PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
MCM2	3	MAPK1	1	affinity chromatography technology	Drissi R (2015)	1
PTPN11	20	MTPN	0	biochemical	Kristensen AR (2012)	1
MTPN	0	REL	5	pull down, affinity chromatography technology	Knuefermann P (2002), Knuefermann P (2002)	2
RBBP4	3	DPY30	1	affinity chromatography technology	Hauri S (2016)	1
DCTN1	6	MTPN	0	bioid	Gupta GD (2015)	1
MTAP	3	RAB1A	0	biochemical	Kristensen AR (2012)	1
SOD1	0	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
OXCT1	1	MTPN	0	biochemical	Kristensen AR (2012)	1
SPICE1	2	MTPN	0	bioid	Gupta GD (2015)	1
CNTRL	5	CEP170	4	bioid	Gupta GD (2015)	1
MTPN	0	PIP4K2C	7	biochemical	Wan C (2015)	1
PDIA3	0	MTPN	0	biochemical	Kristensen AR (2012)	1
ELAVL1	0	CEP164	6	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM14	1	RBBP4	3	bioid	Tan P (2017)	1
OXCT1	1	PTPN11	20	biochemical	Kristensen AR (2012)	1
CEP170	4	MTPN	0	bioid	Gupta GD (2015)	1
RAB1A	0	MTPN	0	biochemical	Kristensen AR (2012)	1
MTPN	0	PIP4K2A	0	biochemical	Wan C (2015)	1
RBBP4	3	MTPN	0	biochemical	Kristensen AR (2012)	1
TRIM14	1	NPLOC4	4	bioid	Tan P (2017)	1
MTPN	0	GARS	1	biochemical	Wan C (2015)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
RAB1A	0	ATP6V1A	3	biochemical	Kristensen AR (2012)	1
CEP164	6	MTPN	0	bioid	Gupta GD (2015)	1
ATP6V1A	3	RBBP4	3	biochemical	Kristensen AR (2012)	1
ZNF131	0	MTPN	0	affinity chromatography technology	Varier RA (2016)	1
ELAVL1	0	MTPN	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ATP6V1A	3	MTPN	0	biochemical	Kristensen AR (2012)	1
PIP4K2A	0	PIP4K2C	7	affinity chromatography technology	Huttlin EL (2017)	1
DSTYK	1	MTPN	0	affinity chromatography technology	Ewing RM (2007)	1
DCTN1	6	DSTYK	1	affinity chromatography technology	Huttlin EL (2017)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
GARS	1	UBA1	1	biochemical	Havugimana PC (2012)	1
SOD1	0	MCM2	3	affinity chromatography technology	Malty RH (2017)	1
MAPK1	1	MTPN	0	two hybrid	Bandyopadhyay S (2010)	1
SOD1	0	UBA1	1	affinity chromatography technology	Malty RH (2017)	1
MCM2	3	MTPN	0	affinity chromatography technology	Drissi R (2015)	1
SOD1	0	NUP93	5	affinity chromatography technology	Malty RH (2017)	1
TRIM14	1	NFKB1	2	bioid	Tan P (2017)	1
ATP6V1A	3	PDIA3	0	biochemical	Kristensen AR (2012)	1
SASS6	1	MTPN	0	bioid	Gupta GD (2015)	1
OXCT1	1	SOD1	0	biochemical	Wan C (2015)	1
TRIM14	1	NUP93	5	bioid	Tan P (2017)	1
ELAVL1	0	ATP6V1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP170	4	DSTYK	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OTUB1	0	NUP93	5	affinity chromatography technology	Scholz CC (2016)	1
CNTRL	5	MTPN	0	bioid	Gupta GD (2015)	1
RBBP4	3	PDIA3	0	biochemical	Kristensen AR (2012)	1
OTUB1	0	MTPN	0	affinity chromatography technology	Scholz CC (2016)	1
SASS6	1	CEP170	4	bioid	Gupta GD (2015)	1
ELAVL1	0	PIP4K2C	7	affinity chromatography technology	Abdelmohsen K (2009)	1
MTPN	0	RELA	1	pull down, affinity chromatography technology	Knuefermann P (2002), Knuefermann P (2002)	2
SOD1	0	ATP6V1A	3	affinity chromatography technology	Malty RH (2017)	1
ZNF131	0	DPY30	1	affinity chromatography technology	Varier RA (2016)	1
CEP290	5	MTPN	0	bioid	Gupta GD (2015)	1
DCTN1	6	NPLOC4	4	bioid	Gupta GD (2015)	1
REL	5	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Hansen SK (1994), Hansen SK (1994), Liss AS (2002), Liss AS (2002), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	8
TRIM14	1	MTPN	0	bioid	Tan P (2017)	1
CNTROB	6	MTPN	0	bioid	Gupta GD (2015)	1
CEP170	4	DCTN1	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	MTPN	0	bioid	Gupta GD (2015)	1
MTPN	0	UBA1	1	biochemical	Wan C (2015)	1
CEP290	5	UBA1	1	affinity chromatography technology	Gupta GD (2015)	1
MCM2	3	PDIA3	0	affinity chromatography technology	Drissi R (2015)	1
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MTPN	0	NFKB1	2	pull down	Knuefermann P (2002)	1
ELAVL1	0	NUP93	5	affinity chromatography technology	Abdelmohsen K (2009)	1
UBA1	1	NUP93	5	biochemical	Wan C (2015)	1
GARS	1	NPLOC4	4	biochemical	Wan C (2015)	1
MTPN	0	DPY30	1	biochemical	Wan C (2015)	1
OTUB1	0	MAPK1	1	affinity chromatography technology	Scholz CC (2016)	1
NUP93	5	MTPN	0	biochemical	Wan C (2015)	1
ELAVL1	0	MTAP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MCM2	3	MTAP	3	affinity chromatography technology	Drissi R (2015)	1
MTAP	3	ATP6V1A	3	biochemical	Kristensen AR (2012)	1
MCM2	3	NPLOC4	4	affinity chromatography technology	Drissi R (2015)	1
SOD1	0	PDIA3	0	affinity chromatography technology	Malty RH (2017)	1
MTAP	3	PDIA3	0	biochemical	Kristensen AR (2012)	1
SPICE1	2	GARS	1	bioid	Gupta GD (2015)	1
ELAVL1	0	PTPN11	20	affinity chromatography technology	Abdelmohsen K (2009)	1
CNTRL	5	PDIA3	0	bioid	Gupta GD (2015)	1
CEP135	2	CEP170	4	bioid	Gupta GD (2015)	1
MTPN	0	NPLOC4	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MTAP	3	MTPN	0	biochemical	Kristensen AR (2012)	1
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
UBA1	1	NPLOC4	4	biochemical	Wan C (2015)	1
SOD1	0	MTPN	0	affinity chromatography technology	Malty RH (2017)	1
ELAVL1	0	NPLOC4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RAB1A	0	PDIA3	0	biochemical	Kristensen AR (2012)	1
TMEM237	1	MTPN	0	bioid	Gupta GD (2015)	1
ELAVL1	0	RAB1A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CEP170	4	MTAP	3	bioid	Gupta GD (2015)	1
CEP290	5	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PDIA3	0	GARS	1	biochemical	Havugimana PC (2012)	1