PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APC	5	XPO1	8	affinity chromatography technology, pull down	Tickenbrock L (2002), Tickenbrock L (2002)	2
MRPL4	1	AMER1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CTNNA3	3	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	LATS2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe	Yabuta N (2011), Toji S (2004), Toji S (2004), Toji S (2004), Toji S (2004), Ivanov AA (2017)	6
EGLN3	0	AXIN1	1	affinity chromatography technology	Rodriguez J (2016)	1
CEP250	4	APC	5	affinity chromatography technology	Fogeron ML (2013)	1
AMER1	0	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Major MB (2007), Kim TY (2014), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	5
BTRC	1	MRPL4	1	affinity chromatography technology	Coyaud E (2015)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
APC	5	AMER1	0	affinity chromatography technology	Hein MY (2015)	1
TSPYL1	3	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	LATS2	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	IQCN	0	affinity chromatography technology	Fei T (2017)	1
FBXW11	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
AURKA	1	BTRC	1	affinity chromatography technology	Irelan JT (2007)	1
HNRNPL	3	FBXW11	2	affinity chromatography technology	Fei T (2017)	1
EGLN3	0	KEAP1	0	affinity chromatography technology	Rodriguez J (2016)	1
KEAP1	0	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaspar JW (2012), Kaspar JW (2012), Kirli K (2015)	3
FBXW11	2	KEAP1	0	affinity chromatography technology	Kim TY (2014)	1
AURKA	1	CTNNB1	30	affinity chromatography technology	Hein MY (2015)	1
CPA6	0	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
SRPK2	1	AMER1	0	enzymatic study	Lipp JJ (2015)	1
EGLN3	0	TSPYL1	3	affinity chromatography technology	Rodriguez J (2016)	1
TSPYL6	0	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	AMER1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP2M1	5	APC	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
RAF1	3	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BTRC	1	KEAP1	0	affinity chromatography technology, bioid	Sowa ME (2009), Coyaud E (2015)	2
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	CTNNB1	30	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	AMER1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kitagawa M (1999), Hart M (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Novellasdemunt L (2017)	7
XPO1	8	AXIN1	1	affinity chromatography technology	Kirli K (2015)	1
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
LATS2	1	CTNNB1	30	bioid, affinity chromatography technology, affinity chromatography technology, pull down	Couzens AL (2013), Li J (2013), Li J (2013), Li J (2013)	4
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
IQCN	0	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
XPO1	8	AMER1	0	affinity chromatography technology	Kirli K (2015)	1
AP2M1	5	AMER1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
EGLN3	0	AMER1	0	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	AMER1	0	affinity chromatography technology	Fei T (2017)	1
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
AXIN1	1	APC	5	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hino S (2005), Kitagawa M (1999), Sue Ng S (2010), Tran H (2012), Li VS (2012), Hein MY (2015), Hein MY (2015), Novellasdemunt L (2017)	12
AMER1	0	AXIN1	1	pull down, affinity chromatography technology, affinity chromatography technology	Major MB (2007), Sue Ng S (2010), Hein MY (2015)	3
CTNNA3	3	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
ZNF408	0	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TULP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
ELAVL1	0	TSPYL1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
AMER1	0	FBXW11	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Major MB (2007), Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017), Camp ND (2012)	6
SRPK2	1	AURKA	1	enzymatic study	Varjosalo M (2013)	1
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
ZNF408	0	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
IQCN	0	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXW11	2	MRPL4	1	affinity chromatography technology	Coyaud E (2015)	1
FRMD1	1	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
TULP2	1	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
LATS2	1	APC	5	bioid	Couzens AL (2013)	1
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
CTNNA3	3	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Janssens B (2001), Waaijers S (2013), Chen TC (2014), Huttlin EL (2017)	4
CEP250	4	AMER1	0	affinity chromatography technology	Fogeron ML (2013)	1
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
AMER1	0	KEAP1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Major MB (2007), Camp ND (2012), Camp ND (2012), Camp ND (2012), Hast BE (2014), Hast BE (2014)	6
XPO1	8	RAF1	3	affinity chromatography technology	Kirli K (2015)	1
AP2M1	5	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
RAF1	3	KEAP1	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AMER1	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1
ELAVL1	0	LATS2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
LATS2	1	AMER1	0	bioid	Couzens AL (2013)	1
AMER1	0	CTNNB1	30	pull down, affinity chromatography technology	Major MB (2007), Hein MY (2015)	2