PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SP1	0	TBP	0	two hybrid, two hybrid, pull down, pull down	Loregian A (2003), Loregian A (2003), Schwarzenbach H (2014), Schwarzenbach H (2014)	4
HIST1H3A	3	CTCFL	0	far western blotting, pull down	Jelinic P (2006), Jelinic P (2006)	2
PRMT7	0	HIST1H3A	3	enzymatic study	Migliori V (2012)	1
HIST2H2AC	1	HIST1H3A	3	pull down, pull down, pull down	Hoffmann A (1996), Hoffmann A (1996), Boenisch C (2012)	3
EGFR	5	CTCFL	0	affinity chromatography technology	Yao Z (2017)	1
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
BRCA1	7	CTCFL	0	unspecified method	Rodriguez M (2003)	1
ZDHHC17	1	CTCFL	0	two hybrid	Butland SL (2014)	1
HIST2H2AC	1	CTCFL	0	far western blotting, pull down	Jelinic P (2006), Jelinic P (2006)	2
HIST1H1A	0	CTCFL	0	far western blotting, pull down	Jelinic P (2006), Jelinic P (2006)	2
CTCFL	0	TBP	0	pull down	Schwarzenbach H (2014)	1
AURKA	1	CTCFL	0	pull down	Kamran M (2017)	1
PRMT7	0	HIST2H2AC	1	enzymatic study	Jelinic P (2006)	1
AURKA	1	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Ouchi M (2004), Ouchi M (2004), Maxwell CA (2011), Maxwell CA (2011), Ouchi M (2004), Ouchi M (2004), Ertych N (2016)	7
CTCFL	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Nguyen P (2008), Nguyen P (2008), Nguyen P (2008)	3
BRCA1	7	HIST2H2AC	1	enzymatic study, enzymatic study	Chen A (2002), Thakar A (2010)	2
CTCFL	0	SP1	0	affinity chromatography technology, pull down	Kang Y (2007), Schwarzenbach H (2014)	2
CTCFL	0	PRMT7	0	pull down, pull down, affinity chromatography technology	Jelinic P (2006), Jelinic P (2006), Jelinic P (2006)	3