PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K6	2	MAPK14	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfe	Sanz-Moreno V (2003), Raingeaud J (1996), Stein B (1996), Chen Z (2001), Casar B (2007), Xia Y (1998), ter Haar E (2007), Ivanov AA (2017)	8
RPS6KA5	2	MAPK1	1	genetic interference	Deak M (1998)	1
MAPK14	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Zhang S (2006)	2
RB1	2	KAT2B	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nguyen DX (2004), Nguyen DX (2004), Nguyen DX (2004), Ianari A (2009)	4
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
TP53	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Li X (2015)	4
MAPK14	0	FLYWCH2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP7	3	DUSP9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP16	0	MAPK1	1	affinity chromatography technology	Masuda K (2001)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
PTPN7	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
BTRC	1	CDC25B	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uchida S (2011), Uchida S (2011), Kanemori Y (2005), Kim TY (2014), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	10
TP53	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK14	0	CSNK1G2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW8	2	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008)	13
MAPK11	1	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
MAPK14	0	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
TP53	0	CSNK2B	5	protein complementation assay	Srivastav RK (2011)	1
MAPK14	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Wang J (2013)	2
CDC25C	0	MAPK1	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
MKNK1	0	MAPK1	1	pull down, two hybrid, pull down	Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	3
MAPK14	0	KAT2B	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	4
MAPK14	0	TSC1	4	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Pilot-Storck F (2010), Pilot-Storck F (2010), Ivanov AA (2017)	3
MAPK14	0	RB1	2	enzymatic study, affinity chromatography technology	Delston RB (2011), Li H (2001)	2
MAPK11	1	MAPKAPK3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
AKT1	1	ZFP36L1	1	enzymatic study	Benjamin D (2006)	1
CSNK2A1	15	CDC25B	4	enzymatic study, pull down, affinity chromatography technology	Theis-Febvre N (2003), Theis-Febvre N (2003), Theis-Febvre N (2003)	3
KAT2B	2	CDT1	2	enzymatic study	Glozak MA (2009)	1
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
MKNK2	1	MAPK1	1	affinity chromatography technology, pull down, two hybrid, pull down	Scheper GC (2003), Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	4
MAPK14	0	HDAC3	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	3
CUL7	4	SQSTM1	0	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	MKNK2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Bandyopadhyay S (2010), Varjosalo M (2013), Huttlin EL (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	6
MAPK3	4	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
OBSL1	9	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
KIF22	1	USP47	4	affinity chromatography technology	Huttlin EL (2017)	1
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
MAPKAPK3	0	5616	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sudo T (2000), Sudo T (2000), Kawai K (2008), Kawai K (2008)	4
OBSL1	9	CSNK2B	5	affinity chromatography technology	Hanson D (2014)	1
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
KAT2B	2	MEF2D	5	affinity chromatography technology	Gregoire S (2007)	1
MKNK2	1	RICTOR	4	affinity chromatography technology	Hein MY (2015)	1
ZFP36L1	1	MAPK14	0	two hybrid, affinity chromatography technology, enzymatic study	Rual JF (2005), Rual JF (2005), Benjamin D (2006)	3
TP53	0	NFKBIA	0	affinity chromatography technology, two hybrid	Chang NS (2002), Chang NS (2002)	2
MAPKAPK3	0	MAPK14	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Tanoue T (2001), Tanoue T (2001), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Vogl T (2004), Huttlin EL (2017)	10
HDAC3	5	AKT1	1	affinity chromatography technology	Zampetaki A (2010)	1
MAPK14	0	MKNK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	7
CUL7	4	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
MAPK14	0	AMMECR1L	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDT1	2	MAPK14	0	affinity chromatography technology, enzymatic study	Chandrasekaran S (2011), Chandrasekaran S (2011)	2
MAP2K3	1	MAPK3	4	pull down	Zheng CF (1993)	1
RB1	2	ATF2	1	pull down, affinity chromatography technology, affinity chromatography technology	Kim SJ (1992), Li H (2001), Li H (2001)	3
DUSP4	1	MAP2K6	2	affinity chromatography technology	Li X (2016)	1
