PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	RPL5	3	affinity chromatography technology	Drissi R (2015)	1
HIST3H2BB	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
HIST3H2BB	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
MCM2	3	HIST1H3B	3	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	HIST3H2BB	0	affinity chromatography technology	Drissi R (2015)	1
MCM5	1	HIST3H2BB	0	affinity chromatography technology	Drissi R (2015)	1
HUWE1	22	RPL5	3	affinity chromatography technology	Thompson JW (2014)	1
CDKN2A	1	MCM2	3	pull down	Ramachandran N (2004)	1
HDAC1	4	CDKN2A	1	pull down, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
CENPA	0	RNF2	1	biochemical	Obuse C (2004)	1
HIST1H3B	3	HIST3H2BB	0	affinity chromatography technology	Foltz DR (2006)	1
HIST3H2BB	0	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, pull down	Choi J (2011), Choi J (2011), Choi J (2011)	3
USP7	14	HUWE1	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014), Thompson JW (2014), Hein MY (2015)	4
USP7	14	RNF2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), de Bie P (2010), Gao Z (2012), Cao Q (2014), Lecona E (2015), Lecona E (2015), Hein MY (2015)	12
HIST3H2BB	0	RPL5	3	affinity chromatography technology, affinity chromatography technology	Choi J (2011), Choi J (2011)	2
HUWE1	22	MCM2	3	affinity chromatography technology	Thompson JW (2014)	1
HIST1H3B	3	CBX5	3	affinity chromatography technology	Foltz DR (2006)	1
CDKN2A	1	CENPA	0	two hybrid	Daakour S (2016)	1
CENPA	0	HIST3H2BB	0	affinity chromatography technology	Foltz DR (2006)	1
USP7	14	HIST3H2BB	0	enzymatic study	van der Knaap JA (2005)	1
RNF2	1	CDKN2A	1	affinity chromatography technology	de Bie P (2012)	1
RNF2	1	HIST3H2BB	0	affinity chromatography technology	Cao Q (2014)	1
CBX5	3	HIST3H2BB	0	pull down	Nielsen AL (2001)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
RNF2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
USP7	14	MCM5	1	affinity chromatography technology	Sowa ME (2009)	1
MCM5	1	CDKN2A	1	pull down	Ramachandran N (2004)	1
RNF2	1	MCM5	1	affinity chromatography technology	Cao Q (2014)	1
CBX5	3	RPL5	3	affinity chromatography technology	Nozawa RS (2010)	1