PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2I	0	7515	0	enzymatic study	Gocke CB (2005)	1
POLB	0	APTX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
CEBPA	0	XRCC5	5	affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Yin H (2006), Yin H (2006)	3
CDKN1A	1	HDAC1	4	pull down, affinity chromatography technology, pull down, imaging technique	Li Z (2010), Li Z (2010), Garcia-Wilson E (2005), Chen TC (2014)	4
H2AFY	1	TOP1	1	affinity chromatography technology	Ouararhni K (2006)	1
HIST1H3E	0	PCNA	0	biochemical	Campos EI (2015)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
SIRT1	3	WRN	6	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Law IK (2009), Law IK (2009), Li K (2008), Li K (2008), Li K (2008), Li K (2008)	6
RELA	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Zhong H (2002), Zhong H (2002), Zhong H (2002), Zhong H (2002), Ashburner BP (2001), Ashburner BP (2001), OShea JM (2010), OShea JM (2010), Liu Y (2006), Cao W (2006), Hu J (2004), Hu J (2004), Sun JM (2007), Deckmann K (2012)	15
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
EP300	36	POLB	0	affinity chromatography technology, pull down, pull down, enzymatic study	Hasan S (2002), Hasan S (2002), Hasan S (2002), Hasan S (2002)	4
CHFR	5	HDAC2	1	affinity chromatography technology, pull down	Oh YM (2009), Oh YM (2009)	2
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
H2AFX	1	HIST1H1C	2	affinity chromatography technology	Huttlin EL (2017)	1
CEBPA	0	KLF5	4	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Fujiu K (2011), Fujiu K (2011), Fujiu K (2011), Fujiu K (2011)	4
BRCA1	7	GTF2F1	0	biochemical	Scully R (1997)	1
HIST1H3E	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology, biochemical	Drane P (2010), Shuaib M (2010), Campos EI (2015)	3
TP53	0	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Al Rashid ST (2005), Al Rashid ST (2005)	2
BRCA1	7	H2AFY	1	imaging technique	Ganesan S (2002)	1
PARP1	3	APLF	3	pull down, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Kanno S (2007), Eustermann S (2010), Ahel I (2008), Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	7
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
PARP1	3	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Sand-Dejmek J (2011), Wu T (2013)	11
H3F3A	1	XRCC5	5	affinity chromatography technology	Drane P (2010)	1
NFKB1	2	HDAC2	1	affinity chromatography technology	Sun JM (2007)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
ERG	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Brenner JC (2011), Brenner JC (2011), Wang S (2014), Wang S (2014)	4
BRCA1	7	HDAC2	1	pull down, affinity chromatography technology, genetic interference	Yarden RI (1999), Chang S (2011), Shen JP (2017)	3
CASP3	0	SP1	0	enzymatic study	Rickers A (1999)	1
PARP1	3	UBE2I	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study, pull down, enzymatic study	Masson M (1997), Masson M (1997), Masson M (1997), Zilio N (2013), Matafora V (2009), Zilio N (2013), Gocke CB (2005)	7
CHD1L	5	RPA2	0	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009)	2
XRCC5	5	TOP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sand-Dejmek J (2011), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	5
TOP1	1	CDK8	1	unspecified method	Trzcinska AM (2002)	1
HIST1H3E	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, biochemical	Drane P (2010), Shuaib M (2010), Campos EI (2015)	3
CHFR	5	PCNA	0	affinity chromatography technology	Oh YM (2009)	1
CASP7	1	SP1	0	enzymatic study	Rickers A (1999)	1
TP53	0	ERCC6	6	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wang XW (1995), Yu A (2000), Yu A (2000), Latini P (2011), Latini P (2011)	5
BRCA1	7	RELA	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Benezra M (2003), Benezra M (2003), Benezra M (2003), Volcic M (2012)	4
HDAC1	4	POU2F1	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Wang P (2009), Wang P (2009), Wang P (2009)	3
