Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ADRA1A 148 ALSEROXYLON CHEMBL1201454 antagonist ChemblInteractions
ADRA1A 148 PHENOXYBENZAMINE HYDROCHLORIDE CHEMBL1200787 antagonist ChemblInteractions
ADRA1A 148 MIRTAZAPINE CHEMBL654 binder DrugBank 10762339, 15771415, 12109911, 3419539
ADRA1A 148 PROMAZINE CHEMBL564 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
ADRA1A 148 DIPIVEFRIN CHEMBL1201262 agonist DrugBank 17658513, 17603545
ADRA1A 148 ERGOTAMINE CHEMBL442 partial agonist DrugBank 17139284, 17016423, 18066532
ADRA1A 148 TOLAZOLINE CHEMBL770 antagonist TdgClinicalTrial, TEND, DrugBank 11938943, 17139284, 17016423, 16368348
ADRA1A 148 ERGOLOID MESYLATES CHEMBL2311030 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2869188
ADRA1A 148 PALIPERIDONE CHEMBL1621 antagonist DrugBank 7691623, 11132243, 15907153, 7531353, 7524043, 15992090, 8925876, 18542932
ADRA1A 148 BEVANTOLOL CHEMBL314010 antagonist DrugBank 1358746
ADRA1A 148 DRONEDARONE CHEMBL184412 antagonist TdgClinicalTrial, TEND, DrugBank 17389667
ADRA1A 148 MIANSERIN CHEMBL6437 antagonist GuideToPharmacologyInteractions, DrugBank
ADRA1A 148 XYLOMETAZOLINE CHEMBL312448 agonist DrugBank 20030735, 8894610
ADRA1A 148 TETRAHYDROZOLINE CHEMBL1266 agonist DrugBank 18259967
ADRA1A 148 BETHANIDINE CHEMBL1201260 TdgClinicalTrial, TEND
ADRA1A 148 LABETALOL HYDROCHLORIDE CHEMBL1200323 antagonist ChemblInteractions
ADRA1A 148 MEPHENTERMINE SULFATE CHEMBL1200996 agonist ChemblInteractions
ADRA1A 148 TETRAHYDROZOLINE HYDROCHLORIDE CHEMBL1200413 agonist ChemblInteractions
ADRA1A 148 THIORIDAZINE CHEMBL479 TdgClinicalTrial, TEND
ADRA1A 148 PSEUDOEPHEDRINE CHEMBL1590 TdgClinicalTrial, TEND
ADRA1A 148 OXYMETAZOLINE CHEMBL762 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 TRAZODONE CHEMBL621 TEND
ADRA1A 148 PHENYLEPHRINE CHEMBL1215 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 SENREBOTASE CHEMBL3137348 TdgClinicalTrial
ADRA1A 148 PHENYLEPHRINE HYDROCHLORIDE CHEMBL1200339 agonist ChemblInteractions
ADRA1A 148 DIPIVEFRIN HYDROCHLORIDE CHEMBL1200833 agonist ChemblInteractions
ADRA1A 148 DABUZALGRON CHEMBL257978 partial agonist, agonist GuideToPharmacologyInteractions, ChemblInteractions
ADRA1A 148 (+)-CYCLAZOSIN CHEMBL2261604 antagonist GuideToPharmacologyInteractions
ADRA1A 148 LISURIDE CHEMBL157138 antagonist GuideToPharmacologyInteractions
ADRA1A 148 PIRIBEDIL (CHEMBL1371770) CHEMBL1371770 antagonist GuideToPharmacologyInteractions
ADRA1A 148 RITANSERIN CHEMBL267777 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL56331 CHEMBL56331 antagonist GuideToPharmacologyInteractions
ADRA1A 148 EPINEPHRINE BITARTRATE CHEMBL1256958 agonist ChemblInteractions
ADRA1A 148 EPINEPHRINE CHEMBL679 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
ADRA1A 148 OXYMETAZOLINE HYDROCHLORIDE CHEMBL1200791 agonist ChemblInteractions
