PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN11	20	JAK1	6	pull down, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Lehmann U (2003)	3
IL5RA	0	JAK1	6	affinity chromatography technology	Ogata N (1998)	1
LYN	2	PTPN6	0	pull down	Yoshida K (1999)	1
LYN	2	PRKCB	4	affinity chromatography technology	Zhu J (2013)	1
CSF2RB	6	SOCS1	1	affinity chromatography technology	Bunda S (2013)	1
JAK2	1	CSF2RB	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Y (1995), Zhao Y (1995), Brizzi MF (1994), Lei JT (2011)	4
IL5RA	0	JAK2	1	affinity chromatography technology, pull down	Ogata N (1998), Ogata N (1998)	2
RACK1	2	JAK1	6	affinity chromatography technology, pull down, affinity chromatography technology	Usacheva A (2003), Usacheva A (2003), Renga B (2012)	3
KDR	4	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Seo DW (2003)	2
LYN	2	CSF2RB	6	unspecified method, affinity chromatography technology	Adachi T (1999), Li Y (1995)	2
PRKCB	4	IKBKB	1	imaging technique	Chen TC (2014)	1
LYN	2	JAK2	1	pull down	Chin H (1998)	1
PTPN11	20	JAK2	1	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Yin T (1997), Yin T (1997), Tauchi T (1996), Maegawa H (1996)	4
SHC1	0	JAK2	1	pull down, pull down	VanderKuur J (1995), Giordano V (1997)	2
CSF2RB	6	PRKCB	4	affinity chromatography technology	Geijsen N (1999)	1
PRKCB	4	RACK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ron D (1999), Ron D (1999), Chen S (2008), Sato T (2014), Sato T (2014), Sato T (2014)	6
JAK1	6	SOCS1	1	affinity chromatography technology	Park ES (2000)	1
CSF2RB	6	YWHAZ	1	affinity chromatography technology, pull down	Stomski FC (1999), Stomski FC (1999)	2
IL5RA	0	CSF2RB	6	affinity chromatography technology	Ogata N (1998)	1
CSF2RB	6	RACK1	2	two hybrid, affinity chromatography technology, pull down	Geijsen N (1999), Geijsen N (1999), Geijsen N (1999)	3
JAK2	1	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Jiao H (1996), Wu DW (2000)	2
JAK2	1	SOCS1	1	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yasukawa H (1999), Dif F (2001), Endo TA (1997), Endo TA (1997), Endo TA (1997), Yasukawa H (1999), Yasukawa H (1999), Pezet A (1999), Ungureanu D (2002), Masuhara M (1997), Ali S (2003), Monni R (2001), Monni R (2001), Piessevaux J (2008), Yu L (2009), Maruoka M (2017)	16
CSF2RB	6	IKBKB	1	two hybrid	Ebner K (2003)	1
KDR	4	PTPN11	20	two hybrid, affinity chromatography technology, far western blotting	Yao Z (2017), Mitola S (2006), Mitola S (2006)	3
PTPN11	20	PTPN6	0	affinity chromatography technology	Li X (2016)	1
CSF2RB	6	JAK1	6	affinity chromatography technology	Lei JT (2011)	1
CSF2RB	6	MAD2L1	0	affinity chromatography technology, pull down	Takeda M (2001), Takeda M (2001)	2
CSF2RB	6	CSF2RB	6	x-ray crystallography	Carr PD (2001)	1
PTPN6	0	JAK1	6	enzymatic study	Yetter A (1995)	1
SHC1	0	KDR	4	affinity chromatography technology, affinity chromatography technology	Zanetti A (2002), DAngelo G (1999)	2
IL3	1	CSF2RB	6	pull down	Stomski FC (1996)	1
CSF2RB	6	SHC1	0	affinity chromatography technology	Bone H (2000)	1
LYN	2	SHC1	0	affinity chromatography technology	Ptasznik A (1995)	1
CSF2RB	6	PTPN11	20	affinity chromatography technology, pull down	Bone H (1997), Bone H (1997)	2
SOCS1	1	PTPN11	20	affinity chromatography technology	Ali S (2003)	1
CSF2RB	6	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bone H (1997), Bone H (1997), Yi T (1993), Yi T (1993)	4
KDR	4	CSF2RB	6	affinity chromatography technology, affinity chromatography technology	Dentelli P (2005), Dentelli P (2005)	2