PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNAJC7	2	STIP1	1	affinity chromatography technology	Hein MY (2015)	1
FKBP8	1	HSPBP1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
SMAD9	0	MACO1	0	two hybrid	Colland F (2004)	1
EVC2	5	SEC63	3	bioid	Gupta GD (2015)	1
EVC2	5	NUP155	2	bioid	Gupta GD (2015)	1
EVC2	5	CYP51A1	2	bioid	Gupta GD (2015)	1
DNAJC7	2	BAG2	0	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	YWHAH	0	bioid	Gupta GD (2015)	1
EVC2	5	PLD3	0	bioid	Gupta GD (2015)	1
ATP6AP2	2	JPH1	0	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	LBR	1	bioid	Gupta GD (2015)	1
STX5	0	SCFD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	SCFD1	1	bioid	Gupta GD (2015)	1
STUB1	4	HSPBP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arndt V (2005), Alberti S (2004), Alberti S (2004)	3
SRPRB	0	THEM6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPRB	0	VRK2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	TMEM199	0	bioid	Gupta GD (2015)	1
CDC37	0	UNC45A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
EVC2	5	TRIM13	1	bioid	Gupta GD (2015)	1
EVC2	5	ISOC1	2	bioid	Gupta GD (2015)	1
EVC2	5	SLC33A1	1	bioid	Gupta GD (2015)	1
EVC2	5	DNAJC7	2	bioid	Gupta GD (2015)	1
SRPRB	0	DHRS7	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	NDC1	0	bioid	Gupta GD (2015)	1
CAMLG	0	NUDC	1	genetic interference	Horlbeck MA (2018)	1
EVC2	5	CDC37	0	bioid	Gupta GD (2015)	1
CDC37	0	DNAJC7	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
NUDCD2	2	TTC1	3	biochemical	Havugimana PC (2012)	1
EVC2	5	POR	1	bioid	Gupta GD (2015)	1
EVC2	5	ATP6AP1	0	bioid	Gupta GD (2015)	1
EVC2	5	VMA21	0	bioid	Gupta GD (2015)	1
EVC2	5	FNDC3A	3	bioid	Gupta GD (2015)	1
EVC2	5	SPCS3	0	bioid	Gupta GD (2015)	1
RPN1	2	CCDC47	2	biochemical	Wan C (2015)	1
EVC2	5	SUGT1	1	bioid	Gupta GD (2015)	1
EVC2	5	MLXIPL	3	bioid	Gupta GD (2015)	1
BANF1	0	EVC2	5	affinity chromatography technology	Montes de Oca R (2009)	1
SMAD9	0	UNC45A	1	two hybrid	Colland F (2004)	1
EMC2	3	CKAP4	0	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	NUDCD3	0	bioid	Gupta GD (2015)	1
EVC2	5	STX5	0	bioid	Gupta GD (2015)	1
EVC2	5	CDKAL1	2	bioid	Gupta GD (2015)	1
STIP1	1	BAG2	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ESYT1	3	TMX1	4	affinity chromatography technology	Boldt K (2016)	1
CDC37	0	GLMN	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
EVC2	5	NUDC	1	bioid	Gupta GD (2015)	1
EVC2	5	UBE2J1	1	bioid	Gupta GD (2015)	1
EVC2	5	TMX1	4	bioid	Gupta GD (2015)	1
EVC2	5	SRPRA	3	bioid	Gupta GD (2015)	1
EVC2	5	STUB1	4	bioid	Gupta GD (2015)	1
ATP6AP2	2	SCFD1	1	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	ACBD3	1	bioid	Gupta GD (2015)	1
EVC2	5	EMD	0	bioid	Gupta GD (2015)	1
EVC2	5	VANGL1	2	bioid	Gupta GD (2015)	1
EVC2	5	SOAT1	3	bioid	Gupta GD (2015)	1
EVC2	5	ATP6AP2	2	bioid	Gupta GD (2015)	1
SOAT1	3	EMD	0	affinity chromatography technology	Malty RH (2017)	1
ISOC1	2	YWHAH	0	biochemical	Kristensen AR (2012)	1
EVC2	5	CLCC1	4	bioid	Gupta GD (2015)	1
EVC2	5	NSDHL	0	bioid	Gupta GD (2015)	1
EVC2	5	PTPN1	2	bioid	Gupta GD (2015)	1
EVC2	5	PGRMC2	1	bioid	Gupta GD (2015)	1
EVC2	5	RPN1	2	bioid	Gupta GD (2015)	1
EVC2	5	ACSL3	1	bioid	Gupta GD (2015)	1
RPN1	2	STT3B	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FKBP8	1	SUGT1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
EVC2	5	VRK2	1	bioid	Gupta GD (2015)	1
EVC2	5	SEC24B	3	bioid	Gupta GD (2015)	1
ATP6AP2	2	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
TTC1	3	BAG2	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
SRPRB	0	DDRGK1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	HMOX2	0	bioid	Gupta GD (2015)	1
EVC2	5	SPCS2	2	bioid	Gupta GD (2015)	1
EVC2	5	TTC1	3	bioid	Gupta GD (2015)	1
EVC2	5	SRPRB	0	bioid	Gupta GD (2015)	1
EMC2	3	NUDC	1	genetic interference	Horlbeck MA (2018)	1
EVC2	5	BAG2	0	bioid	Gupta GD (2015)	1
EVC2	5	LMBR1L	4	bioid	Gupta GD (2015)	1