ADRA1A 148 CARVEDILOL PHOSPHATE CHEMBL1201167 antagonist ChemblInteractions
ADRA1A 148 HYDROXYAMPHETAMINE HYDROBROMIDE CHEMBL1200705 agonist ChemblInteractions
ADRA1A 148 DAPIPRAZOLE CHEMBL1201216 antagonist TdgClinicalTrial, TEND, DrugBank 9401944, 17139284, 17016423
ADRA1A 148 LOXAPINE CHEMBL831 binder DrugBank
ADRA1A 148 METHOXAMINE CHEMBL524 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 1680715, 7511752, 8986981, 7875228, 1978244
ADRA1A 148 PROPIOMAZINE CHEMBL1201210 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
ADRA1A 148 FENOLDOPAM CHEMBL588 DrugBank 7670737
ADRA1A 148 BENZPHETAMINE HYDROCHLORIDE CHEMBL3544906 agonist DrugBank 17139284, 17016423
ADRA1A 148 APRACLONIDINE CHEMBL647 agonist DrugBank 17572343, 15937427, 16935593, 17824139, 16921219, 20399934, 18454417
ADRA1A 148 ERGONOVINE CHEMBL119443 agonist DrugBank 2897449, 19933260
ADRA1A 148 LEVOMEPROMAZINE CHEMBL1764 antagonist TdgClinicalTrial, TEND, DrugBank 2870716, 15701205
ADRA1A 148 PARA-METHOXYAMPHETAMINE CHEMBL278663 agonist DrugBank 17139284, 17016423
ADRA1A 148 ACEPROMAZINE CHEMBL39560 antagonist DrugBank 15695070
ADRA1A 148 THIOPROPERAZINE CHEMBL609109 antagonist DrugBank 15695070
ADRA1A 148 CHEMBL609728 CHEMBL609728 DrugBank
ADRA1A 148 DROXIDOPA CHEMBL2103827 agonist ChemblInteractions, DrugBank 17266602, 8825367, 20412040, 9138687, 11482743
ADRA1A 148 CIRAZOLINE CHEMBL13852 agonist DrugBank 8564227, 6123592
ADRA1A 148 RAUWOLFIA SERPENTINA (CHEMBL3559672) CHEMBL3559672 antagonist ChemblInteractions
ADRA1A 148 ALFUZOSIN CHEMBL709 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 ERGOTAMINE TARTRATE CHEMBL2062265 agonist ChemblInteractions
ADRA1A 148 TRIFLUOPERAZINE CHEMBL422 TdgClinicalTrial, TEND
ADRA1A 148 EPHEDRINE CHEMBL211456 TdgClinicalTrial, TEND
ADRA1A 148 ZIPRASIDONE CHEMBL708 TEND
ADRA1A 148 METHAMPHETAMINE CHEMBL1201201 TEND
ADRA1A 148 PHENTOLAMINE MESYLATE CHEMBL1200873 antagonist ChemblInteractions
ADRA1A 148 PHENYLPROPANOLAMINE POLISTIREX CHEMBL1201535 agonist ChemblInteractions
ADRA1A 148 TERAZOSIN HYDROCHLORIDE HYDRATE CHEMBL1201091 antagonist ChemblInteractions
ADRA1A 148 PARDOPRUNOX CHEMBL2103832 TdgClinicalTrial
ADRA1A 148 AMIODARONE CHEMBL633 TdgClinicalTrial, TEND
ADRA1A 148 PHENYLPROPANOLAMINE HYDROCHLORIDE CHEMBL1200695 agonist ChemblInteractions
ADRA1A 148 METHOXAMINE HYDROCHLORIDE CHEMBL1201103 agonist ChemblInteractions
ADRA1A 148 CHEMBL109783 CHEMBL109783 agonist GuideToPharmacologyInteractions
ADRA1A 148 NS-49 CHEMBL72958 agonist GuideToPharmacologyInteractions
ADRA1A 148 DIAZEPAM CHEMBL12 allosteric modulator GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL420060 CHEMBL420060 antagonist GuideToPharmacologyInteractions
ADRA1A 148 A-123189 CHEMBL13856 antagonist GuideToPharmacologyInteractions
ADRA1A 148 BMY-7378 CHEMBL13647 antagonist GuideToPharmacologyInteractions
