PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCL22	1	CRYAB	0	two hybrid	Wang J (2011)	1
CRYAB	0	CS	1	pull down, pull down	Rajaraman K (2001), Ghosh JG (2005)	2
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
CRYAB	0	IQGAP3	6	affinity chromatography technology	Huttlin EL (2015)	1
SOD1	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Choi JS (2004), Choi JS (2004), Urushitani M (2004), Ganesan S (2008), Malty RH (2017)	5
ALB	1	APP	1	pull down	Olah J (2011)	1
CRYAB	0	ALB	1	affinity chromatography technology	Rothbard JB (2011)	1
MIP	1	CRYAB	0	fluorescent resonance energy transfe	Liu BF (2008)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
CRYAB	0	CTNNB1	30	unspecified method, affinity chromatography technology, affinity chromatography technology	Ghosh JG (2007), Huang Z (2012), Huang Z (2012)	3
SNCA	0	MAP1B	5	pull down	Jensen PH (2000)	1
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
CRYAB	0	GEMIN4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRYAB	0	MDH2	0	pull down	Regini JW (2010)	1
HDAC1	4	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Johnson CA (2002), Johnson CA (2002)	2
ALB	1	APOC2	0	affinity chromatography technology	Zhou M (2004)	1
HSPB1	2	CASP3	0	affinity chromatography technology	Gibert B (2012)	1
HSPB8	0	CRYAB	0	two hybrid, fluorescent resonance energy transfe	Fontaine JM (2005), Fontaine JM (2005)	2
CRYAB	0	TRAPPC6A	0	two hybrid	Rolland T (2014)	1
CRYAB	0	INS	0	unspecified method	Ghosh JG (2007)	1
CDC23	3	TRIM33	4	affinity chromatography technology	Sedgwick GG (2012)	1
GFAP	0	APP	1	pull down	Olah J (2011)	1
SNCA	0	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kalia LV (2011), Huang C (2006), Huang C (2006), Lindersson E (2004), Kawakami F (2011), Pemberton S (2011), Klucken J (2006)	7
GDF5	0	BMPR2	1	pull down	Erlacher L (1998)	1
CRYAB	0	KRTAP8-1	0	two hybrid	Rolland T (2014)	1
ADAM2	1	TTN	102	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Jin X (2009), Watanabe G (2009)	2
TRIM33	4	SMAD4	9	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Agricola E (2011), Fattet L (2013), Bellaye PS (2014), Xue J (2014), Xue J (2014), Wu Y (2017)	6
TP53	0	BAX	3	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Kim EM (2014), Kim EM (2014)	3
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
XIAP	0	BCL2	0	pull down, enzymatic study	Edison N (2017), Edison N (2017)	2
TP53	0	FBXO21	2	affinity chromatography technology	Fogeron ML (2013)	1
HSPB1	2	DES	1	two hybrid	Katsogiannou M (2014)	1
APP	1	FCF1	0	pull down	Virok DP (2011)	1
MAS1	2	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
CRYAA	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
CRYAB	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
PSMD4	1	MDH2	0	affinity chromatography technology	Weekes J (2003)	1
CRYAB	0	CD40LG	0	affinity chromatography technology	Rothbard JB (2011)	1
HSPB1	2	INS	0	pull down	Rogalla T (1999)	1
CRYAB	0	UBE2D1	0	pull down	Lin DI (2006)	1
TRIM33	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xue J (2015), Xue J (2015), Xue J (2015)	3
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CRYAB	0	PSMA3	1	two hybrid, biochemical, affinity chromatography technology	Boelens WC (2001), Boelens WC (2001), Boelens WC (2001)	3
CRYAA	0	HSPB2	1	two hybrid, affinity chromatography technology	Fu L (2003), Fu L (2003)	2
BAX	3	CASP3	0	biochemical	Chandra D (2004)	1
CASP12	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CRYGC	0	CRYGD	1	two hybrid	Fu L (2003)	1
CRYAB	0	HSPB1	2	biochemical, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Kato K (1992), Kato K (1992), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003), MacIntyre DA (2008), Zhang H (2010), Delbecq SP (2012), Aquilina JA (2013), DeGrado-Warren J (2008), Huttlin EL (2015), Huttlin EL (2017)	13
