PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	WDR48	2	affinity chromatography technology	Emdal KB (2015)	1
MYC	2	SQSTM1	0	affinity chromatography technology	Koch HB (2007)	1
CDH5	2	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lewalle JM (1997), Shasby DM (2002), Huttlin EL (2017)	3
BMI1	0	NXF1	0	affinity chromatography technology	Cao Q (2014)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
ARRB2	5	CTNNA1	7	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
NXF1	0	CTNND1	4	affinity chromatography technology	Castello A (2012)	1
MTMR7	0	CTNND1	4	affinity chromatography technology	Li X (2016)	1
MYC	2	XPO1	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Kirli K (2015)	2
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
CUL3	17	CDC5L	2	affinity chromatography technology	Bennett EJ (2010)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ZBTB33	1	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology	Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011)	3
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
XPO1	8	CSNK1E	0	affinity chromatography technology	Kirli K (2015)	1
AURKA	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kwon YW (2012), Chou CH (2013), Chou CH (2013)	3
PSEN1	11	CTNND1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Tanahashi H (1999), Tanahashi H (1999), Tanahashi H (1999), Shrestha H (2017)	4
IFI16	1	CTNND1	4	affinity chromatography technology	Diner BA (2015)	1
FYN	1	CTNND1	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Martinez MC (2003), Piedra J (2003), Piedra J (2003)	3
IFI16	1	APP	1	pull down	Olah J (2011)	1
BMI1	0	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
CTNNB1	30	SRC	2	affinity chromatography technology	Xi Y (2013)	1
PSEN1	11	CDH2	4	affinity chromatography technology	Maesako M (2010)	1
NTRK1	1	CTNNA1	7	affinity chromatography technology	Emdal KB (2015)	1
ATF2	1	CTTN	1	affinity chromatography technology	Lau E (2012)	1
XPO1	8	CTNND1	4	affinity chromatography technology	Kirli K (2015)	1
APP	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhou F (2012), Zhou F (2012), Olah J (2011)	3
BMI1	0	CTNND1	4	affinity chromatography technology	Cao Q (2014)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
EGFR	5	YES1	1	affinity chromatography technology	Tong J (2014)	1
HNRNPL	3	CTDSPL	1	affinity chromatography technology	Fei T (2017)	1
MUC1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, protein complementation assay, affinity chromatography technology, enzymatic study	Schroeder JA (2001), Li Y (2001), Li Y (2001), Pochampalli MR (2007), Merlin J (2011), Merlin J (2011), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Schroeder JA (2001)	10
SQSTM1	0	CTNND1	4	affinity chromatography technology	Behrends C (2010)	1
PSEN1	11	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tesco G (1998), Kang DE (1999), Murayama M (1998), Prager K (2007), Prager K (2007), Prager K (2007), Serban G (2005), Raurell I (2006), Raurell I (2006)	9
CUL3	17	BMI1	0	affinity chromatography technology	Hernandez-Munoz I (2005)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
EGFR	5	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Tomic S (1995), Keilhack H (1998), Keilhack H (1998), Yao Z (2017)	4
NTRK1	1	G3BP1	4	affinity chromatography technology	Emdal KB (2015)	1
CDH3	3	CTNNA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999)	3
CTNNA3	3	CDH2	4	affinity chromatography technology	Huttlin EL (2017)	1
PTPRJ	5	CTNND1	4	affinity chromatography technology, enzymatic study	Holsinger LJ (2002), Holsinger LJ (2002)	2
CUL3	17	AURKA	1	affinity chromatography technology	Moghe S (2012)	1
NXF1	0	CTNNB1	30	affinity chromatography technology	Castello A (2012)	1
AURKA	1	BTRC	1	affinity chromatography technology	Irelan JT (2007)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
CUL3	17	CTTN	1	affinity chromatography technology	Bennett EJ (2010)	1
CTNNA1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SUMO2	0	ZBTB33	1	pull down	Ouyang J (2009)	1
