Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CRHR2	1395	SAUVAGINE	CHEMBL439883	agonist	GuideToPharmacologyInteractions
CRHR2	1395	WORTMANNIN	CHEMBL428496	agonist, antagonist	TdgClinicalTrial, GuideToPharmacologyInteractions, TTD
CRHR2	1395	CHEMBL1236539	CHEMBL1236539	agonist	GuideToPharmacologyInteractions
CRHR2	1395	NAPHTHALENE	CHEMBL16293	antagonist	GuideToPharmacologyInteractions
CRHR2	1395	ENTINOSTAT	CHEMBL27759	antagonist	TTD

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CRHR2	rs73294475	CT	salbutamol	efficacy	yes	The allele associated with increased response and low frequency is not explicitly stated. Response is increased for carriers of the rare, minor allele. GALAII genotyping was done using the Affymetrix LAT1 Array, which was designed to capture Latino population variation. This was assessed as a replication attempt for a previously reported association of a different CRHR2 SNP with response to bronchodilators. Bonferroni correction was performed according to the number of SNPs included that are within 50 kb up and downstream of CRHR2.	Genotype CT is associated with increased response to salbutamol in children with Asthma as compared to genotype TT.	23992748	1183680162
CRHR2	rs2284220	G	salbutamol	efficacy	yes		Allele G is associated with decreased response to salbutamol in people with Asthma as compared to allele A.	18408560	699639185
CRHR2	rs7793837	T	salbutamol	efficacy	no		Allele T is not associated with decreased response to salbutamol and selective beta-2-adrenoreceptor agonists in people with Asthma as compared to allele A.	18408560	1448634968
CRHR2	rs2267715	G	salbutamol	efficacy	yes		Allele G is associated with decreased response to salbutamol in people with Asthma as compared to allele A.	18408560	699639154
CRHR2	rs2267715	G	salbutamol	efficacy	no		Allele G is not associated with decreased response to salbutamol in people with Asthma as compared to allele A.	18408560	699639165
CRHR2	rs2284220	G	salbutamol	efficacy	no		Allele G is not associated with decreased response to salbutamol in people with Asthma as compared to allele A.	18408560	699639192
CRHR2	rs255100	A	salbutamol	efficacy	yes	The A allele of this variant is associated with reduced bronchodilator response in CAMP cohort. However, this association is not significant in the other two cohorts tested.	Allele A is associated with decreased response to salbutamol in people with Asthma as compared to allele T.	18408560	699639201
CRHR2	rs7793837	T	salbutamol	efficacy	yes		Allele T is associated with decreased response to salbutamol and selective beta-2-adrenoreceptor agonists in people with Asthma as compared to allele A.	18408560	655386940
CRHR2	rs7793837	T	salbutamol	efficacy	yes		Allele T is associated with decreased response to salbutamol and selective beta-2-adrenoreceptor agonists in people with Asthma as compared to allele A.	18408560	655386935
CRHR2	rs255100	A	salbutamol	efficacy	no	in replication cohort with adult patients.	Allele A is not associated with decreased response to salbutamol in people with Asthma as compared to allele T.	18408560	699639212
CRHR2	rs2270007	CC + CG	citalopram	efficacy	yes	This association is for response at week 4 but not at week 12. The allele associated with worse response is described as G. This is a G/C SNP, so this is ambiguous. The gene is on the negative chromosomal strand, so I am guessing that the authors meant negative chromosomal strand G (= positive chromosomal strand C). The OR entered is for increased risk of non-response. Authors note that Bonferroni correction was not done and that they think that it would be overly conservative to do so. p entered is not corrected; 7 SNPs were tested. Number of "cases" and "controls" entered are responders and non-responders.	Genotypes CC + CG are associated with decreased response to citalopram in people with Depressive Disorder, Major as compared to genotype GG.	17467808	982015348
CRHR2	rs255100	A	salbutamol	efficacy	no		Allele A is not associated with decreased response to salbutamol in people with Asthma as compared to allele T.	18408560	1448634923
CRHR2	rs2284220	G	salbutamol	efficacy	no		Allele G is not associated with decreased response to salbutamol in people with Asthma as compared to allele A.	18408560	1448634953