CRYAB	0	CCDC85B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADAM2	1	CRYAB	0	affinity chromatography technology	Cottrell BA (2005)	1
CRYAA	0	CRYGD	1	two hybrid, pull down	Fu L (2003), Moreau KL (2012)	2
SOD1	0	SORD	2	biochemical	Wan C (2015)	1
CASP2	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
CASP6	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
TTN	102	CRYAB	0	affinity chromatography technology	Bullard B (2004)	1
SCN5A	9	NEDD4L	3	affinity chromatography technology	Luo L (2017)	1
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
BAG3	4	CRYAB	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hishiya A (2011), Hishiya A (2011), Hishiya A (2011), Huttlin EL (2015), Huttlin EL (2017)	5
BMPR2	1	XIAP	0	affinity chromatography technology	Liu Z (2009)	1
CRYAB	0	SMCR8	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	BCL2	0	pull down, affinity chromatography technology	Chen D (2010), Chen D (2010)	2
SCN5A	9	CRYAB	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Huang Y (2016), Huang Y (2016), Huang Y (2016), Huang Y (2016)	4
TFG	3	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
CASP12	1	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CDH1	4	TTN	102	bioid	Guo Z (2014)	1
CRYAA	0	CRYBB2	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003)	4
CDH1	4	BAG3	4	bioid	Guo Z (2014)	1
CRYAA	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CDH16	2	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Thedieck C (2008), Thedieck C (2008)	2
CRYAB	0	SORD	2	biochemical	Wan C (2015)	1
FCGR2A	0	CRYAB	0	pull down, affinity chromatography technology	Rothbard JB (2011), Rothbard JB (2011)	2
NEDD4L	3	SNCA	0	enzymatic study	Sugeno N (2014)	1
HSPA4	3	CRYAB	0	affinity chromatography technology	Chavez Zobel AT (2003)	1
CRYAB	0	CRYGD	1	two hybrid, pull down, pull down, pull down	Fu L (2003), Banerjee PR (2011), Ghosh JG (2005), Moreau KL (2012)	4
567	0	CRYAB	0	pull down	Esposito G (2013)	1
CRYAB	0	GFAP	0	pull down	Ghosh JG (2007)	1
PSMA3	1	MDH2	0	affinity chromatography technology	Fedorova OA (2011)	1
GMCL1	0	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
CASP7	1	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2012), Jeong WJ (2012)	2
CRYAA	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
PSMA3	1	ALB	1	affinity chromatography technology	Fedorova OA (2011)	1
HSPB1	2	HSPA4	3	two hybrid	Katsogiannou M (2014)	1
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
CRYAB	0	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SOD1	0	ACOT7	2	affinity chromatography technology	Malty RH (2017)	1
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
VEGFA	3	CRYAB	0	affinity chromatography technology, unspecified method	Ruan Q (2011), Ghosh JG (2007)	2
CASP2	1	BCL2	0	genetic interference	Guo Y (2002)	1
CRYAB	0	LENG8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRYAB	0	BCL2	0	affinity chromatography technology, affinity chromatography technology	Launay N (2010), Launay N (2010)	2
GDF5	0	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMD4	1	ALB	1	affinity chromatography technology	Weekes J (2003)	1
CRYAA	0	CRYBA1	0	pull down, imaging technique, two hybrid, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Gupta R (2009), Gupta R (2009), Gupta R (2009), Gupta R (2009), Tiwary E (2015), Tiwary E (2015)	6
CDH1	4	CCDC85C	0	bioid	Guo Z (2014)	1
CRADD	0	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
PSMA3	1	KRTAP8-1	0	two hybrid	Rolland T (2014)	1
CDH1	4	PI4KA	7	bioid	Guo Z (2014)	1
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
GFAP	0	DES	1	affinity chromatography technology	Huttlin EL (2017)	1