YES1	1	FYN	1	affinity chromatography technology, affinity chromatography technology	Piedra J (2003), Huttlin EL (2017)	2
CCDC8	1	CTNNA1	7	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
IFI16	1	NXF1	0	affinity chromatography technology	Diner BA (2015)	1
CTDSPL	1	CTNND1	4	bioid	St-Denis N (2016)	1
ERBIN	5	CTNND1	4	pull down	Laura RP (2002)	1
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
EGLN3	0	CTNND1	4	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	CTNNB1	30	affinity chromatography technology	Hein MY (2015)	1
CCDC8	1	VCP	6	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	OTUB1	0	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
GSK3B	1	PSEN1	11	enzymatic study	Prager K (2007)	1
XPO1	8	ARRB2	5	affinity chromatography technology	Kirli K (2015)	1
CTNND1	4	CSNK1E	0	affinity chromatography technology	Del Valle-Perez B (2011)	1
CEP135	2	SQSTM1	0	bioid	Gupta GD (2015)	1
MYC	2	YES1	1	genetic interference	Toyoshima M (2012)	1
MCM2	3	VCP	6	affinity chromatography technology	Drissi R (2015)	1
CTNND1	4	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Shrestha H (2017), Shrestha H (2017)	2
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
CTNND1	4	ACTG1	5	affinity chromatography technology	Martinez MC (2003)	1
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	PPP4R1	3	affinity chromatography technology	Kirli K (2015)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
NTRK1	1	PPP4R1	3	affinity chromatography technology	Emdal KB (2015)	1
SUMO2	0	CTNND1	4	pull down	Ouyang J (2009)	1
MTMR7	0	AURKA	1	affinity chromatography technology	Li X (2016)	1
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
ATF2	1	APP	1	pull down	Olah J (2011)	1
SOX2	4	BMI1	0	affinity chromatography technology	Cox JL (2013)	1
TMEM17	0	ERBIN	5	bioid	Gupta GD (2015)	1
LCK	0	SQSTM1	0	pull down	Joung I (1996)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
CDH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Fischer L (2002), Sadot E (2002), Chung FZ (2014), Boscher C (2008)	6
CCDC8	1	XPO1	8	affinity chromatography technology	Hanson D (2014)	1
TMEM216	0	CTNND1	4	bioid	Gupta GD (2015)	1
LCK	0	CTNND1	4	enzymatic study	Martinez MC (2003)	1
OTUB1	0	CTNND1	4	affinity chromatography technology	Scholz CC (2016)	1
EGLN3	0	ERBIN	5	affinity chromatography technology	Rodriguez J (2016)	1
CTNNA3	3	CDH3	3	affinity chromatography technology	Huttlin EL (2017)	1
G3BP1	4	CDC5L	2	affinity chromatography technology	Jain S (2016)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
ARRB2	5	CTTN	1	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
EGFR	5	CDH2	4	affinity chromatography technology, affinity chromatography technology	Rappl A (2008), Rappl A (2008)	2
MYC	2	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
PLPP3	2	CTNND1	4	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down	Humtsoe JO (2010), Humtsoe JO (2010), Humtsoe JO (2010), Humtsoe JO (2010)	4
EGLN3	0	ZBTB33	1	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	ATF2	1	affinity chromatography technology	Bhoumik A (2008)	1
CUL3	17	KCTD6	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lange S (2012), Rolland T (2014), Smaldone G (2015), Ji AX (2016), Heride C (2016), Huttlin EL (2017)	7
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	CTNNB1	30	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	CTNNB1	30	affinity chromatography technology	Kirli K (2015)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
ARRB2	5	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Luan B (2009), Kim YM (2002), Lee J (2013)	4
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
NXF1	0	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
TMEM17	0	CTNND1	4	bioid	Gupta GD (2015)	1
CTNNA3	3	CTNND1	4	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	CTNND1	4	affinity chromatography technology	Yu CC (2013)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
EGLN3	0	CTNNA1	7	affinity chromatography technology	Rodriguez J (2016)	1
