PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NOS3	7	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	TRIM23	3	two hybrid	Woodsmith J (2012)	1
RAB3D	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	IFIT5	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Pichlmair A (2011)	2
ECSIT	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
APOE	1	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
PRDX2	1	APP	1	pull down	Olah J (2011)	1
MAST1	9	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
NOS3	7	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APP	1	IFIT3	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
CDC37	0	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	APP	1	two hybrid	Soler-Lopez M (2011)	1
UBE2K	0	MKRN3	2	two hybrid	Markson G (2009)	1
IFIT3	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
RNF32	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
MNAT1	0	RNF32	0	two hybrid	Woodsmith J (2012)	1
ECSIT	3	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
MNAT1	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
A2M	8	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RPP30	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
IFIT3	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
PSEN2	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	MGEA5	3	two hybrid, biochemical, biochemical	Soler-Lopez M (2011), Kristensen AR (2012), Wan C (2015)	3
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
RAB3D	0	APP	1	pull down	Olah J (2011)	1
ECSIT	3	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FARSA	6	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	ELAVL3	3	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CDC37	0	affinity chromatography technology, two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NOS3	7	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
RAB3D	0	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
UBE2K	0	RNF32	0	two hybrid	Markson G (2009)	1
A2M	8	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	APOE	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RPP30	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
TRIM74	0	RNF32	0	two hybrid	Woodsmith J (2012)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
HOXC4	1	RNF32	0	two hybrid	Wang J (2011)	1
APOE	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LZTS2	4	two hybrid	Soler-Lopez M (2011)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
MAST1	9	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
A2M	8	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
APP	1	HOXC4	1	pull down	Virok DP (2011)	1
APP	1	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	STAMBPL1	2	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
BLMH	0	APP	1	pull down, biochemical	Lefterov IM (2000), Lefterov IM (2000)	2
PSEN1	11	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	FARSA	6	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRAM1	4	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	IFIT3	1	two hybrid, pull down, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
PSEN1	11	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
A2M	8	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOSC1	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
IFIT5	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
PAXIP1	1	MGEA5	3	affinity chromatography technology	Woods NT (2012)	1
EXOSC1	0	APP	1	pull down	Olah J (2011)	1
MAST1	9	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1