PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ACTN1	5	ACTN4	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
COL17A1	3	ACTN1	5	two hybrid, affinity chromatography technology	Gonzalez AM (2001), Gonzalez AM (2001)	2
CDH1	4	KRT18	2	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
COL17A1	3	DST	13	imaging technique, two hybrid, two hybrid	Koster J (2003), Koster J (2003), Hopkinson SB (2000)	3
CDH1	4	COL17A1	3	bioid	Guo Z (2014)	1
DST	13	ITGB4	11	two hybrid	Hopkinson SB (2000)	1
EGFR	5	ACTN4	4	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
COL17A1	3	PPL	6	two hybrid	Aho S (1998)	1
CDH1	4	PPL	6	bioid	Guo Z (2014)	1
COL17A1	3	KRT18	2	two hybrid, pull down	Aho S (1999), Aho S (1999)	2
COL17A1	3	CTNND1	4	two hybrid, pull down	Aho S (1999), Aho S (1999)	2
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
CDH1	4	DST	13	bioid	Guo Z (2014)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
EGFR	5	CTNND1	4	pull down, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Shrestha H (2016)	7
EGFR	5	ITGB4	11	affinity chromatography technology	Li J (2013)	1
COL17A1	3	ITGB4	11	two hybrid, affinity chromatography technology	Aho S (1998), Schaapveld RQ (1998)	2
EGFR	5	COL17A1	3	affinity chromatography technology	Li J (2013)	1
COL17A1	3	ACTN4	4	two hybrid, affinity chromatography technology	Gonzalez AM (2001), Gonzalez AM (2001)	2
CDH1	4	ACTN4	4	affinity chromatography technology	Catimel B (2005)	1