MYC	2	ERBIN	5	affinity chromatography technology	Agrawal P (2010)	1
GSK3B	1	CDH1	4	imaging technique	Chen TC (2014)	1
CUL3	17	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
CDH2	4	CTNND1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Ishiyama N (2010)	3
APP	1	MYC	2	pull down	Virok DP (2011)	1
MCM2	3	ACTG1	5	affinity chromatography technology	Drissi R (2015)	1
ERBIN	5	CTNNB1	30	unspecified method	Boisguerin P (2004)	1
SRC	2	SNCA	0	enzymatic study	Ellis CE (2001)	1
AP2M1	5	CDH3	3	affinity chromatography technology	Li J (2013)	1
CDH1	4	ERBIN	5	bioid	Guo Z (2014)	1
CDH1	4	COL17A1	3	bioid	Guo Z (2014)	1
ATF2	1	CTNNB1	30	affinity chromatography technology	Lau E (2012)	1
LCK	0	G3BP1	4	enzymatic study	Rahmouni S (2005)	1
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
BMI1	0	MUC1	0	pull down	Hiraki M (2016)	1
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
CDH3	3	CTNNB1	30	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999), Ribeiro AS (2013)	4
NTRK1	1	CDH2	4	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	CTNND1	4	affinity chromatography technology	Lleres D (2010)	1
PTPRJ	5	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Tarcic G (2009), Tarcic G (2009)	2
MCM2	3	CTNND1	4	affinity chromatography technology	Drissi R (2015)	1
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
ARRB2	5	CTNND1	4	affinity chromatography technology	Xiao K (2007)	1
PTPN6	0	CTNND1	4	affinity chromatography technology, pull down, affinity chromatography technology	Keilhack H (2000), Keilhack H (2000), Keilhack H (2000)	3
NTRK1	1	CTNND1	4	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	PTPRJ	5	bioid	Guo Z (2014)	1
SQSTM1	0	SNCA	0	imaging technique	Schwarz L (2012)	1
WDR48	2	CTNND1	4	affinity chromatography technology	Sowa ME (2009)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
CCDC8	1	CTNND1	4	affinity chromatography technology	Hanson D (2014)	1
G3BP1	4	APP	1	pull down	Olah J (2011)	1
AP2M1	5	CTNND1	4	affinity chromatography technology	Li J (2013)	1
AURKA	1	IFI16	1	pull down	Kamran M (2017)	1
CDH8	2	CTNND1	4	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
CTNND1	4	KCTD6	2	two hybrid	Rolland T (2014)	1
CCDC8	1	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
EGLN3	0	CTTN	1	affinity chromatography technology	Rodriguez J (2016)	1
MYC	2	ACTG1	5	affinity chromatography technology	Agrawal P (2010)	1
CTNNA1	7	CTTN	1	biochemical	Kristensen AR (2012)	1
VCP	6	CTNNA1	7	affinity chromatography technology	Yu CC (2013)	1
CUL3	17	CTNNB1	30	affinity chromatography technology	Bennett EJ (2010)	1
CDH1	4	YES1	1	pull down	Piedra J (2003)	1
PSEN1	11	CTNNA1	7	affinity chromatography technology	Georgakopoulos A (1999)	1
CTTN	1	BTRC	1	affinity chromatography technology	Zhao J (2012)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
WDR48	2	ZBTB33	1	affinity chromatography technology	Sowa ME (2009)	1
AP2M1	5	CDH1	4	affinity chromatography technology	Li J (2013)	1
CCDC8	1	ACTG1	5	affinity chromatography technology	Hanson D (2014)	1
PTPRM	7	CTNND1	4	affinity chromatography technology, enzymatic study	Zondag GC (2000), Zondag GC (2000)	2
NXF1	0	BTRC	1	affinity chromatography technology	Castello A (2012)	1
EGLN3	0	PPP4R1	3	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
COL17A1	3	CTNND1	4	two hybrid, pull down	Aho S (1999), Aho S (1999)	2
CTTN	1	ACTG1	5	pull down	Uruno T (2001)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
FYN	1	SNCA	0	enzymatic study, enzymatic study, enzymatic study	Nakamura T (2001), Payton JE (2004), Ellis CE (2001)	3
NTRK1	1	CTTN	1	affinity chromatography technology	Emdal KB (2015)	1
PTPRJ	5	CTNNB1	30	affinity chromatography technology	Holsinger LJ (2002)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
XPO1	8	ERBIN	5	affinity chromatography technology	Kirli K (2015)	1
TMEM216	0	APP	1	bioid	Gupta GD (2015)	1
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
MYC	2	CDH5	2	genetic interference	Toyoshima M (2012)	1