ADRA1A 148 KETANSERIN CHEMBL51 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL24777 CHEMBL24777 antagonist GuideToPharmacologyInteractions
ADRA1A 148 NIGULDIPINE CHEMBL405355 antagonist GuideToPharmacologyInteractions
ADRA1A 148 UPIDOSIN CHEMBL278865 antagonist GuideToPharmacologyInteractions
ADRA1A 148 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, DrugBank 10227113, 17848919
ADRA1A 148 AMOXAPINE CHEMBL1113 antagonist DrugBank 1966571, 9589848, 6086881
ADRA1A 148 RISPERIDONE CHEMBL85 antagonist GuideToPharmacologyInteractions, DrugBank 7691623, 11132243, 15907153, 15992090, 8925876, 18542932
ADRA1A 148 MEPHENTERMINE CHEMBL1201234 agonist TdgClinicalTrial, TEND, DrugBank 21182601, 10722
ADRA1A 148 LABETALOL CHEMBL429 TdgClinicalTrial, TEND
ADRA1A 148 TEDATIOXETINE CHEMBL2104986 antagonist TdgClinicalTrial, ChemblInteractions
ADRA1A 148 PRAZOSIN CHEMBL2 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 PHENOXYBENZAMINE CHEMBL753 TdgClinicalTrial, TEND
ADRA1A 148 ALFUZOSIN HYDROCHLORIDE CHEMBL1723 agonist, antagonist ChemblInteractions, TTD
ADRA1A 148 MIDODRINE CHEMBL1201212 TdgClinicalTrial, TEND
ADRA1A 148 DOXAZOSIN CHEMBL707 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 BENZPHETAMINE (CHEMBL1201358) CHEMBL1201358 TdgClinicalTrial, TEND
ADRA1A 148 ASENAPINE (CHEMBL3187365) CHEMBL3187365 TdgClinicalTrial
ADRA1A 148 TERAZOSIN CHEMBL611 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 TRIMIPRAMINE MALEATE CHEMBL1200948 antagonist ChemblInteractions
ADRA1A 148 PRAZOSIN HYDROCHLORIDE CHEMBL1558 antagonist ChemblInteractions
ADRA1A 148 TAMSULOSIN HYDROCHLORIDE CHEMBL1200914 antagonist ChemblInteractions
ADRA1A 148 DOXAZOSIN MESYLATE CHEMBL1200561 antagonist ChemblInteractions
ADRA1A 148 INDORAMIN CHEMBL279516 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL1256701 CHEMBL1256701 antagonist GuideToPharmacologyInteractions
ADRA1A 148 ROXINDOLE CHEMBL431367 antagonist GuideToPharmacologyInteractions
ADRA1A 148 SPIPERONE CHEMBL267930 antagonist GuideToPharmacologyInteractions
ADRA1A 148 SPIROXATRINE CHEMBL300555 antagonist GuideToPharmacologyInteractions
ADRA1A 148 TERGURIDE CHEMBL73151 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL25554 CHEMBL25554 antagonist GuideToPharmacologyInteractions
ADRA1A 148 TOLAZOLINE HYDROCHLORIDE CHEMBL1689 antagonist ChemblInteractions
ADRA1A 148 METARAMINOL BITARTRATE CHEMBL2062262 agonist ChemblInteractions
ADRA1A 148 NOREPINEPHRINE CHEMBL1437 agonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 8825367, 9138687, 17266602
ADRA1A 148 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
ADRA1A 148 CLOZAPINE CHEMBL42 antagonist GuideToPharmacologyInteractions, DrugBank 17848919
ADRA1A 148 PHENYLPROPANOLAMINE CHEMBL61006 agonist TdgClinicalTrial, TEND, DrugBank 9164583, 17016423, 15163201, 12163120, 2881994