HIST1H2BA	0	PARP1	3	pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2010), Huttlin EL (2015), Huttlin EL (2017)	3
H3F3A	1	XRCC6	3	affinity chromatography technology	Drane P (2010)	1
PARP1	3	PIAS4	5	affinity chromatography technology, pull down, pull down, enzymatic study	Martin N (2009), Martin N (2009), Martin N (2009), Ryu H (2010)	4
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
SP1	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won J (2002), Zhang Y (2002), Sun JM (2002), Glasspool RM (2005), Duan H (2005), Sekhavat A (2007), Itoh Y (2007), Marshall GM (2010), Tsai PF (2011), Schnur N (2007)	10
BRCA1	7	H2AFX	1	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, enzymatic study, affinity chromatography technology, imaging technique	Mallery DL (2002), Paull TT (2000), Ray A (2009), Tsai WB (2008), Mok MT (2010), Nelson AC (2010), Chen A (2002), Dutta D (2015), Dutta D (2015)	9
RPA2	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shao RG (1999), Shao RG (1999), Marechal A (2014), Wan C (2015)	4
POLB	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APLF	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
EP300	36	KLF8	0	affinity chromatography technology	Urvalek AM (2010)	1
CDKN1A	1	FOXO1	2	imaging technique	Chen TC (2014)	1
HDAC1	4	HES1	0	affinity chromatography technology	Shen Q (2005)	1
HES1	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kannan S (2011), Kannan S (2011), Kannan S (2011)	3
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
XRCC5	5	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matheos D (2002), Ohta S (2002), Balajee AS (2001)	3
RNF146	4	CHD1L	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
POU2F1	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schild-Poulter C (2001), Matheos D (2002), Schaffer A (2003)	3
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
SP1	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zaniolo K (2007), Zaniolo K (2007), Zaniolo K (2007)	3
CASP3	0	PARP1	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nicholson DW (1995), Lueschen S (1998), Walsh JG (2008), Boucher D (2012), Luo S (2010), Betin VM (2009)	6
SP1	0	RELA	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuang PP (2002), Sif S (1994), Sif S (1994), Kao YS (2008), Kao YS (2008), Benjamin JT (2010), Beauchef G (2012), Xu Y (2008)	8
HIPK2	0	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	4
BUB1B	0	HDAC1	4	affinity chromatography technology, biochemical	Yoon YM (2004), Yoon YM (2004)	2
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
APLF	3	H2AFY	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
WRN	6	XRCC5	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar P (2002), Karmakar P (2002), Li B (2000), Cooper MP (2000), Cooper MP (2000), Cooper MP (2000), Orren DK (2001), Li B (2004), Li B (2004), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Partridge JJ (2003), Partridge JJ (2003), Hein MY (2015)	14
PARP1	3	MAFG	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu T (2013), Wu T (2013), Wu T (2013)	3
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
H2AFX	1	CTCF	15	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	HDAC2	1	pull down, affinity chromatography technology	Li X (2014), Huttlin EL (2017)	2
ERG	1	TOP1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
BRCA1	7	POU2F1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fan W (2002), Hosey AM (2007), Hosey AM (2007), Harte MT (2010)	4
ERCC6	6	PARP1	3	pull down, affinity chromatography technology, enzymatic study	Thorslund T (2005), Thorslund T (2005), Thorslund T (2005)	3
RNF146	4	PARP1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011), Kang HC (2011), Kang HC (2011), Huttlin EL (2015), Huttlin EL (2017)	6
H3F3A	1	EP300	36	affinity chromatography technology	Zhang X (2017)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