CRYAB	0	NGF	0	unspecified method	Ghosh JG (2007)	1
PRKN	1	MDH2	0	affinity chromatography technology	Sarraf SA (2013)	1
APP	1	TRAPPC9	6	pull down	Virok DP (2011)	1
CRYAB	0	ACOT7	2	two hybrid	Rolland T (2014)	1
PSMD4	1	APP	1	pull down	Olah J (2011)	1
BAG3	4	BAX	3	affinity chromatography technology	Chen Y (2013)	1
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
CRYAB	0	TRAPPC9	6	affinity chromatography technology	Huttlin EL (2015)	1
NEDD4L	3	UBE2D1	0	pull down, pull down, pull down, pull down	Schwarz SE (1998), Herhaus L (2013), Bosanac I (2011), Todaro DR (2017)	4
APOC2	0	CRYAB	0	pull down	Binger KJ (2013)	1
CRYAB	0	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	5
SNCA	0	CRYAB	0	pull down, x-ray crystallography, pull down, biochemical, pull down	Rekas A (2004), Rekas A (2004), Bruinsma IB (2011), Waudby CA (2010), Waudby CA (2010)	5
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
CRYAB	0	TRAPPC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRYAB	0	CRYBB2	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003), Ghosh JG (2005)	5
TP53	0	CCND1	1	affinity chromatography technology	Yang P (2016)	1
CRYAB	0	NYNRIN	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACOT7	2	SORD	2	biochemical	Kristensen AR (2012)	1
PRKAG3	1	CRYAB	0	two hybrid	Moreno D (2009)	1
UBE2D1	0	XIAP	0	two hybrid, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Markson G (2009), Hu S (2003), Dynek JN (2010), Morizane Y (2005), Janzer A (2012), Liu WH (2007), Takeda AN (2014), Markson G (2009), Hao Y (2004), Hanson AJ (2012)	10
CTNNB1	30	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
SOD1	0	ALB	1	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	BMPR2	1	bioid	Guo Z (2014)	1
NEDD4L	3	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Huang Y (2016), Huang Y (2016)	2
SNCA	0	HSPB8	0	pull down	Bruinsma IB (2011)	1
SOD1	0	MDH2	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
HSPB8	0	HSPB1	2	two hybrid, affinity chromatography technology	Sun X (2004), Irobi J (2004)	2
PSMD4	1	SOD1	0	affinity chromatography technology	Choi JS (2004)	1
NUDT16L1	4	APP	1	pull down	Olah J (2011)	1
CRYAB	0	LALBA	0	pull down	Regini JW (2010)	1
CRYBB2	1	CRYGC	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Fu L (2002), Fu L (2002), Fu L (2002), Fu L (2003)	4
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
PRKN	1	ALB	1	affinity chromatography technology	Zanon A (2013)	1
CRYAB	0	VPS33A	0	affinity chromatography technology	Huttlin EL (2015)	1
G3BP1	4	CRYAB	0	affinity chromatography technology	Jain S (2016)	1
TP53	0	BCL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo KS (2011), Jung JH (2011), Jung JH (2011), Mancini F (2009), Mancini F (2009)	5
BCL2L1	0	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vinayagam A (2011), Tang WH (2014), Saxena R (2016), Stegh AH (2010), Kim EM (2014)	5
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
BAG3	4	HSPA4	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doong H (2003), Doong H (2003), Gentilella A (2011), Gamerdinger M (2009), Gamerdinger M (2009), Ammirante M (2010), Chen Y (2013), Chen Y (2013)	8
CASP3	0	CDH1	4	imaging technique	Chen TC (2014)	1
G3BP1	4	BAG3	4	affinity chromatography technology	Jain S (2016)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
PIDD1	5	CRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tinel A (2004), Janssens S (2005), Logette E (2011), Jeong WJ (2012)	4
PI4KA	7	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	HSPB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Katsogiannou M (2014), Hein MY (2015)	4
MIP	1	CRYBB2	1	fluorescent resonance energy transfe	Liu BF (2008)	1