EP300	36	RECQL4	5	affinity chromatography technology, enzymatic study, pull down	Dietschy T (2009), Dietschy T (2009), Dietschy T (2009)	3
MAPK14	0	HOXB6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	YY1AP1	0	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
DUSP1	1	IKBKB	1	affinity chromatography technology	Lallena MJ (1999)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
MAP2K6	2	MAPKAPK2	1	enzymatic study	ter Haar E (2007)	1
MYLK3	3	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
IQGAP1	1	AKT1	1	affinity chromatography technology	Tekletsadik YK (2012)	1
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
CSNK2B	5	MAPK14	0	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
MAPK14	0	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Varjosalo M (2013), Huttlin EL (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Camps M (1998)	6
ARHGAP9	2	MAPK14	0	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4
MAP2K3	1	MAP2K6	2	genetic interference, affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Huber TB (2001), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	5
CDKN1A	1	CIZ1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Mitsui K (1999), Mitsui K (1999), Mitsui K (1999)	3
CDC25C	0	MAPK3	4	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
MAPK3	4	MKNK1	0	enzymatic study	Fukunaga R (1997)	1
AKT1	1	MAPK14	0	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Rane MJ (2001), Rane MJ (2001), Hartman AD (2006), Rane MJ (2001), Rane MJ (2001), Ivanov AA (2017)	6
MAPK11	1	HDAC3	5	two hybrid, far western blotting, pull down	Mahlknecht U (2004), Mahlknecht U (2004), Mahlknecht U (2004)	3
SQSTM1	0	MBP	0	pull down	Pridgeon JW (2004)	1
MAPK14	0	HOXC9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC3	5	NFKBIA	0	affinity chromatography technology	Gao Z (2006)	1
SMAD7	1	MAP2K3	1	affinity chromatography technology	Edlund S (2003)	1
PTPRR	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
DUSP9	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, pull down	St-Denis N (2016), Li X (2016), Camps M (1998)	3
NFKBIA	0	FBXW8	2	affinity chromatography technology	Keutgens A (2010)	1
SMAD7	1	KAT2B	2	affinity chromatography technology	Monteleone G (2005)	1
MAP2K3	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K6	2	MAP2K4	3	enzymatic study	Takekawa M (2005)	1
BTRC	1	USP47	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Peschiaroli A (2010), Kim TY (2014), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	6
MAPK14	0	HOXA10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MEF2D	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Youn HD (2000), Youn HD (2000)	2
CUL7	4	IQGAP1	1	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	MYLK3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK11	1	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), St-Denis N (2016), Li X (2016)	3
KAT2B	2	NCOA3	3	two hybrid, pull down	Korzus E (1998), Takeshita A (1997)	2
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
MAPK1	1	CSNK2A1	15	enzymatic study, affinity chromatography technology, pull down	Ji H (2009), Ji H (2009), Ji H (2009)	3
TSC1	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Roux PP (2004), Dan HC (2002), Ivanov AA (2017)	3
DUSP16	0	MAPK14	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), Tanoue T (2001), Tanoue T (2001), Masuda K (2001), Bandyopadhyay S (2010), Huttlin EL (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017)	9
CAMKK2	3	OBSL1	9	affinity chromatography technology	Behrends C (2010)	1
CSNK2B	5	BTRC	1	affinity chromatography technology	Tsuchiya Y (2010)	1
MEF2A	1	MAPKAPK3	0	affinity chromatography technology	Li X (2015)	1
RPS6KA5	2	MBP	0	enzymatic study	New L (1999)	1
MAPK11	1	ATF2	1	enzymatic study, enzymatic study	Stein B (1997), Takahashi M (2003)	2
PTPN7	3	MAPK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology	Pettiford SM (2000), Pettiford SM (2000), Saxena M (1999), Chen TC (2014), St-Denis N (2016)	5
FBXW8	2	BTRC	1	affinity chromatography technology	Ponyeam W (2012)	1
ATF2	1	KRT8	3	affinity chromatography technology	Lau E (2012)	1
DUSP1	1	MAPK1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Slack DN (2001), Slack DN (2001), Calvisi DF (2008), Brondello JM (1999), Li X (2016)	5
DUSP10	3	MAPK14	0	two hybrid, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Tanoue T (1999), Tanoue T (2001), Tanoue T (2001), Tanoue T (1999), Tanoue T (2001), Bandyopadhyay S (2010)	6
IQGAP1	1	MAPK3	4	biochemical	Bourguignon LY (2005)	1
AKT1	1	CDKN1A	1	pull down, enzymatic study, imaging technique, enzymatic study	Heron-Milhavet L (2006), Heron-Milhavet L (2006), Chen TC (2014), Roessig L (2001)	4
MAPK14	0	ELMSAN1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2015), Huttlin EL (2017)	3
