PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AHR	3	NCOA7	0	pull down	Nguyen TA (1999)	1
NCOA7	0	ESR1	0	pull down, pull down	Shao W (2002), Lazennec G (1997)	2
GABARAP	0	NCOA7	0	affinity chromatography technology	Behrends C (2010)	1
NCOA7	0	RAB3GAP1	5	biochemical	Kristensen AR (2012)	1
ARNT	1	AHR	3	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lindebro MC (1995), Lindebro MC (1995), Whitelaw M (1993), Yamaguchi Y (1995), Mimura J (1999), Mimura J (1999), Nakata A (2009), Elferink CJ (2001), Chen HS (2012), Zhang T (2010), Dougherty EJ (2008), Huttlin EL (2017), Singh SS (1996), Lando D (2000), Sadek CM (2000), Kumar MB (2001), Bacsi SG (1996), Klinge CM (1999), Reisz-Porszasz S (1994), Ohtake F (2007), Wang BJ (2013), Wang BJ (2013), Heid SE (2000)	23
AHR	3	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wormke M (2003), Klinge CM (2000), MacPherson L (2009), Beischlag TV (2005), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	8
ARNT	1	NCOA7	0	pull down	Nguyen TA (1999)	1
NCOA7	0	GABPA	0	biochemical	Kristensen AR (2012)	1
ATP6V1B1	4	NCOA7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GABPA	0	RAB3GAP1	5	biochemical	Kristensen AR (2012)	1
ARNT	1	ESR1	0	pull down	Beischlag TV (2005)	1