PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MIA2	5	CREM	1	affinity chromatography technology	Huttlin EL (2017)	1
KCNIP3	1	CREB1	1	affinity chromatography technology	Ledo F (2002)	1
CREM	1	TBP	0	pull down	Inada A (1999)	1
CREM	1	TAF4	4	pull down	Inada A (1999)	1
TAF4	4	CREB1	1	affinity chromatography technology	Mayr BM (2005)	1
TBP	0	CREBBP	29	affinity chromatography technology	Dallas PB (1997)	1
CDC34	3	CREM	1	two hybrid	Pati D (1999)	1
HDAC1	4	CASP8AP2	3	affinity chromatography technology	Huttlin EL (2017)	1
TBP	0	TAF4	4	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Pointud JC (2003), Bellorini M (1997), Knuesel MT (2009), Liu X (2008), Dikstein R (1996), Wieczorek E (1998), Dantonel JC (1997), Kamileri I (2012), Havugimana PC (2012), Ogryzko VV (1998)	10
HDAC1	4	SPI1	1	affinity chromatography technology, pull down, affinity chromatography technology	Suzuki M (2003), Suzuki M (2006), Kihara-Negishi F (2001)	3
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
DNMT3L	2	CREM	1	pull down	Pacaud R (2014)	1
CREM	1	HDAC1	4	affinity chromatography technology, pull down, pull down	Tenbrock K (2006), Tenbrock K (2006), Tenbrock K (2006)	3
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
RBPJ	1	CREM	1	affinity chromatography technology	Li X (2015)	1
HDAC1	4	TBP	0	affinity chromatography technology	Wu Y (2001)	1
CREM	1	UBE2I	0	two hybrid	Wang J (2011)	1
DNMT3L	2	CREB1	1	pull down	Pacaud R (2014)	1
MAPK3	4	CREM	1	enzymatic study	Yehia G (2001)	1
CASP8AP2	3	CREM	1	two hybrid	Wang J (2011)	1
FOXL2	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kuo FT (2009), Kuo FT (2009), Kuo FT (2009)	3
CREB3L4	0	CREM	1	affinity chromatography technology	Nagamori I (2006)	1
UBE2I	0	SP100	4	enzymatic study, pull down, two hybrid, enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Knipscheer P (2008), Bandyopadhyay S (2010), Pelisch F (2010), Meulmeester E (2008), Knipscheer P (2007)	6
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
CREBBP	29	PIAS3	2	affinity chromatography technology	Long J (2004)	1
RBPJ	1	TBP	0	affinity chromatography technology	Li X (2015)	1
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
TSNAX	1	CREM	1	affinity chromatography technology	Hein MY (2015)	1
CREM	1	PIAS3	2	two hybrid	Wang J (2011)	1
FOXL2	1	CREM	1	affinity chromatography technology	LHote D (2012)	1
MIA2	5	CREB1	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXL2	1	SP100	4	affinity chromatography technology	LHote D (2012)	1
CREB1	1	FHL5	0	two hybrid, affinity chromatography technology	Fimia GM (2000), Fimia GM (2000)	2
UBE2I	0	TBP	0	enzymatic study	Boyer-Guittaut M (2005)	1
SPI1	1	CREM	1	pull down	Pongubala JM (1995)	1
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
KCNIP3	1	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Palczewska M (2011), Palczewska M (2011), Palczewska M (2011)	3
TBP	0	SPI1	1	affinity chromatography technology, pull down	Kihara-Negishi F (2001), Hagemeier C (1993)	2
CREM	1	SP100	4	two hybrid	Wang J (2011)	1
CREBBP	29	CREB1	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, pull down, far western blotting, pull down, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi Y (2004), Kim J (2005), Shimomura A (1996), Radhakrishnan I (1997), Radhakrishnan I (1997), Sano Y (1998), Sano Y (1998), Zor T (2002), Giebler HA (2000), Zhang Q (2000), Ernst P (2001), Ledo F (2002), Poon SL (2008), Best JL (2004), Best JL (2004), Chan EC (2010), Yang F (2006), Solomou EE (2001), Du K (1998), Venza I (2001), Lundblad JR (1995), Lundblad JR (1995), Arias J (1994), Chrivia JC (1993), Chrivia JC (1993), Shi Y (2004), Ramirez JA (2007), Sun HS (2003), Sun HS (2003), Wang Y (2016)	30
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
UBE2I	0	TSNAX	1	enzymatic study	Gocke CB (2005)	1
CREM	1	EMP3	0	two hybrid	Wang J (2011)	1
KCNIP3	1	CREM	1	pull down	Ledo F (2000)	1
RAD18	3	CREM	1	affinity chromatography technology	Hein MY (2015)	1
ATXN1	2	CREM	1	two hybrid	Suter B (2013)	1
UBE2I	0	RAD18	3	two hybrid	Markson G (2009)	1
CREBBP	29	CREM	1	pull down	Laurance ME (1997)	1
FHL5	0	CREM	1	two hybrid, two hybrid, pull down, affinity chromatography technology	Fimia GM (2000), Fimia GM (1999), Fimia GM (1999), Fimia GM (1999)	4
CREB1	1	CREM	1	affinity chromatography technology, affinity chromatography technology	Srivastava V (2012), Li X (2015)	2