PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CNTFR	1	CLCF1	0	affinity chromatography technology, biochemical	Plun-Favreau H (2001), Plun-Favreau H (2001)	2
LIFR	1	CNTFR	1	pull down, affinity chromatography technology, pull down	Man D (2003), Man D (2003), He W (2002)	3
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
CNTFR	1	JPT2	0	two hybrid	Vinayagam A (2011)	1
LIFR	1	IL6ST	0	affinity chromatography technology, affinity chromatography technology	Timmermann A (2002), Mosley B (1996)	2
CNTFR	1	CNTF	3	pull down	Saggio I (1994)	1
CNTFR	1	APPBP2	3	two hybrid	Rual JF (2005)	1
CNTFR	1	PLSCR1	0	two hybrid	Rual JF (2005)	1
IL6ST	0	CNTFR	1	pull down, affinity chromatography technology	Man D (2003), Man D (2003)	2
CNTFR	1	KRTAP4-12	2	two hybrid	Rual JF (2005)	1