PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	COL1A2	1	affinity chromatography technology	Yao Z (2017)	1
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
ITGB1	4	THBS1	6	affinity chromatography technology	Ashton AW (2004)	1
ERAL1	0	COL1A2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RASGEF1B	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
COL1A2	1	PDGFA	1	pull down	Somasundaram R (1996)	1
CYLD	2	COL1A1	1	affinity chromatography technology	Elliott PR (2016)	1
ELAVL1	0	MFSD13A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ITGA2	1	ITGB1	4	affinity chromatography technology	Rantala JK (2011)	1
CAPN1	3	COL1A1	1	two hybrid	Jiang LQ (2002)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
MATN2	6	COL1A1	1	pull down	Piecha D (2002)	1
ATP13A2	1	COL1A1	1	two hybrid	Usenovic M (2012)	1
TXN	1	COL1A1	1	two hybrid, pull down	Matsumoto K (2002), Matsumoto K (2002)	2
THBS1	6	PDGFB	1	pull down	Hogg PJ (1997)	1
MMP2	2	ITGB1	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Kesanakurti D (2012), Kesanakurti D (2012), Kesanakurti D (2012)	3
ERAL1	0	COL1A1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMTC4	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2015)	1
P4HA2	3	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
PLOD1	2	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	RASGEF1B	1	affinity chromatography technology	Yao Z (2017)	1
COL1A1	1	ITGA2	1	biochemical	Staatz WD (1990)	1
EGFR	5	ITGB1	4	fluorescent resonance energy transfe	Petras M (2013)	1
COL1A1	1	ITGB1	4	biochemical	Staatz WD (1990)	1
COL1A1	1	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2
COL1A1	1	COL1A2	1	biochemical	Pace JM (2008)	1
BARD1	4	COL1A1	1	two hybrid	Woods NT (2012)	1
COL1A1	1	MMP2	2	pull down	Ellerbroek SM (2001)	1
COL1A1	1	SPARC	1	pull down	Sage H (1989)	1
ELAVL1	0	CAMKMT	1	affinity chromatography technology	Abdelmohsen K (2009)	1
C12orf57	2	COL1A1	1	biochemical	Havugimana PC (2012)	1
EGFR	5	COL1A1	1	affinity chromatography technology	Yao Z (2017)	1
TLE3	2	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
LIN9	3	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
COL1A1	1	PDGFA	1	pull down	Somasundaram R (1996)	1
TIMM44	1	COL1A2	1	affinity chromatography technology	Huttlin EL (2017)	1
COL7A1	19	COL1A1	1	pull down	Chen M (1997)	1
BRCA1	7	COL1A1	1	two hybrid	Woods NT (2012)	1
EGFR	5	TXN	1	protein complementation assay, affinity chromatography technology	Petschnigg J (2014), Petschnigg J (2014)	2
ELAVL1	0	ITGB1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
MAG	2	COL1A1	1	pull down	Fahrig T (1987)	1
YAF2	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
MCPH1	4	COL1A1	1	two hybrid	Liu X (2017)	1
UBC	7	COL1A1	1	pull down	Nathan JA (2013)	1
DNM3	3	COL1A1	1	affinity chromatography technology	Huttlin EL (2015)	1
COLGALT2	2	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	THBS1	6	affinity chromatography technology	Abdelmohsen K (2009)	1
TIMM44	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
SPARC	1	PDGFB	1	pull down	Raines EW (1992)	1
CD200R1	4	COL1A1	1	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
COL1A1	1	COL1A1	1	biochemical	Pace JM (2008)	1
THBS1	6	MMP2	2	two hybrid, affinity chromatography technology	Bein K (2000), Bein K (2000)	2
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
ELAVL1	0	COL1A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PKD1	18	COL1A1	1	pull down	Malhas AN (2002)	1
OTUB1	0	TXN	1	affinity chromatography technology	Scholz CC (2016)	1
PRELP	2	COL1A1	1	pull down	Bengtsson E (2002)	1
OTUB1	0	COL1A1	1	affinity chromatography technology	Scholz CC (2016)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
LPAR1	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2017)	1
IGFBP3	1	COL1A1	1	two hybrid, biochemical, affinity chromatography technology	Liu B (2003), Liu B (2003), Liu B (2003)	3
ELAVL1	0	TMTC4	1	affinity chromatography technology	Abdelmohsen K (2009)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
UBXN11	1	COLGALT2	2	affinity chromatography technology	Huttlin EL (2015)	1
THBS1	6	COL7A1	19	two hybrid	Aho S (1998)	1
COL1A1	1	RNH1	8	biochemical	Havugimana PC (2012)	1
UBXN11	1	COL1A1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COL1A1	1	NID1	6	pull down	Kohfeldt E (1998)	1
GIPC2	2	COL1A1	1	affinity chromatography technology	Huttlin EL (2015)	1
CAMKMT	1	COL1A1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MFSD13A	1	COL1A1	1	affinity chromatography technology	Huttlin EL (2015)	1
CAMKMT	1	COL1A2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
THBS1	6	COL1A1	1	pull down	Galvin NJ (1987)	1
YAF2	1	COL1A2	1	affinity chromatography technology	Huttlin EL (2017)	1
VWF	11	COL1A1	1	biochemical, pull down	Pareti FI (1986), Pareti FI (1986)	2
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
COL1A1	1	NID2	8	pull down	Kohfeldt E (1998)	1
CYLD	2	COL1A2	1	affinity chromatography technology	Elliott PR (2016)	1
COL1A2	1	PDGFB	1	pull down, far western blotting	Somasundaram R (1996), Somasundaram R (1996)	2