H3F3A	1	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Heo K (2007), Messner S (2010), Drane P (2010), Drane P (2010), Bonfiglio JJ (2017)	5
TP53	0	TOP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Gobert C (1999), Mao Y (2002), Restle A (2008)	3
EP300	36	FOXO1	2	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Brent MM (2008), Perrot V (2005), Perrot V (2005), Perrot V (2005), Perrot V (2005), Pramanik KC (2014), Pramanik KC (2014), Mahmud DL (2002), Li X (2015)	9
UBE2I	0	CHFR	5	enzymatic study	Kwon YE (2013)	1
RNF146	4	HIST1H1C	2	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
7515	0	TP53	0	affinity chromatography technology	Gueven N (2004)	1
PARP1	3	GTF2F1	0	affinity chromatography technology, pull down, pull down	Hassa PO (2005), Hassa PO (2005), Hassa PO (2005)	3
RNF146	4	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Kang HC (2011), Kang HC (2011)	2
KLF5	4	TP53	0	affinity chromatography technology, affinity chromatography technology	Zhu N (2006), Zhu N (2006)	2
RELA	1	PARP1	3	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hassa PO (2001), Hassa PO (2001), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008)	6
IKBKG	0	PIAS4	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mabb AM (2006), Mabb AM (2006), Wu ZH (2008), Mohanty S (2014), Wu Z (2015)	5
KLF5	4	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyamoto S (2003), Matsumura T (2005), Guo P (2009), Guo P (2009), Nagai R (2005)	5
NFKB1	2	IKBKG	0	affinity chromatography technology, pull down	Bouwmeester T (2004), Smolle M (2004)	2
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
CDKN1A	1	HDAC2	1	pull down	Garcia-Wilson E (2005)	1
RPA2	0	LIG3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Huttlin EL (2015), Huttlin EL (2017)	3
SIRT1	3	RELA	1	affinity chromatography technology	Yang SR (2007)	1
XRCC6	3	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
KLF5	4	HDAC2	1	affinity chromatography technology, imaging technique	Zheng B (2011), Zheng B (2011)	2
APTX	3	TP53	0	affinity chromatography technology, pull down	Gueven N (2004), Gueven N (2004)	2
PARP1	3	CDK8	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Pavri R (2005)	4
APTX	3	LIG3	6	affinity chromatography technology	Luo H (2004)	1
PARP1	3	PARP1	3	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Hassa PO (2005), Lonskaya I (2005), Langelier MF (2010), Idogawa M (2007), Li B (2004), Ali AA (2012), Ali AA (2012), Lai YS (2012), Lai YS (2012), Kim BK (2014), Meyer-Ficca ML (2015), Gibbs-Seymour I (2016), Bonfiglio JJ (2017), Brodie SA (2015)	14
HIST1H2BA	0	CHD1L	5	affinity chromatography technology	Huttlin EL (2015)	1
PCNA	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ohta S (2002), Ohta S (2002), Balajee AS (2001), Nicolae CM (2014)	4
RPA2	0	7515	0	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Huttlin EL (2017)	2
BRCA1	7	PIAS4	5	imaging technique, enzymatic study, imaging technique	Galanty Y (2009), Morris JR (2009), Morris JR (2009)	3
HIST1H2BA	0	APLF	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
PIAS4	5	HDAC2	1	pull down	Gross M (2004)	1
BRCA1	7	CDK8	1	biochemical	Scully R (1997)	1
CHD1L	5	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Huttlin EL (2017)	2
HDAC1	4	ERCC6	6	affinity chromatography technology	Hein MY (2015)	1
LIG3	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Huttlin EL (2017)	3
HIST1H2BA	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology	Li X (2014), Huttlin EL (2015), Huttlin EL (2017)	3
RNF146	4	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHD1L	5	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Brockschmidt A (2011), Kulkarni A (2013), Huttlin EL (2017)	5
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
PARP1	3	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Pozo FM (2011), Sekimoto T (2010)	6
HPF1	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Gibbs-Seymour I (2016), Bonfiglio JJ (2017)	4
