PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
RIPK1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Fearns C (2006), Taipale M (2012)	2
HSP90AA1	7	TAB2	5	affinity chromatography technology	Gano JJ (2010)	1
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
NFKB2	3	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Scheinman RI (1993), Scheinman RI (1993), Yang CH (2005), Leung CH (2006)	5
XPO1	8	TNIP2	1	affinity chromatography technology	Kirli K (2015)	1
RIPK1	2	MAP3K8	2	affinity chromatography technology	Eliopoulos AG (2006)	1
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
MAP3K14	1	MAP3K8	2	affinity chromatography technology	Lin X (1999)	1
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
NFKB1	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), Wang J (2011), Li X (2015)	4
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
AKT1	1	MAP3K8	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kane LP (2002), Kane LP (2002), Kane LP (2002)	3
XPO1	8	MAP3K8	2	affinity chromatography technology	Kirli K (2015)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
NFKB2	3	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Scheinman RI (1993), Huttlin EL (2015), Huttlin EL (2017)	4
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
XPO1	8	RELA	1	affinity chromatography technology	Kirli K (2015)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
XPO1	8	CHUK	5	affinity chromatography technology	Kirli K (2015)	1
NFKB1	2	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Lang V (2004), Lang V (2004), Lang V (2004), Lang V (2004), Wang J (2011), Li X (2015)	7
HSP90AA1	7	KSR2	6	affinity chromatography technology	Taipale M (2012)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
XPO1	8	NFKB1	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
MAP3K8	2	STIP1	1	two hybrid	Wang J (2011)	1
MAP3K8	2	MAP2K4	3	enzymatic study	Salmeron A (1996)	1
MAP2K1	8	KSR2	6	affinity chromatography technology	Channavajhala PL (2003)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
MAP3K8	2	TRAF6	0	affinity chromatography technology	Chan H (2005)	1
ACY3	1	MAP3K8	2	two hybrid	Wang J (2011)	1
MAP3K8	2	CHUK	5	enzymatic study, affinity chromatography technology	Lin X (1999), Lin X (1999)	2
HSP90AA1	7	MAP3K14	1	affinity chromatography technology, affinity chromatography technology	Qing G (2007), Taipale M (2012)	2
TNIP2	1	CHUK	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Leotoing L (2011), Leotoing L (2011), Leotoing L (2011)	3
MAP3K8	2	KSR2	6	affinity chromatography technology, affinity chromatography technology	Channavajhala PL (2003), Channavajhala PL (2003)	2
NFKB2	3	TNIP2	1	affinity chromatography technology	Bouwmeester T (2004)	1
NFKB2	3	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liang C (2006), Xiao G (2004), Qing G (2007), Nadiminty N (2006)	4
REL	5	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Hansen SK (1994), Hansen SK (1994), Liss AS (2002), Liss AS (2002), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	8
XPO1	8	NFKB2	3	affinity chromatography technology	Kirli K (2015)	1
MAP3K8	2	TAB2	5	affinity chromatography technology	Chan H (2005)	1
CD40	3	CHUK	5	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
REL	5	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Huttlin EL (2017)	3
MAP3K8	2	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Eliopoulos AG (2002), Chan H (2005)	2
MAP3K8	2	NFKB1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Belich MP (1999), Bouwmeester T (2004), Belich MP (1999), Belich MP (1999), Lang V (2004), Lang V (2004), Eliopoulos AG (2006), Wang J (2011), So J (2015)	9
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
CD40	3	MAP3K8	2	affinity chromatography technology	Chan H (2005)	1
MAP3K8	2	RELA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Veena MS (2014), So J (2015)	3
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
TAB2	5	NFKB1	2	pull down, affinity chromatography technology	Baek SH (2002), Baek SH (2002)	2
CHUK	5	RELA	1	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Hoberg JE (2006), Buss H (2004), Li S (2011), Dan HC (2008), Huang WC (2007), Busch F (2012)	6
HSP90AA1	7	MAP3K8	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
AKT1	1	MAP2K4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Park HS (2002), Park HS (2002), Park HS (2002), Song JJ (2005), Song JJ (2005)	5
XPO1	8	REL	5	affinity chromatography technology	Kirli K (2015)	1
MAP3K8	2	TNIP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bouwmeester T (2004), Lang V (2004), Lang V (2004), Lang V (2004), So J (2015)	5
MAP3K8	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), So J (2015)	3
MAP3K8	2	MAP2K1	8	enzymatic study, enzymatic study	Salmeron A (1996), Eliopoulos AG (2006)	2
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
NFKB1	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Heissmeyer V (1999), Beinke S (2002), Beinke S (2002), Beinke S (2002)	4
REL	5	MAP3K8	2	affinity chromatography technology	Bouwmeester T (2004)	1
RIPK1	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma Q (2008), Ea CK (2006), Kanayama A (2004), Kanayama A (2004)	4
RELA	1	TNIP2	1	affinity chromatography technology	Bouwmeester T (2004)	1
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
MAP3K14	1	NFKB2	3	affinity chromatography technology, affinity chromatography technology	Xiao G (2001), Qing G (2007)	2