TP53	0	G3BP1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim MM (2007), Kim MM (2007), Kim MM (2007), Kim MM (2007)	4
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
G3BP1	4	HSPA4	3	affinity chromatography technology	Jain S (2016)	1
SNCA	0	BAX	3	imaging technique	Chen TC (2014)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
XIAP	0	HSPA4	3	affinity chromatography technology	Hegde R (2002)	1
CCDC85B	0	PIDD1	5	two hybrid	Rual JF (2005)	1
AVP	0	CRYAB	0	fluorescent resonance energy transfe, pull down	Santhoshkumar P (2006), Ghosh JG (2005)	2
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BAX	3	CASP7	1	biochemical	Chandra D (2004)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
CASP3	0	APP	1	imaging technique	Chen TC (2014)	1
HBA1	0	CRYAB	0	pull down	Clark TJ (2012)	1
HDAC1	4	CRYAB	0	affinity chromatography technology	Noh SJ (2008)	1
PSMD4	1	CRYAB	0	affinity chromatography technology	Weekes J (2003)	1
CRYGS	1	CRYAB	0	pull down	Kingsley CN (2013)	1
CRYAB	0	DDX20	4	two hybrid, affinity chromatography technology, affinity chromatography technology	den Engelsman J (2013), den Engelsman J (2013), Huttlin EL (2015)	3
HSPB2	1	567	0	two hybrid	Grose JH (2015)	1
CRYAB	0	NEFL	1	affinity chromatography technology	Huttlin EL (2015)	1
BAG3	4	PSMA3	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
BCL2L1	0	CASP9	6	affinity chromatography technology, imaging technique	Hu Y (1998), Chen TC (2014)	2
TP53	0	LYZ	0	affinity chromatography technology	Horikawa I (2014)	1
BAG3	4	HSPB8	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Taipale M (2014), Taipale M (2014), Yu H (2011), Hein MY (2015), Huttlin EL (2017)	6
CDH1	4	CC2D1A	1	bioid	Guo Z (2014)	1
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
CRYAB	0	CC2D1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
CASP2	1	PIDD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tinel A (2004), Janssens S (2005), Logette E (2011)	3
CRYAB	0	CCDC85C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPB8	0	HSPB2	1	two hybrid, affinity chromatography technology, two hybrid	Sun X (2004), Sun X (2004), Benndorf R (2001)	3
PRKN	1	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology	Choi P (2001), Choi P (2001), Kawahara K (2008), Hampe C (2006), Nemes Z (2009), Oluwatosin-Chigbu Y (2003), Yang Y (2003), Norris KL (2015)	8
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
BAG3	4	PRKAG3	1	affinity chromatography technology	Chen Y (2013)	1
FCF1	0	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
RBM24	0	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	HDAC1	4	affinity chromatography technology, biochemical	Yoon YM (2004), Yoon YM (2004)	2
CRYAB	0	CCND1	1	enzymatic study, pull down, enzymatic study	Lin DI (2006), Lin DI (2006), Barbash O (2009)	3
DDX20	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CRYAB	0	CDH1	4	affinity chromatography technology	Huang Z (2012)	1
LBH	0	CRYAB	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, imaging technique	Deng Y (2010), Deng Y (2010), Deng Y (2010), Deng Y (2010), Deng Y (2010)	5
INS	0	APP	1	pull down	Olah J (2011)	1
PRKN	1	CRYAB	0	affinity chromatography technology	Gong Y (2014)	1
GEMIN4	2	DDX20	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Carnegie GK (2003), Charroux B (2000), Charroux B (2000), Mourelatos Z (2002), Joshi P (2013), Joshi P (2013), Huttlin EL (2017)	7
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
HSPB1	2	CS	1	pull down	Rogalla T (1999)	1
PIDD1	5	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CRYAB	0	MRPL11	0	two hybrid	Rolland T (2014)	1
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
CRYAB	0	SEH1L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
ALB	1	GFAP	0	affinity chromatography technology	Zhou M (2004)	1