SIRT1	3	PARP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Rajamohan SB (2009), Rajamohan SB (2009), Rajamohan SB (2009), Rajamohan SB (2009)	4
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
CDKN1A	1	PARP1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010)	4
HDAC1	4	H3F3A	1	affinity chromatography technology	Hein MY (2015)	1
HIST1H3E	0	TOP1	1	affinity chromatography technology	Drane P (2010)	1
HIST1H2BA	0	7515	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
GTF2F1	0	CDK8	1	affinity chromatography technology	Cujec TP (1997)	1
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
PARP1	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hassa PO (2005), Hassa PO (2005), Hang CT (2010), Rajamohan SB (2009)	4
EP300	36	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hasan S (2001), Hasan S (2001), Hasan S (2001), Hong R (2003), Hong R (2003), Cazzalini O (2008), Cazzalini O (2008), Naryzhny SN (2004), Cazzalini O (2014), Cazzalini O (2014)	10
RPA2	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Huttlin EL (2015), Huttlin EL (2017)	3
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
XRCC6	3	7515	0	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
MACROD1	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Wu Z (2015), Wu Z (2015)	2
H2AFY	1	XRCC5	5	affinity chromatography technology	Ouararhni K (2006)	1
CHD1L	5	7515	0	affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Huttlin EL (2017)	2
ERG	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Brenner JC (2011), Brenner JC (2011)	2
APTX	3	7515	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Date H (2004), Date H (2004), Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004), Lim J (2006), Luo H (2004), Luo H (2004), Luo H (2004), Luo H (2004), Hein MY (2015)	13
FOXO1	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kitamura YI (2005), Bastien-Dionne PO (2011), Yang Y (2005), Yang Y (2005)	4
CHD1L	5	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009), Ahel D (2009), Kulkarni A (2013), Huttlin EL (2017)	5
HIST1H3E	0	HIST1H1C	2	affinity chromatography technology	Campos EI (2015)	1
TP53	0	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Borellini F (1993), Jin W (2008), Dhar SK (2006), Lagger G (2003), Lagger G (2003), Lagger G (2003), Lagger G (2003), Sengupta S (2005), Sengupta S (2005), Lin RK (2010), Kim HA (2011), Sawaya BE (1998), St Clair S (2004), Innocente SA (2005), Innocente SA (2005), Ohlsson C (1998), Kong X (2013), Bocangel D (2009), Bocangel D (2009)	19
TOP1	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	4
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
HIST1H2BA	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLF5	4	HDAC1	4	affinity chromatography technology, pull down, pull down	Matsumura T (2005), Matsumura T (2005), Matsumura T (2005)	3
UBE2I	0	XRCC5	5	enzymatic study	Gocke CB (2005)	1
CDKN1A	1	IKBKG	0	two hybrid	Journo C (2009)	1
PARP1	3	POU2F1	5	far western blotting, pull down, two hybrid	Nie J (1998), Nie J (1998), Nie J (1998)	3
CEBPA	0	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Yin H (2006), Yin H (2006), Yin H (2006)	3
PARP1	3	POLB	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Huttlin EL (2015), Huttlin EL (2017)	5
XRCC5	5	APLF	3	pull down, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Huttlin EL (2015), Huttlin EL (2017)	3
POLB	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Masaoka A (2013), Masaoka A (2013), Masaoka A (2013), Masaoka A (2013), Masaoka A (2013)	5
XRCC5	5	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wei L (2008), Wei L (2008), Jiang G (2013), Jiang G (2013), Jiang G (2013), Ertych N (2016)	6
RNF146	4	XRCC6	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kang HC (2011), Kang HC (2011), Kang HC (2011)	3
H2AFX	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Yang X (2010), Yang X (2010), Huttlin EL (2017)	8