CBL	7	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erdreich-Epstein A (1997), Shen M (2009), Shen M (2009)	3
RPS6KA5	2	EP300	36	affinity chromatography technology	Janknecht R (2003)	1
MAPK14	0	CIZ1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
MAPKAPK2	1	MAPK3	4	protein complementation assay, enzymatic study	Srivastav RK (2011), Coxon PY (2003)	2
MAPK14	0	SLX4IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RB1	2	CDKN1A	1	affinity chromatography technology, pull down	Nakanishi M (1999), Nakanishi M (1999)	2
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
MAPK11	1	CUL7	4	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	CDC25B	4	enzymatic study, pull down	Bulavin DV (2001), Bulavin DV (2001)	2
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
FBXW8	2	OBSL1	9	affinity chromatography technology	Litterman N (2011)	1
MAP2K6	2	MAPK1	1	enzymatic study	Kumar S (1999)	1
MAPK14	0	NCOA3	3	enzymatic study, enzymatic study	Wu RC (2004), Gianni M (2006)	2
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
MAPK14	0	RECQL4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	TRMT1L	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
MAPK14	0	TPX2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAB1	1	MAPK14	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Ge B (2002), Ge B (2002), Vinayagam A (2011), Ge B (2003), Chen TC (2014), Grimsey NJ (2015)	6
DUSP4	1	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology	Chen P (2001), Cadalbert LC (2010), Li X (2016)	3
MAPK3	4	RPS6KA4	0	affinity chromatography technology	Pierrat B (1998)	1
MAPK14	0	ZNHIT1	0	enzymatic study, two hybrid	Cuadrado A (2007), Wang J (2008)	2
CUL7	4	MAPK1	1	affinity chromatography technology	Hanson D (2014)	1
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
MAPK14	0	FBXW8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA4	0	MAPK1	1	affinity chromatography technology, pull down, pull down	Tomas-Zuber M (2001), Tomas-Zuber M (2001), Smith JA (2000)	3
MAPK14	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
RICTOR	4	IKBKB	1	affinity chromatography technology, pull down	Xu Y (2013), Xu Y (2013)	2
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
MAPK14	0	LRRC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	ERF	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA5	2	MAPK11	1	genetic interference	Deak M (1998)	1
RPS6KA5	2	ATF2	1	imaging technique	Chen TC (2014)	1
SMAD7	1	AKT1	1	affinity chromatography technology	Song K (2006)	1
MAPK11	1	MAPKAPK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Janknecht R (2001), Janknecht R (2001)	3
CSNK2A1	15	HDAC3	5	enzymatic study, affinity chromatography technology	Zhang X (2005), Rajendran P (2011)	2
MEF2A	1	HDAC3	5	affinity chromatography technology	Lee DY (2012)	1
TP53	0	IQGAP1	1	affinity chromatography technology	Fogeron ML (2013)	1
PTPN7	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
MAPK14	0	MEF2D	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2015), Huttlin EL (2017)	3
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
MAPK14	0	DCUN1D5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
MAPK11	1	MKNK1	0	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	HOXB9	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	CDKN1A	1	enzymatic study, affinity chromatography technology	Kim GY (2002), Kim GY (2002)	2
TPX2	4	IKBKB	1	affinity chromatography technology	Irelan JT (2007)	1
MAPK14	0	MAPK14	0	enzymatic study, affinity chromatography technology, enzymatic study	Ge B (2002), Varjosalo M (2013), Tang J (2008)	3
MAPK11	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
SUPT20H	0	MAPK1	1	two hybrid	Wang J (2011)	1
MAPK14	0	DUSP7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK14	0	5616	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP1	1	MAPK3	4	two hybrid, enzymatic study, imaging technique	Slack DN (2001), Brondello JM (1999), Chen TC (2014)	3
HOXA10	1	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Zhu LH (2013), Zhu LH (2013)	2
OBSL1	9	KIF22	1	affinity chromatography technology	Hanson D (2014)	1
MAPK3	4	ATF2	1	imaging technique	Chen TC (2014)	1
MAPK14	0	RPS6KA4	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	10
MAPK14	0	RPS6KA5	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	5
EP300	36	SMAD7	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Groenroos E (2002), Groenroos E (2002), Groenroos E (2002), Groenroos E (2002)	4
TAB1	1	IKBKB	1	affinity chromatography technology	Neil JR (2008)	1
HTRA2	1	MAPK14	0	two hybrid, affinity chromatography technology, enzymatic study	Faccio L (2000), Faccio L (2000), Plun-Favreau H (2007)	3