SOD1	0	CRYAB	0	pull down	Yerbury JJ (2013)	1
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
CRYAB	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology	Bellaye PS (2014), Bellaye PS (2014)	2
MIP	1	CRYGC	0	fluorescent resonance energy transfe	Liu BF (2008)	1
TMEM109	0	CRYAB	0	two hybrid, affinity chromatography technology	Yamashita A (2013), Yamashita A (2013)	2
CRYAB	0	TNPO2	10	two hybrid	Rolland T (2014)	1
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
BAX	3	XIAP	0	affinity chromatography technology	Gogada R (2011)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
SMAD4	9	HDAC1	4	affinity chromatography technology	Takeda M (2004)	1
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
NEFL	1	APP	1	imaging technique	Chen TC (2014)	1
BCL2	0	SOD1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Pasinelli P (2004), Pasinelli P (2004), Pasinelli P (2004), Pasinelli P (2004)	4
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
CRYAB	0	PRELID1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
ASB5	0	CRYAB	0	affinity chromatography technology	Andresen CA (2014)	1
CRYAB	0	DES	1	pull down	Ghosh JG (2007)	1
BMPR2	1	CRYAB	0	affinity chromatography technology	Hassel S (2004)	1
BAX	3	HSPA4	3	affinity chromatography technology	Guo F (2005)	1
CRYAB	0	HSPB2	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid	Sugiyama Y (2000), Sugiyama Y (2000), Fu L (2003), Fu L (2003), Delbecq SP (2012), Aquilina JA (2013), Grose JH (2015)	7
CRYAA	0	CRYAB	0	two hybrid, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe	Fu L (2002), Fu L (2002), Fu L (2002), Sreelakshmi Y (2005), Fu L (2003), Fu L (2003), Fu L (2003), Fu L (2003), Rao G (2008), Biswas A (2007), Wu M (2012), Wu M (2012), Fujii N (2008), Fujii N (2008), Sreelakshmi Y (2006), Delbecq SP (2012), Rolland T (2014), Validandi V (2011), Ramkumar S (2015), Tiwary E (2015), Tiwary E (2015)	21
CRYAB	0	NUDT16L1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAPPC2	0	TRAPPC6A	0	two hybrid, two hybrid, affinity chromatography technology	Scrivens PJ (2011), Scrivens PJ (2011), Huttlin EL (2017)	3
NEDD4L	3	NUDT16L1	4	pull down	Persaud A (2009)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CRADD	0	APP	1	pull down	Olah J (2011)	1
HSPB1	2	CRYBB2	1	two hybrid, affinity chromatography technology	Fu L (2002), Fu L (2002)	2
G3BP1	4	TNPO2	10	affinity chromatography technology	Jain S (2016)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
CRYAB	0	CRYBA1	0	pull down, imaging technique, two hybrid, fluorescent resonance energy transfe	Gupta R (2009), Gupta R (2009), Gupta R (2009), Gupta R (2009)	4
HSPB1	2	PSMA3	1	two hybrid	Katsogiannou M (2014)	1
SNCA	0	HSPB2	1	pull down	Bruinsma IB (2011)	1
TP53	0	PSMD4	1	affinity chromatography technology, pull down	Kulikov R (2010), Sparks A (2014)	2
BAG3	4	CASP3	0	biochemical	Wan C (2015)	1
PRKN	1	PSMA3	1	affinity chromatography technology	Sarraf SA (2013)	1
CASP12	1	CASP9	6	enzymatic study	Morishima N (2002)	1
MRPL11	0	APP	1	pull down	Olah J (2011)	1
CASP6	0	APP	1	imaging technique	Chen TC (2014)	1
FOXD4	1	CRYAB	0	affinity chromatography technology	Li X (2015)	1
GPBP1	2	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPB1	2	CRYAA	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Fu L (2002), Fu L (2002), Fu L (2003), Fu L (2003)	4
TRIM33	4	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Bellaye PS (2014), Bellaye PS (2014)	2
PSMD4	1	PRKN	1	pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Safadi SS (2010), Uchiki T (2009), Sakata E (2003), Safadi SS (2011), Um JW (2010), Um JW (2010), Kim HT (2012), Beasley SA (2012), Sarraf SA (2013), Sarraf SA (2013)	10