CHD1L	5	APLF	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahel D (2009), Kulkarni A (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CASP7	1	PARP1	3	enzymatic study, enzymatic study, enzymatic study	Lueschen S (1998), Walsh JG (2008), Boucher D (2012)	3
WRN	6	H2AFX	1	affinity chromatography technology, pull down	Cheng WH (2005), Cheng WH (2005)	2
PARP1	3	BUB1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fang Y (2006), Fang Y (2006), Fang Y (2006)	3
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
HIST1H2BA	0	H2AFY	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIPK2	0	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Choi JR (2016), Choi JR (2016), Choi JR (2016)	3
CDKN1A	1	PCNA	0	two hybrid, pull down, pull down, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Frouin I (2003), Watanabe H (1998), Fotedar R (1996), Jonsson ZO (1998), Gulbis JM (1996), Touitou R (2001), Yu P (2001), Yu P (2001), Chen X (2007), Chen X (2007), Wang SC (2006), Carujo S (2006), Garcia-Wilson E (2005), Howlett NG (2009), Jin Y (2008), Lee JY (2009), Ando T (2001), Ando T (2001), Takasaki Y (2001), Logette E (2011), Mistafa O (2010), Mistafa O (2010), Bruning JB (2004), Punchihewa C (2012), Mattock H (2001), Waga S (1994), Waga S (1994), Poon RY (1996), Zhang Y (1999), Warbrick E (1995), Warbrick E (1995), Poon RY (1998), Poon RY (1998), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Rizzardi LF (2014), Trombetta A (2013), Trombetta A (2013), Kim DH (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Coleman KE (2015), Huttlin EL (2017), Roessig L (2001), Roessig L (2001)	48
NFKB1	2	KLF5	4	affinity chromatography technology, affinity chromatography technology	Aizawa K (2004), Nagai R (2005)	2
APLF	3	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLF8	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Lu H (2011), Lu H (2011), Lu H (2011), Lu H (2011), Lu H (2011)	5
CEBPA	0	HDAC1	4	affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology	Duan H (2005), Matsunaga N (2012), Matsunaga N (2012), Girard N (2013)	4
CHFR	5	RELA	1	affinity chromatography technology, affinity chromatography technology	Kashima L (2009), Kashima L (2009)	2
HDAC1	4	NFKB1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, imaging technique	Zhong H (2002), Zhong H (2002), Zhong H (2002), Viatour P (2003), Williams SA (2006), Williams SA (2006), Sun JM (2007), Chen TC (2014)	8
POLB	0	7515	0	two hybrid, pull down, pull down, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2004), Fan J (2004), Kubota Y (1996), Kubota Y (1996), Bhattacharyya N (2001), Bhattacharyya N (2001), Luo H (2004), Huttlin EL (2015), Hein MY (2015), Fang Q (2014), Fang Q (2014), Huttlin EL (2017)	12
RPA2	0	WRN	6	affinity chromatography technology	Marechal A (2014)	1
H2AFX	1	H2AFY	1	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ju BG (2006), Galande S (1999), Galande S (1999), Galande S (1999), Idogawa M (2007), Li B (2004), Li B (2004), Yin H (2006), Yin H (2006), Wu T (2013), Huttlin EL (2017)	11
RELA	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kiernan R (2003), Yu Z (2002), Yu Z (2002), Ito K (2001), Ito K (2000), Sun JM (2007), Adenuga D (2010), Wang H (2010), Chen TC (2014)	9
CHD1L	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Gottschalk AJ (2009), Ahel D (2009)	2
PCNA	0	7515	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology	Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Ogi T (2010)	6
MACROD1	0	LIG3	6	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
UBE2I	0	KLF5	4	enzymatic study	Oishi Y (2008)	1
UBE2I	0	HIPK2	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, enzymatic study	Lee BH (2003), Bandyopadhyay S (2010), Sung KS (2005), Sung KS (2005), Hofmann TG (2005), Sung KS (2005)	6
ZNF423	14	PARP1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ku MC (2003), Ku MC (2003), Chaki M (2012), Chaki M (2012)	4