MAPK14	0	KIF22	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATF2	1	CSNK2A1	15	pull down, far western blotting	Yamaguchi Y (1998), Yamaguchi Y (1998)	2
CSNK2B	5	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
MAPK1	1	ATF2	1	enzymatic study, enzymatic study, enzymatic study	Livingstone C (1995), Sanna MG (2002), Krump E (1997)	3
MAPK14	0	ATF2	1	enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Raingeaud J (1995), Raingeaud J (1995), Chen Z (2001), Pillai VB (2011), Pillai VB (2011), Gianni M (2006), Deacon K (1997), Sudo T (2000), Mo JS (2010), Uddin S (2002), Stein B (1997), Yuan ZQ (2003), Coxon PY (2003), Li H (2001), Sun L (2007), Grimsey NJ (2015), Tang J (2008), Dixon DA (2006), Chen G (2000), Frantz B (1998), Tesker M (2016), Hwang SG (2014), Camps M (1998), Bakin AV (2002), Bulavin DV (1999)	25
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
MAPK1	1	MAPKAPK2	1	affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology	Yannoni YM (2004), Srivastav RK (2011), Powell DW (2003), Krump E (1997)	4
TP53	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andrews P (2006), Andrews P (2006), Andrews P (2006), Dowell JD (2007), Dowell JD (2007), Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Kim SS (2007), Kim SS (2007), Kim SS (2007), Kaustov L (2007), Kasper JS (2006), Kasper JS (2006), Kasper JS (2006), Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017), Guo H (2014)	22
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
TP53	0	ZNHIT1	0	pull down	Cuadrado A (2007)	1
EP300	36	NFKBIA	0	affinity chromatography technology	Shin DH (2009)	1
TP53	0	FBXW8	2	affinity chromatography technology	Li X (2015)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
MAPK14	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
MAP2K3	1	MAPK14	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Chen Z (2001), Casar B (2007), Deacon K (1997), Mo JS (2010), Varjosalo M (2013), Huttlin EL (2015), Li L (2014), Huttlin EL (2017), Ivanov AA (2017)	9
HDAC3	5	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fajas L (2002), Lai A (1999), Lai A (1999), Dahiya A (2000)	4
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
EP300	36	CDT1	2	enzymatic study	Glozak MA (2009)	1
AKT1	1	NFKBIA	0	affinity chromatography technology	Koul D (2001)	1
CDKN1A	1	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Dai M (2012), Dai M (2012)	2
MAPK14	0	PPIL2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL7	4	CIZ1	1	affinity chromatography technology	Hanson D (2014)	1
IKBKB	1	NFKBIA	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Mercurio F (1999), Cohen L (1998), Woronicz JD (1997), Burke JR (2002), Tsuchiya Y (2010), Tsuchiya Y (2010), Da Silva-Ferrada E (2011), Ducut Sigala JL (2004), Heilker R (1999), Edinger RS (2009), Lee FS (1998), Hai T (2006), Zandi E (1998), Henkler F (2003), Li XH (2001), Byun MS (2006), Mauro C (2003), Zhang W (2010), Munzert G (2002), Shibata Y (2012), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Gao H (2004), Hauenstein AV (2014), Fujita H (2014), Zhang J (2013), Chong RA (2014), Dan HC (2008), Sun L (2004), Criollo A (2010), Liu D (2014), Vincendeau M (2016), Zhang L (2015), Zilberman-Rudenko J (2016), Minassian A (2015), Lindstroem TM (2008), Kim BH (2008), Pandey MK (2008), Joo M (2005), Ninomiya-Tsuji J (2003), Chang YJ (2004), Huang WC (2004), Kim EK (2017), Mei ZZ (2016), Shinohara H (2016), Shkoda A (2012)	48
PTPRR	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
OBSL1	9	IQGAP1	1	affinity chromatography technology	Hanson D (2014)	1
HDAC3	5	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
PTPN7	3	MAPK14	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
CSNK2B	5	NFKBIA	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsuchiya Y (2010), Taylor JA (1999), Taylor JA (1999)	3
MAPK14	0	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
IQGAP1	1	MAPK1	1	biochemical, affinity chromatography technology	Bourguignon LY (2005), Bourguignon LY (2005)	2
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
RICTOR	4	AKT1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study	Sarbassov DD (2006), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Woods NT (2012), Kim EK (2011), Chen CH (2011), Garcia-Martinez JM (2009), Chen TC (2014), Pitre A (2012)	10
CSNK2A1	15	SQSTM1	0	enzymatic study, enzymatic study	Matsumoto G (2011), Watanabe Y (2017)	2
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
MEF2A	1	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Luca A (2003), De Luca A (2003), De Luca A (2003), Aude-Garcia C (2010)	4
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
MAPK14	0	DUSP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), Slack DN (2001), Slack DN (2001), Bandyopadhyay S (2010), Chen TC (2014), St-Denis N (2016), Li X (2016)	7
