PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GNG2	0	GNAI2	1	affinity chromatography technology	Stallmeyer B (2017)	1
ADRA2A	0	UCHL1	1	two hybrid, pull down, affinity chromatography technology	Weber B (2009), Weber B (2009), Weber B (2009)	3
ADRA2A	0	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
ADRA2A	0	GNAO1	21	fluorescent resonance energy transfe	Nobles M (2005)	1
ADRA2A	0	ADRA2A	0	fluorescent resonance energy transfe	Nobles M (2005)	1
SNTA1	1	ADRA2A	0	unspecified method	Boisguerin P (2004)	1
GNG2	0	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Lukov GL (2005), Howlett AC (2009), Gales C (2005), Rosskopf D (2003), Zhou JY (2003)	9
GNB1	4	GNAI2	1	fluorescent resonance energy transfe, biochemical	Gibson SK (2006), Havugimana PC (2012)	2
ADRA2A	0	GGA3	6	pull down	Zhang M (2016)	1
ADRA2A	0	GNB1	4	fluorescent resonance energy transfe	Gales C (2005)	1
ADRA2A	0	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
GNAI2	1	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1R9B	1	ADRA2A	0	pull down	Richman JG (2001)	1