CDH5	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lewalle JM (1997), Shasby DM (2002), Margariti A (2010), Cho T (2013), Huttlin EL (2017), Chang CC (2012), Chang CC (2012)	7
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
CDH8	2	PSEN1	11	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	FYN	1	affinity chromatography technology	Hanson D (2014)	1
BTRC	1	BMI1	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2011), Sahasrabuddhe AA (2011)	2
CTNND1	4	CTTN	1	affinity chromatography technology, pull down	Martinez MC (2003), Martinez MC (2003)	2
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
CTNND1	4	SRC	2	affinity chromatography technology	Piedra J (2003)	1
EGFR	5	CTTN	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
MCM2	3	APP	1	pull down	Olah J (2011)	1
CTDSPL	1	EGFR	5	bioid	St-Denis N (2016)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
PLPP3	2	APP	1	pull down	Olah J (2011)	1
BTRC	1	ERBIN	5	bioid, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Xie CM (2015), Xie CM (2015)	3
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
MUC1	0	CTNNB1	30	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yamamoto M (1997), Li Y (2003), Li Y (1998), Li Y (1998), Schroeder JA (2003), Yamamoto M (1997), Li Y (2001), Li Y (2001), Ren J (2002), Li Y (2001), Li Y (2001)	11
CTNND1	4	ZBTB33	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Daniel JM (1999), Daniel JM (1999), Ruzov A (2004), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Dai SD (2010), Dai SD (2010), Kelly KF (2004), Kelly KF (2004), Zhang J (2010), Jiang G (2012), Liu Y (2014)	14
PTPN6	0	LCK	0	enzymatic study, enzymatic study, pull down	Yu CL (2000), Chiang GG (2001), Lorenz U (1994)	3
MYC	2	CSNK1E	0	genetic interference	Toyoshima M (2012)	1
SOX2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cox JL (2013), Xu C (2013), Xu C (2013)	3
RIPK3	2	CTNND1	4	affinity chromatography technology	Li S (2011)	1
CDC5L	2	CTNNA1	7	affinity chromatography technology	Lleres D (2010)	1
FOXB1	1	ZBTB33	1	affinity chromatography technology	Li X (2015)	1
MUC1	0	CTNND1	4	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Li Y (2001), Li Y (2001), Li Y (2001), Li Y (2001)	4
CCDC8	1	SRC	2	affinity chromatography technology	Hanson D (2014)	1
FOXB1	1	CTNNB1	30	affinity chromatography technology	Li X (2015)	1
MYC	2	BTRC	1	affinity chromatography technology, enzymatic study	Popov N (2010), Popov N (2010)	2
PPP4R1	3	CTNND1	4	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
EGFR	5	CDH5	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
SRC	2	PTPN6	0	enzymatic study	Frank C (2004)	1
CUL3	17	ERBIN	5	affinity chromatography technology	Wimuttisuk W (2014)	1
GSK3B	1	MUC1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Li Y (1998), Li Y (1998), Li Y (2001), Li Y (2001)	4
CSNK1E	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
MYC	2	CTNND1	4	affinity chromatography technology	Agrawal P (2010)	1
MUC1	0	SRC	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Li Y (2001), Li Y (2001), Li Y (2001), Li Y (2001), Li Y (2001), Bernier AJ (2011)	6
EGLN3	0	OTUB1	0	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
CDH2	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Straub BK (2003), Wahl JK (2003), Havugimana PC (2012)	3
EGLN3	0	CCDC8	1	affinity chromatography technology	Rodriguez J (2016)	1
BMI1	0	ACTG1	5	affinity chromatography technology	Cao Q (2014)	1
CTDSPL	1	CTNNA1	7	bioid	St-Denis N (2016)	1
SOX2	4	XPO1	8	pull down	Baltus GA (2009)	1
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
CTNND1	4	BTRC	1	affinity chromatography technology, affinity chromatography technology	Shrestha H (2016), Shrestha H (2016)	2
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
CTNNA3	3	CDH1	4	affinity chromatography technology	Huttlin EL (2017)	1
CTNND1	4	YES1	1	affinity chromatography technology, affinity chromatography technology	Piedra J (2003), Piedra J (2003)	2
EGFR	5	CTNND1	4	pull down, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Shrestha H (2016)	7
