PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAD51	3	RAD51D	1	imaging technique	Tarsounas M (2004)	1
A2M	8	SWSAP1	3	two hybrid	Soler-Lopez M (2011)	1
SWSAP1	3	RAD51D	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
RAD51C	1	RAD51B	1	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hussain S (2004), Sigurdsson S (2001), Miller KA (2002), Miller KA (2002), Miller KA (2002), Park JY (2014)	6
ZSWIM7	2	RAD51D	1	pull down	Liu T (2011)	1
PLA2G10	0	SWSAP1	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD51B	1	RAD51D	1	affinity chromatography technology	Miller KA (2002)	1
SWSAP1	3	XRCC3	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
RAD51C	1	XRCC3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Hussain S (2004), Miller KA (2002), Liu N (2002), Kurumizaka H (2001), Kurumizaka H (2001), Kurumizaka H (2001), Hein MY (2015), Park JY (2014)	8
SWSAP1	3	GAPDHS	1	affinity chromatography technology	Huttlin EL (2017)	1
ZSWIM7	2	SWSAP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Liu T (2011), Liu T (2011), Liu T (2011), Liu T (2011), Godin SK (2015), Huttlin EL (2017)	6
RAD51C	1	RAD51D	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Miller KA (2002), Liu N (2002), Yard BD (2016), Yard BD (2016), Park JY (2014)	5
ZSWIM7	2	XRCC3	1	pull down	Liu T (2011)	1
SWSAP1	3	RAD51	3	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
PLA2G10	0	ZSWIM7	2	affinity chromatography technology	Huttlin EL (2017)	1
RAD51	3	XRCC3	1	imaging technique	Tarsounas M (2004)	1
SWSAP1	3	RAD51C	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
SWSAP1	3	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
RAD51	3	RAD51C	1	imaging technique, affinity chromatography technology, imaging technique, affinity chromatography technology	Tarsounas M (2004), Rodrigue A (2006), Rodrigue A (2006), Park JY (2014)	4
SWSAP1	3	RAD51B	1	affinity chromatography technology, pull down	Liu T (2011), Liu T (2011)	2
RAD51	3	RAD51B	1	imaging technique	Tarsounas M (2004)	1