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
H2AFX	1	LIG3	6	affinity chromatography technology	Huttlin EL (2017)	1
TOP1	1	PARP1	3	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, biochemical	Czubaty A (2005), Yung TM (2004), Yung TM (2004), Yung TM (2004), Yung TM (2004)	5
APTX	3	PARP1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004)	5
APLF	3	7515	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
TOP1	1	UBE2I	0	two hybrid, pull down, pull down	Mao Y (2000), Mao Y (2000), Mao Y (2000)	3
H2AFY	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ouararhni K (2006), Chakravarthy S (2005), Chakravarthy S (2005), Wu C (2007), Wu C (2007)	5
CHFR	5	SIRT1	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kim M (2016), Kim M (2016), Kim M (2016), Kim M (2016)	4
EP300	36	XRCC6	3	enzymatic study	Cohen HY (2004)	1
PCNA	0	RPA2	0	affinity chromatography technology	Takasaki Y (2001)	1
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
HPF1	1	H2AFY	1	affinity chromatography technology, affinity chromatography technology	Gibbs-Seymour I (2016), Gibbs-Seymour I (2016)	2
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
IKBKG	0	RELA	1	enzymatic study	Dan HC (2008)	1
HDAC2	1	BUB1B	0	affinity chromatography technology, affinity chromatography technology	Park I (2017), Park I (2017)	2
BRCA1	7	TOP1	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Shen JP (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	7
POLB	0	APLF	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
HDAC2	1	H2AFY	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chakravarthy S (2005), Wu C (2007), Wu C (2007)	3
RNF146	4	7515	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Kang HC (2011), Kang HC (2011), Kang HC (2011)	3
PARP1	3	NFKB1	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Hassa PO (2005), Hassa PO (2005), Amiri KI (2006), Amiri KI (2006), Amiri KI (2006)	5
XRCC5	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Zhang Z (2017), Zhang Z (2017)	2
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
H3F3A	1	TOP1	1	affinity chromatography technology	Drane P (2010)	1
HES1	0	SIRT1	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Takata T (2003), Takata T (2003), Takata T (2003), Takata T (2003)	4
CDKN1A	1	CEBPA	0	pull down, two hybrid	Timchenko NA (1997), Timchenko NA (1997)	2
CHFR	5	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Oh YM (2009), Oh YM (2009), Oh YM (2009), Oh YM (2009), Oh YM (2009)	5
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
CEBPA	0	XRCC6	3	pull down, affinity chromatography technology	Yin H (2006), Yin H (2006)	2
PCNA	0	POLB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Naryzhny SN (2004), Zhang Z (2014), Zhang Z (2014), Zhang Z (2014)	4
MACROD1	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Wu Z (2015), Wu Z (2015)	2
CHFR	5	PARP1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kashima L (2012), Kashima L (2012), Ahel I (2008), Oh YM (2009), Liu C (2013), Brodie SA (2015), Brodie SA (2015)	7
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
PCNA	0	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Milutinovic S (2002), Milutinovic S (2002), Naryzhny SN (2004)	3
PCNA	0	TOP1	1	affinity chromatography technology	Takasaki Y (2001)	1
TOP1	1	HIST1H1C	2	affinity chromatography technology	Czubaty A (2005)	1
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
TP53	0	CDK8	1	pull down	Gu W (1999)	1
SIRT1	3	HDAC2	1	affinity chromatography technology	Law IK (2009)	1
PARP1	3	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Huttlin EL (2017)	5
WRN	6	XRCC6	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karmakar P (2002), Karmakar P (2002), Li B (2000), Cooper MP (2000), Cooper MP (2000), Cooper MP (2000), Li B (2004), Li B (2004), Hein MY (2015), Huttlin EL (2017)	10
PARP1	3	HDAC2	1	affinity chromatography technology, pull down, affinity chromatography technology	Hassa PO (2005), Hassa PO (2005), Hang CT (2010)	3
