PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANKRD13B	1	RPLP1	0	two hybrid	Stelzl U (2005)	1
ANKRD13B	1	VCP	6	affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016)	2
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
VCP	6	PSMD4	1	affinity chromatography technology, affinity chromatography technology	Arrojo E Drigo R (2013), McNeill H (2004)	2
EGFR	5	HDAC1	4	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	PSMD4	1	protein complementation assay	Deribe YL (2009)	1
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
PSMD4	1	ANKRD13B	1	biochemical	Wan C (2015)	1
GNAI3	0	ANKRD13B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ANKRD13B	1	UBC	7	pull down, pull down	Tanno H (2012), Zhang X (2017)	2
HDAC1	4	ANKRD13B	1	affinity chromatography technology	Hein MY (2015)	1
BOD1L1	11	ANKRD13B	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
EGFR	5	ANKRD13B	1	affinity chromatography technology	Tanno H (2012)	1