PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D3	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
TRIM50	1	UBE2E2	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM50	1	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
SQSTM1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji K (2012), Yan J (2013), Yan J (2013), Chen Q (2015)	4
TRIM50	1	UBE2E1	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
SQSTM1	0	UBE2D3	1	two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
TRIM50	1	TNK2	7	affinity chromatography technology, affinity chromatography technology	Fusco C (2014), Fusco C (2014)	2
TRIM50	1	UBE2N	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM50	1	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fusco C (2012), Fusco C (2014), Fusco C (2014)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TRIM50	1	SQSTM1	0	affinity chromatography technology	Fusco C (2012)	1
UBE2E1	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
TRIM50	1	UBE2D3	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM50	1	UBE2D1	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
UBE2D1	0	HDAC6	0	enzymatic study	Hoeller D (2007)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
TRIM50	1	UBE2D2	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM50	1	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TNK2	7	SQSTM1	0	affinity chromatography technology, imaging technique	Jones S (2014), Jones S (2014)	2