PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KIT	4	PIK3R1	6	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014)	7
SDC2	0	CSF2RA	1	affinity chromatography technology	Modrowski D (2000)	1
KIT	4	CSF2RA	1	imaging technique	Chen TC (2014)	1
CSF2RA	1	PIK3R1	6	affinity chromatography technology	Dhar-Mascareno M (2003)	1
CSF2	2	CSF2RA	1	pull down	Woodcock JM (1994)	1
CSF2RA	1	IKBKB	1	two hybrid, pull down, fluorescent resonance energy transfe, imaging technique	Ebner K (2003), Ebner K (2003), Ebner K (2003), Chen TC (2014)	4
CSF2	2	SDC2	0	pull down	Modrowski D (2000)	1
CSF2RA	1	FATE1	0	two hybrid	Rolland T (2014)	1