ADRA1A 148 METARAMINOL CHEMBL1201319 agonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 9663612
ADRA1A 148 FLUPENTIXOL CHEMBL54661 antagonist DrugBank 17139284, 17016423
ADRA1A 148 CARVEDILOL CHEMBL723 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17139284, 17016423
ADRA1A 148 ILOPERIDONE CHEMBL14376 antagonist TdgClinicalTrial, DrugBank 23545936
ADRA1A 148 ALBIFLORIN CHEMBL1939883 DrugBank
ADRA1A 148 ISOMETHEPTENE CHEMBL1697841 agonist DrugBank 15094323, 3129549
ADRA1A 148 NAPHAZOLINE CHEMBL761 agonist DrugBank 10459292, 8930173, 11180982, 16083326, 10481510, 10381812
ADRA1A 148 DEBRISOQUIN CHEMBL169901 TdgClinicalTrial, TEND
ADRA1A 148 NORADRENALINE CHEMBL1356607 agonist ChemblInteractions
ADRA1A 148 NAPHAZOLINE HYDROCHLORIDE CHEMBL1706 agonist ChemblInteractions
ADRA1A 148 PERICIAZINE CHEMBL251940 TdgClinicalTrial, TEND
ADRA1A 148 TAMSULOSIN CHEMBL836 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
ADRA1A 148 LISDEXAMFETAMINE CHEMBL1201222 TdgClinicalTrial, TEND
ADRA1A 148 PHENTOLAMINE CHEMBL597 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions
ADRA1A 148 PHENDIMETRAZINE CHEMBL1744 TdgClinicalTrial, TEND
ADRA1A 148 MIDODRINE HYDROCHLORIDE CHEMBL1200461 agonist ChemblInteractions
ADRA1A 148 NEFAZODONE CHEMBL623 TdgClinicalTrial, TEND
ADRA1A 148 DAPIPRAZOLE HYDROCHLORIDE CHEMBL1201044 antagonist ChemblInteractions
ADRA1A 148 PHENYLEPHRINE BITARTRATE CHEMBL2062264 agonist ChemblInteractions
ADRA1A 148 A-119637 CHEMBL268758 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CYPROHEPTADINE CHEMBL516 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL88272 CHEMBL88272 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CHEMBL179334 CHEMBL179334 antagonist GuideToPharmacologyInteractions
ADRA1A 148 CABERGOLINE CHEMBL1201087 antagonist, binder GuideToPharmacologyInteractions, DrugBank 12388666
ADRA1A 148 ZUCLOPENTHIXOL CHEMBL87385 antagonist DrugBank 12957216
ADRA1A 148 SILODOSIN CHEMBL24778 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 21114397
ADRA1A 148 AMPHETAMINE CHEMBL405 agonist TEND, DrugBank 4399738, 6245760
ADRA1A 148 DROPERIDOL CHEMBL1108 antagonist DrugBank 12505540
ADRA1A 148 NICERGOLINE CHEMBL1372950 antagonist TdgClinicalTrial, TEND, DrugBank 10027088
ADRA1A 148 TIAPRIDE CHEMBL84158 antagonist DrugBank 11520476
ADRA1A 148 SERTINDOLE CHEMBL12713 TdgClinicalTrial, TEND, DrugBank 16925508, 11594443

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADRA1A rs1048101 AA + AG nifedipine efficacy yes This SNP was presented as Arg347Cys. Patients carrying the Cys allele had a better systolic blood pressure reduction as compared to patients homozygous for the Arg allele. A non-significant trend was found for diastolic blood pressure. Genotypes AA + AG are associated with increased response to nifedipine in people with Hypertension as compared to genotype GG. 19444285 1043858918