PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BTRC	1	ARIH1	3	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
ARIH1	3	FBXW2	0	affinity chromatography technology	Huttlin EL (2017)	1
SPANXN3	0	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW2	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xu J (2017), Xu J (2017), Xu J (2017), Huttlin EL (2017)	4
SPANXN3	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
SPANXN3	0	APP	1	pull down	Olah J (2011)	1
SPANXN3	0	SUOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
CUL1	7	ARIH1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Kelsall IR (2013), Kelsall IR (2013), Huttlin EL (2017)	4
SPANXN3	0	CUL1	7	affinity chromatography technology	Huttlin EL (2017)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
SPANXN3	0	EHD1	5	affinity chromatography technology	Huttlin EL (2015)	1
SPANXN3	0	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SPANXN3	0	ARIH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	ARIH1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kim TY (2014), Low TY (2014), Huttlin EL (2017)	4
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
SPANXN3	0	IMPDH1	2	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4	2	SPANXN3	0	enzymatic study	Persaud A (2009)	1
SPANXN3	0	CMSS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	CUL1	7	affinity chromatography technology	Liu J (2014)	1
FBXW2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Saiga T (2009), Bennett EJ (2010), Busino L (2003), Liu B (2012), Low TY (2014), Xu J (2017), Reitsma JM (2017)	8