EVC2	5	UNC45A	1	bioid	Gupta GD (2015)	1
SRPRB	0	POR	1	affinity chromatography technology	Huttlin EL (2015)	1
EVC2	5	GLMN	2	bioid	Gupta GD (2015)	1
EVC2	5	EMC2	3	bioid	Gupta GD (2015)	1
EVC2	5	CAMLG	0	bioid	Gupta GD (2015)	1
EVC2	5	VEZT	0	bioid	Gupta GD (2015)	1
ATP6AP2	2	FKBP8	1	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	ESYT1	3	bioid	Gupta GD (2015)	1
EVC2	5	CKAP4	0	bioid	Gupta GD (2015)	1
EVC2	5	FKBP8	1	bioid	Gupta GD (2015)	1
TMEM199	0	VMA21	0	affinity chromatography technology	Huttlin EL (2017)	1
SOAT1	3	BANF1	0	affinity chromatography technology	Malty RH (2017)	1
DDRGK1	1	SRPRA	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPRB	0	SRPRA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
EVC2	5	PREB	0	bioid	Gupta GD (2015)	1
ATP6AP1	0	NUDC	1	genetic interference	Horlbeck MA (2018)	1
EVC2	5	SEC11A	0	bioid	Gupta GD (2015)	1
EVC2	5	HSPBP1	0	bioid	Gupta GD (2015)	1
MAGT1	1	STT3B	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Lin DL (2017)	3
EVC2	5	MACO1	0	bioid	Gupta GD (2015)	1
EVC2	5	CCDC47	2	bioid	Gupta GD (2015)	1
EVC2	5	UBXN4	0	bioid	Gupta GD (2015)	1
EVC2	5	ST7	2	bioid	Gupta GD (2015)	1
ATP6AP2	2	VMA21	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	ALDH3A2	1	bioid	Gupta GD (2015)	1
SLC33A1	1	MACO1	0	affinity chromatography technology	Hein MY (2015)	1
DNAJC7	2	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	DDRGK1	1	bioid	Gupta GD (2015)	1
STUB1	4	BAG2	0	pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai Q (2005), Dai Q (2005), Arndt V (2005), Arndt V (2005), Arndt V (2005), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	9
ATP6AP2	2	TMEM199	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EVC2	5	AHCY	5	bioid	Gupta GD (2015)	1
EVC2	5	DHRS7	2	bioid	Gupta GD (2015)	1
SRPRB	0	TTC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6AP2	2	CKAP4	0	affinity chromatography technology	Hein MY (2015)	1
ACTR2	2	HSPBP1	0	biochemical, biochemical	Kristensen AR (2012), Wan C (2015)	2
SMAD9	0	DNAJC7	2	two hybrid	Colland F (2004)	1
SLC33A1	1	CKAP4	0	affinity chromatography technology	Hein MY (2015)	1
ATP6AP2	2	ATP6AP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
EVC2	5	ACTR2	2	bioid	Gupta GD (2015)	1
EVC2	5	RABL3	0	bioid	Gupta GD (2015)	1
EVC2	5	MOGS	3	bioid	Gupta GD (2015)	1
EVC2	5	BCAP31	0	bioid	Gupta GD (2015)	1
EVC2	5	STIM1	1	bioid	Gupta GD (2015)	1
EVC2	5	GYS1	1	bioid	Gupta GD (2015)	1
EMD	0	CDC37	0	affinity chromatography technology	Holaska JM (2007)	1
EVC2	5	JPH1	0	bioid	Gupta GD (2015)	1
EVC2	5	TOR1AIP1	2	bioid	Gupta GD (2015)	1
ACBD3	1	UNC45A	1	biochemical	Kristensen AR (2012)	1
CDC37	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
SRPRB	0	STX5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6AP2	2	RABL3	0	affinity chromatography technology	Hein MY (2015)	1
SRPRB	0	CYP51A1	2	affinity chromatography technology	Huttlin EL (2015)	1
EVC2	5	GRM5	6	bioid	Gupta GD (2015)	1
ATP6AP2	2	ACTR2	2	affinity chromatography technology	Hein MY (2015)	1
EVC2	5	STT3B	1	bioid	Gupta GD (2015)	1
TRIM13	1	CKAP4	0	affinity chromatography technology	Huttlin EL (2017)	1
PTPN1	2	CCDC47	2	affinity chromatography technology	Li X (2016)	1
GLMN	2	ANKLE2	5	affinity chromatography technology	Huttlin EL (2017)	1
ATP6AP1	0	EMC2	3	genetic interference	Horlbeck MA (2018)	1
EVC2	5	STIP1	1	bioid	Gupta GD (2015)	1
EVC2	5	MAGT1	1	bioid	Gupta GD (2015)	1
HMOX2	0	PTPN1	2	affinity chromatography technology	Huttlin EL (2015)	1
EVC2	5	ANKLE2	5	bioid	Gupta GD (2015)	1
NUDCD2	2	STUB1	4	biochemical	Havugimana PC (2012)	1
SMAD9	0	EVC2	5	two hybrid	Colland F (2004)	1
EVC2	5	SMPD4	3	bioid	Gupta GD (2015)	1
EVC2	5	THEM6	0	bioid	Gupta GD (2015)	1
EMD	0	BANF1	0	affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology	Holaska JM (2007), Lee KK (2001), Lee KK (2001), Tifft KE (2009), Tifft KE (2009)	5
EVC2	5	NUDCD2	2	bioid	Gupta GD (2015)	1