PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ACAA2	2	APP	1	pull down	Olah J (2011)	1
CSRP1	0	TALDO1	2	biochemical	Wan C (2015)	1
ESR1	0	ACTN1	5	affinity chromatography technology	Tarallo R (2011)	1
ASCC1	0	TRIP4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
TRIP4	2	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
TES	1	APP	1	affinity chromatography technology	Sala S (2017)	1
TES	1	CSRP1	0	affinity chromatography technology	Sala S (2017)	1
CFL1	0	ACAA2	2	biochemical	Wan C (2015)	1
NUP214	3	CFL1	0	biochemical	Wan C (2015)	1
SUZ12	0	FUBP3	0	affinity chromatography technology	Cao Q (2014)	1
CSRP1	0	CSRP1	0	two hybrid, pull down	Feuerstein R (1994), Feuerstein R (1994)	2
TES	1	ACTN1	5	affinity chromatography technology	Sala S (2017)	1
HSPB1	2	CSRP1	0	biochemical	Wan C (2015)	1
BMI1	0	CSRP1	0	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	CSRP1	0	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
APP	1	CFL1	0	two hybrid	Soler-Lopez M (2011)	1
NUP214	3	CSRP1	0	biochemical	Wan C (2015)	1
ASCC1	0	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
EGFR	5	CSRP1	0	protein complementation assay	Deribe YL (2009)	1
HSPB1	2	TES	1	biochemical, affinity chromatography technology	Wan C (2015), Sala S (2017)	2
CNTRL	5	CSRP1	0	bioid	Gupta GD (2015)	1
ESR1	0	CFL1	0	two hybrid	Arroyo R (2015)	1
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
ASCC2	3	TRIP4	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
ASCC2	3	CSRP1	0	affinity chromatography technology	Knierim E (2016)	1
CSRP1	0	FUBP3	0	biochemical	Wan C (2015)	1
SUZ12	0	CSRP1	0	affinity chromatography technology	Cao Q (2014)	1
GRB2	2	CSRP1	0	affinity chromatography technology	Bisson N (2011)	1
BAG3	4	HSPB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Katsogiannou M (2014), Hein MY (2015)	4
HSPB1	2	ACTN1	5	two hybrid	Katsogiannou M (2014)	1
TES	1	MACF1	12	affinity chromatography technology	Sala S (2017)	1
CFL1	0	UFM1	0	biochemical	Wan C (2015)	1
BAG3	4	GRB2	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
MACF1	12	YBX3	0	biochemical	Kristensen AR (2012)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CFL1	0	CSRP1	0	biochemical	Wan C (2015)	1
CSRP1	0	APP	1	pull down	Olah J (2011)	1
EGFR	5	CFL1	0	protein complementation assay	Deribe YL (2009)	1
ACAA2	2	CSRP1	0	biochemical	Wan C (2015)	1
SUZ12	0	RNF2	1	affinity chromatography technology	Cao Q (2014)	1
SUZ12	0	PRKAR2A	0	affinity chromatography technology	Cao Q (2014)	1
ESR1	0	YBX3	0	affinity chromatography technology	Tarallo R (2011)	1
ESR1	0	CSRP1	0	two hybrid	Arroyo R (2015)	1
RNF2	1	APP	1	affinity chromatography technology	Cao Q (2014)	1
TES	1	ACAA2	2	affinity chromatography technology	Sala S (2017)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
BMI1	0	ACTN1	5	affinity chromatography technology	Cao Q (2014)	1
ESR1	0	TRIP4	2	pull down	Kim HJ (1999)	1
CSRP1	0	YBX3	0	biochemical	Kristensen AR (2012)	1
ESR1	0	SUZ12	0	affinity chromatography technology	Okada M (2015)	1
BMI1	0	YBX3	0	affinity chromatography technology	Cao Q (2014)	1
ACTN1	5	CSRP1	0	pull down	Harper BD (2000)	1
TES	1	CFL1	0	affinity chromatography technology	Sala S (2017)	1
SUZ12	0	YBX3	0	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	YBX3	0	affinity chromatography technology	Cao Q (2014)	1
ASCC1	0	ASCC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Knierim E (2016), Knierim E (2016), Huttlin EL (2017)	4
ESR1	0	HSPB1	2	affinity chromatography technology, pull down	Kanaujiya JK (2013), Nalvarte I (2010)	2
EGFR	5	HSPB1	2	affinity chromatography technology	Li J (2013)	1
ASCC1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology	Yoo HM (2014), Yoo HM (2014)	2
FUBP3	0	APP	1	pull down	Olah J (2011)	1
BAG3	4	CSRP1	0	affinity chromatography technology	Chen Y (2013)	1
CSRP1	0	PRKAR2A	0	biochemical	Kristensen AR (2012)	1
CSRP1	0	MACF1	12	biochemical	Kristensen AR (2012)	1
RNF2	1	FUBP3	0	affinity chromatography technology	Cao Q (2014)	1
UFM1	0	CSRP1	0	biochemical	Wan C (2015)	1