CDC25B	4	KAT2B	2	pull down	Ma ZQ (2001)	1
CAMKK2	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2015), Huttlin EL (2017)	3
SMAD7	1	MAP2K6	2	affinity chromatography technology	Edlund S (2003)	1
MAPK14	0	SUPT20H	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Wang J (2011), Webber JL (2010), Webber JL (2010)	4
MAPK14	0	KRT8	3	enzymatic study, pull down	Ku NO (2002), Ku NO (2002)	2
CBL	7	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
TP53	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai C (2011), Dai C (2011), Dai C (2011), Dai C (2011), Fogeron ML (2013), Hanson D (2014), Hanson D (2014)	7
AKT1	1	MAP2K4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Park HS (2002), Park HS (2002), Park HS (2002), Song JJ (2005), Song JJ (2005)	5
MAPK14	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
MAP2K4	3	MAPK14	0	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Xia Y (1998), Xia Y (1998)	3
MAPKAPK2	1	CDC25B	4	enzymatic study	Manke IA (2005)	1
KAT2B	2	HDAC3	5	pull down, affinity chromatography technology	Gregoire S (2007), Gregoire S (2007)	2
CSNK2B	5	MAPKAPK2	1	protein complementation assay, affinity chromatography technology	Srivastav RK (2011), Srivastav RK (2011)	2
MAPK14	0	RHBDF1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK1	1	NCOA3	3	enzymatic study, enzymatic study	Wu RC (2004), Gianni M (2006)	2
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
AKT1	1	MAPKAPK2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, imaging technique	Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Rane MJ (2001), Wu R (2007), Wu R (2007), Chen TC (2014)	7
PTPN7	3	MAPK3	4	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Pettiford SM (2000), Saxena M (1999), Saxena M (1999), St-Denis N (2016)	4
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
MAPK3	4	DUSP9	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
OBSL1	9	CIZ1	1	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARHGAP9	2	MAPK1	1	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4
SMAD7	1	TAB1	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Yanagisawa M (2001)	2
MAPK14	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
CUL7	4	CSNK2B	5	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	CSNK2A1	15	affinity chromatography technology, pull down	Sayed M (2000), Sayed M (2000)	2
MAPK11	1	TAB1	1	imaging technique	Chen TC (2014)	1
MAPK14	0	CDC25C	0	enzymatic study, pull down	Bulavin DV (2001), Bulavin DV (2001)	2
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IKBKB	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heissmeyer V (2001), Orel L (2010), Tsuchiya Y (2010), Tsuchiya Y (2010)	4
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
CSNK2B	5	RPS6KA5	2	two hybrid	Wang J (2011)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
MAPK1	1	KRT8	3	enzymatic study	Ku NO (2002)	1
MAPK14	0	USP47	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IKBKB	1	TSC1	4	affinity chromatography technology, pull down	Lee DF (2007), Lee DF (2007)	2
MEF2A	1	MEF2D	5	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ornatsky OI (1996), Ornatsky OI (1996), Ornatsky OI (1996), Aude-Garcia C (2010), Li X (2015)	5
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
NCOA3	3	IKBKB	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Wu RC (2002), Jung SY (2005)	7
MAPK11	1	OBSL1	9	affinity chromatography technology	Varjosalo M (2013)	1
MAPK14	0	ARL13B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
MAPK14	0	RNF138	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
DUSP4	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
MAPK11	1	CCDC8	1	affinity chromatography technology	Varjosalo M (2013)	1
CCDC8	1	IQGAP1	1	affinity chromatography technology	Hanson D (2014)	1
CSNK2B	5	CDKN1A	1	pull down	Goetz C (2000)	1
EP300	36	ATF2	1	biochemical	Duyndam MC (1999)	1
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
HDAC3	5	MEF2D	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Gregoire S (2007), Gregoire S (2007), Gregoire S (2007)	3
DUSP4	1	MAPK14	0	pull down, affinity chromatography technology	Chen P (2001), Li X (2016)	2
FBXW8	2	CCDC8	1	affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Hanson D (2014)	2
FBXW8	2	EP300	36	affinity chromatography technology	Kimbrel EA (2009)	1
MAPKAPK2	1	ZFP36L1	1	enzymatic study, enzymatic study	Benjamin D (2006), Maitra S (2008)	2
MAP2K6	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KAT2B	2	HOXB9	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wan J (2016), Wan J (2016), Wan J (2016), Wan J (2016), Wan J (2016)	5
MAPK14	0	MEF2A	1	enzymatic study, enzymatic study	Zhao M (1999), Yang SH (1999)	2