NTRK1	1	CSNK1E	0	affinity chromatography technology	Emdal KB (2015)	1
G3BP1	4	YES1	1	affinity chromatography technology	Jain S (2016)	1
CTDSPL	1	CCDC8	1	bioid	St-Denis N (2016)	1
SOX2	4	CTNND1	4	affinity chromatography technology	Cox JL (2013)	1
CDH1	4	ACTG1	5	affinity chromatography technology	Hazan RB (1998)	1
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
ATF2	1	CTNND1	4	affinity chromatography technology	Lau E (2012)	1
CTNNA3	3	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Janssens B (2001), Waaijers S (2013), Chen TC (2014), Huttlin EL (2017)	4
CDH5	2	CTNND1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferber A (2002), Lampugnani MG (1997), Huttlin EL (2017)	3
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
CTNND1	4	CDH3	3	affinity chromatography technology, affinity chromatography technology	Reynolds AB (1996), Ribeiro AS (2013)	2
CEP135	2	CTNND1	4	bioid	Gupta GD (2015)	1
CCDC8	1	G3BP1	4	affinity chromatography technology	Hanson D (2014)	1
FYN	1	CDH1	4	affinity chromatography technology, pull down	Piedra J (2003), Piedra J (2003)	2
CDH1	4	PSEN1	11	affinity chromatography technology, affinity chromatography technology	Georgakopoulos A (1999), Serban G (2005)	2
TMEM17	0	SQSTM1	0	bioid	Gupta GD (2015)	1
CCDC8	1	CTNNB1	30	affinity chromatography technology	Hanson D (2014)	1
SNCA	0	CTNND1	4	pull down	Schnack C (2008)	1
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
G3BP1	4	CTNND1	4	affinity chromatography technology	Jain S (2016)	1
CDH8	2	CTNNA1	7	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	SUMO2	0	affinity chromatography technology	Yu CC (2013)	1
EGFR	5	COL17A1	3	affinity chromatography technology	Li J (2013)	1
YES1	1	CTTN	1	affinity chromatography technology	Zhang P (2006)	1
G3BP1	4	VCP	6	affinity chromatography technology	Jain S (2016)	1
HNRNPL	3	PTPRJ	5	affinity chromatography technology	Fei T (2017)	1
MCM2	3	CTNNA1	7	affinity chromatography technology	Drissi R (2015)	1
CTNNA3	3	CTNNA1	7	affinity chromatography technology	Waaijers S (2013)	1
EGFR	5	CTNNA1	7	imaging technique, affinity chromatography technology	Chen TC (2014), Li J (2013)	2
MCM2	3	HNRNPL	3	affinity chromatography technology	Drissi R (2015)	1
AP2M1	5	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CTNND1	4	affinity chromatography technology	Bennett EJ (2010)	1
BTRC	1	CTNNA1	7	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
CDH8	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Kido M (1998), Huttlin EL (2017)	2
HNRNPL	3	CTNND1	4	affinity chromatography technology	Fei T (2017)	1
VCP	6	PLPP3	2	affinity chromatography technology	Mountassif D (2015)	1
ARRB2	5	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
CDH3	3	CDH1	4	affinity chromatography technology, affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000), Klingelhoefer J (2000)	3
GSK3B	1	SNCA	0	pull down	Kawakami F (2011)	1
CCDC8	1	MCM2	3	affinity chromatography technology	Hanson D (2014)	1
CUL3	17	WDR48	2	affinity chromatography technology	Wimuttisuk W (2014)	1
ATP4A	6	CTNND1	4	affinity chromatography technology	Lapierre LA (2007)	1
CTNND1	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FOXB1	1	CTNND1	4	affinity chromatography technology	Li X (2015)	1
HNRNPL	3	ERBIN	5	affinity chromatography technology	Fei T (2017)	1
FYN	1	CTNNB1	30	enzymatic study, imaging technique	Piedra J (2003), Chen TC (2014)	2
OTUB1	0	AURKA	1	enzymatic study	Min M (2015)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
IFI16	1	SQSTM1	0	affinity chromatography technology	Diner BA (2015)	1
ARRB2	5	AP2M1	5	affinity chromatography technology	Boularan C (2007)	1
TMEM17	0	YES1	1	bioid	Gupta GD (2015)	1
AURKA	1	CTNND1	4	affinity chromatography technology	Fogeron ML (2013)	1
CTNNA1	7	CTNND1	4	affinity chromatography technology	Daniel JM (1995)	1
HNRNPL	3	ARRB2	5	affinity chromatography technology	Fei T (2017)	1
MCM2	3	CTNNB1	30	affinity chromatography technology	Drissi R (2015)	1