HSPB2	1	TTN	102	two hybrid	Grose JH (2015)	1
TRAPPC2	0	TRAPPC9	6	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Scrivens PJ (2011), Scrivens PJ (2011), Scrivens PJ (2011), Huttlin EL (2017)	4
CRYAB	0	GOPC	5	affinity chromatography technology	Huttlin EL (2015)	1
CASP3	0	BCL2	0	enzymatic study	Liang Y (2002)	1
PSMD4	1	PSMA3	1	biochemical	Wan C (2015)	1
VEGFA	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Park JH (2008), Kishor A (2013)	2
SOD1	0	DES	1	affinity chromatography technology	Malty RH (2017)	1
PSMD4	1	HSPA4	3	affinity chromatography technology	Andersen KM (2009)	1
BAG3	4	BCL2	0	affinity chromatography technology	Boiani M (2013)	1
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
PSMA3	1	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
ALB	1	TTN	102	affinity chromatography technology	Zhou M (2004)	1
CASP3	0	CTNNB1	30	imaging technique	Chen TC (2014)	1
CRYAB	0	FBXO21	2	affinity chromatography technology	Huttlin EL (2015)	1
BCL2L1	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hollville E (2014), Hollville E (2014), Gong Y (2017), Gong Y (2017), Gong Y (2017)	5
BAX	3	CASP9	6	biochemical	Chandra D (2004)	1
CRYAB	0	FGF2	1	unspecified method	Ghosh JG (2007)	1
GMCL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	CCND1	1	affinity chromatography technology, enzymatic study	Gong Y (2014), Gong Y (2014)	2
CRYAB	0	HNRNPUL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OAZ3	2	CRYAB	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4L	3	PSMD4	1	enzymatic study	Isasa M (2010)	1
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3
CRYAB	0	CRYAB	0	two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, x-ray crystallography, x-ray crystallography, x-ray crystallography, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, x-ray crystallography, x-ray crystallography	Sugiyama Y (2000), Fu L (2002), Liu L (2006), Fu L (2003), Fu L (2003), Michiel M (2009), Santhoshkumar P (2006), Murugesan R (2008), Jehle S (2010), Bagneris C (2009), Braun N (2011), Braun N (2011), Fujii N (2008), DeGrado-Warren J (2008), Rolland T (2014), Yamamoto S (2014), Rajagopal P (2015), Mainz A (2015)	18
PRKN	1	NEFL	1	affinity chromatography technology	Zanon A (2013)	1
CASP2	1	CRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, two hybrid	Tinel A (2004), Droin N (2000), Droin N (2000), Duan H (1997), Duan H (1997), Duan H (1997), Jeong WJ (2012), Rolland T (2014)	8
ALB	1	SCN5A	9	affinity chromatography technology	Zhou M (2004)	1
SNCA	0	HSPB1	2	affinity chromatography technology, pull down	Nemes Z (2009), Bruinsma IB (2011)	2
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CRYAB	0	LYZ	0	x-ray crystallography	Mainz A (2015)	1
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
CRYAB	0	CDC23	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRYAB	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
MIP	1	CRYAA	0	fluorescent resonance energy transfe	Liu BF (2008)	1
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
CRYAB	0	APP	1	pull down, pull down, unspecified method, x-ray crystallography, pull down	Raman B (2005), Narayanan S (2006), Shammas SL (2011), Mainz A (2015), Narayan P (2012)	5
CRYGC	0	HSPB2	1	two hybrid	Fu L (2003)	1
BCL2L1	0	BAX	3	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Strobel T (1998), Zhang H (2002), Gillissen B (2003), Ren H (2011), Ren H (2011), Chinnaiyan AM (1997), Diaz JL (1997), Wang X (2009), Wang X (2009), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Tong J (2017), Huttlin EL (2017), Kim EM (2014)	17
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1
CRYAB	0	FAM83D	1	affinity chromatography technology	Huttlin EL (2015)	1
CRYGC	0	HSPB1	2	two hybrid	Fu L (2003)	1