HIST1H3E	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Drane P (2010), Drane P (2010), Shuaib M (2010)	3
KLF5	4	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Suzuki T (2007), Suzuki T (2007), Suzuki T (2007)	3
IKBKG	0	MACROD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015), Wu Z (2015)	5
WRN	6	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Li B (2004), Li B (2004), Li B (2004)	3
WRN	6	TP53	0	affinity chromatography technology, pull down, pull down	Yang Q (2002), Yang Q (2002), Brosh RM (2001)	3
POU2F1	5	XRCC6	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Schild-Poulter C (2001), Schild-Poulter C (2007), Schaffer A (2003), Schaffer A (2003)	4
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
ERCC6	6	BRCA1	7	affinity chromatography technology, enzymatic study	Wei L (2011), Wei L (2011)	2
HPF1	1	H3F3A	1	pull down	Bonfiglio JJ (2017)	1
H3F3A	1	H2AFY	1	imaging technique	Soldi M (2013)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
HIST1H3E	0	HDAC1	4	affinity chromatography technology	Campos EI (2015)	1
SP1	0	POU2F1	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Stroem AC (1996), Stroem AC (1996), Gunther M (2000), Lim K (2009), Lim K (2009)	5
ZNF423	14	BRCA1	7	two hybrid	Hill SJ (2014)	1
SP1	0	NFKB1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sif S (1994), Dhar SK (2006), Liu S (2008)	3
ERCC6	6	PCNA	0	affinity chromatography technology	Anindya R (2010)	1
SP1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Padova M (2003), Singh J (2002), Zhang Y (2002), Sun JM (2002), Gao J (2009), Shon JK (2009), Mottet D (2009), Goto T (2006), Hung JJ (2006), Lagger G (2003), Choi HS (2002), Choi HS (2002), Kang JE (2005), Kang JE (2005), Kang JE (2005), Gan Y (2005), Gan Y (2005), Duan H (2005), Varshochi R (2005), Varshochi R (2005), Plaisance V (2005), Walker GE (2001), Walker GE (2001), Ammanamanchi S (2004), Doetzlhofer A (1999), Sekhavat A (2007), Liu T (2007), Enya K (2008), Liu S (2010), Leclerc GJ (2010), Leclerc GJ (2010), Wong CY (2011), Schnur N (2007)	33
BRCA1	7	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
CTCF	15	PARP1	3	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Farrar D (2010), Farrar D (2010), Farrar D (2010), Yusufzai TM (2004), Witcher M (2009), Witcher M (2009)	6
H2AFY	1	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down	Ouararhni K (2006), Nusinow DA (2007), Nusinow DA (2007), Nusinow DA (2007), Chen H (2014), Sarma K (2014), Sarma K (2014), Forst AH (2013)	8
RELA	1	POU2F1	5	pull down, affinity chromatography technology	van Heel DA (2002), van Heel DA (2002)	2
NCAPD2	5	PARP1	3	far western blotting, affinity chromatography technology, affinity chromatography technology	Heale JT (2006), Heale JT (2006), Heale JT (2006)	3
APLF	3	TOP1	1	affinity chromatography technology	Huttlin EL (2015)	1
CASP3	0	CDKN1A	1	enzymatic study, enzymatic study, enzymatic study, imaging technique	Levkau B (1998), Park JA (1998), Zhang Y (1999), Chen TC (2014)	4
LIG3	6	XRCC5	5	affinity chromatography technology, pull down	Leppard JB (2003), Leppard JB (2003)	2
POLB	0	WRN	6	far western blotting	Jiao R (2007)	1
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
HIST1H1C	2	PARP1	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Kim K (2008), Kim K (2008), Kim K (2008), Bonfiglio JJ (2017)	4
PARP1	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down	Wu Z (2015), Wu Z (2015), Wu Z (2015)	3
MACROD1	0	H2AFX	1	affinity chromatography technology	Huttlin EL (2017)	1
PARP1	3	FOXO1	2	affinity chromatography technology, affinity chromatography technology, pull down	Sakamaki J (2009), Sakamaki J (2009), Sakamaki J (2009)	3
SIRT1	3	UBE2I	0	enzymatic study	Hsieh YL (2013)	1
CEBPA	0	HDAC2	1	affinity chromatography technology	Duan H (2005)	1
ERG	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Brenner JC (2011), Brenner JC (2011)	2