1	CEP131	9	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP128	1	CEP55	2	bioid	Gupta GD (2015)	1
LCA5	1	WRAP73	1	bioid	Gupta GD (2015)	1
AHI1	4	CCDC138	2	bioid	Gupta GD (2015)	1
CEP128	1	CCDC138	2	bioid	Gupta GD (2015)	1
CEP128	1	CEP290	5	bioid	Gupta GD (2015)	1
SSX2IP	0	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	KIF7	3	bioid	Gupta GD (2015)	1
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	TRIM37	7	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP290	5	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCNH	3	SSX2IP	0	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
SSX2IP	0	AFDN	10	affinity chromatography technology, pull down, two hybrid	Asada M (2003), Asada M (2003), Asada M (2003)	3
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	CCDC138	2	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
KIAA0753	1	WRAP73	1	bioid	Gupta GD (2015)	1
CEP128	1	KIF7	3	bioid	Gupta GD (2015)	1
CEP135	2	CEP55	2	bioid	Gupta GD (2015)	1
AHI1	4	SSX2IP	0	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP290	5	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	CCDC138	2	bioid	Gupta GD (2015)	1
CEP128	1	CEP131	9	bioid	Gupta GD (2015)	1
CEP55	2	FBF1	2	two hybrid	Rolland T (2014)	1
CEP162	3	KIAA0753	1	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
ZGPAT	3	SSX2IP	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SSX2IP	0	ACTN1	5	affinity chromatography technology, pull down	Asada M (2003), Asada M (2003)	2
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	WRAP73	1	affinity chromatography technology	Hein MY (2015)	1
AHI1	4	WRAP73	1	bioid	Gupta GD (2015)	1
FBF1	2	PCM1	5	bioid	Gupta GD (2015)	1
AHI1	4	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	KIF7	3	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP131	9	affinity chromatography technology, pull down, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Gupta GD (2015), Gupta GD (2015)	4
CEP290	5	PCM1	5	bioid	Gupta GD (2015)	1
CEP135	2	TP53BP2	5	bioid	Gupta GD (2015)	1
SSX2IP	0	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIAA0753	1	OFD1	3	bioid, bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	4
CEP128	1	WRAP73	1	bioid	Gupta GD (2015)	1
SSX2IP	0	KIF7	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
FBF1	2	CEP131	9	bioid	Gupta GD (2015)	1
PCM1	5	WRAP73	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	TP53BP2	5	bioid	Gupta GD (2015)	1
CEP290	5	WRAP73	1	bioid	Gupta GD (2015)	1
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP290	5	KIF7	3	affinity chromatography technology	Gupta GD (2015)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
WRAP73	1	CEP135	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015), Huttlin EL (2017)	7
OFD1	3	CEP55	2	bioid	Gupta GD (2015)	1
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP290	5	KIAA0753	1	bioid	Gupta GD (2015)	1
LCA5	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	TP53BP2	5	bioid	Gupta GD (2015)	1
TP53BP2	5	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
LCA5	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
TRIM37	7	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CEP55	2	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
FBF1	2	TP53BP2	5	bioid	Gupta GD (2015)	1
FBF1	2	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP162	3	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
KIF7	3	CEP131	9	affinity chromatography technology	Hein MY (2015)	1