PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
TP53	0	CSNK2B	5	protein complementation assay	Srivastav RK (2011)	1
ADH5	1	ESRRA	2	two hybrid	Wang J (2011)	1
PHGDH	4	VTN	1	biochemical	Havugimana PC (2012)	1
ADH5	1	CSNK2B	5	two hybrid	Wang J (2011)	1
ADH5	1	ADH5	1	x-ray crystallography, two hybrid	Sanghani PC (2002), Wang J (2011)	2
CHD3	19	TP73	2	two hybrid	Minty A (2000)	1
ADH5	1	PRDX1	1	two hybrid	Wang J (2011)	1
PTGR1	1	ADH5	1	biochemical	Wan C (2015)	1
HDAC1	4	ESD	0	affinity chromatography technology	Joshi P (2013)	1
ADH5	1	ALDH4A1	5	biochemical	Wan C (2015)	1
ADH5	1	ESD	0	biochemical	Wan C (2015)	1
HDAC1	4	ADH5	1	affinity chromatography technology	Joshi P (2013)	1
ADH5	1	VTN	1	two hybrid	Wang J (2011)	1
VTN	1	APP	1	pull down	Olah J (2011)	1
STIP1	1	APP	1	pull down	Olah J (2011)	1
ALDH4A1	5	APP	1	pull down	Olah J (2011)	1
ADH5	1	ARNT	1	two hybrid	Wang J (2011)	1
HDAC1	4	TP73	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Uramoto H (2004), Uramoto H (2004), Uramoto H (2004), Zhang J (2007)	4
HDAC1	4	CSNK2B	5	affinity chromatography technology	Joshi P (2013)	1
TP53	0	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
ADH5	1	APP	1	pull down	Olah J (2011)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
TP53	0	ADH5	1	affinity chromatography technology	Lunardi A (2010)	1
ADH5	1	PQLC1	2	two hybrid	Wang J (2011)	1
HDAC1	4	CHD3	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong JK (1998), Tong JK (1998), Kuzmichev A (2002), Sun JM (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Havugimana PC (2012), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	12
PHGDH	4	STIP1	1	biochemical	Wan C (2015)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
PTPN4	0	ADH5	1	affinity chromatography technology	St-Denis N (2016)	1
TP63	0	ADH5	1	affinity chromatography technology	Lunardi A (2010)	1
PHGDH	4	APP	1	pull down	Olah J (2011)	1
SNTA1	1	ADH5	1	unspecified method	Boisguerin P (2004)	1
STIP1	1	ADH5	1	affinity chromatography technology	Zaman K (2016)	1
TP73	2	ADH5	1	affinity chromatography technology	Lunardi A (2010)	1
PHGDH	4	ADH5	1	biochemical	Wan C (2015)	1
ADH5	1	CHD3	19	two hybrid	Stelzl U (2005)	1
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
ALDH4A1	5	ESD	0	biochemical	Wan C (2015)	1