PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DUSP18	0	PTPN6	0	affinity chromatography technology	St-Denis N (2016)	1
SNX4	0	INSR	9	affinity chromatography technology	Haft CR (1998)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
EGFR	5	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Tomic S (1995), Keilhack H (1998), Keilhack H (1998), Yao Z (2017)	4
INSR	9	DUSP18	0	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
IGF1R	5	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
EPHA7	2	DUSP18	0	two hybrid	Yao Z (2017)	1
ERBB2	6	DUSP18	0	two hybrid	Yao Z (2017)	1
ERBB2	6	PTPN6	0	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
EGFR	5	DUSP18	0	affinity chromatography technology	Yao Z (2017)	1
ERBB4	5	DUSP18	0	two hybrid	Yao Z (2017)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
ROR2	0	DUSP18	0	two hybrid	Yao Z (2017)	1
PTPN6	0	INSR	9	affinity chromatography technology	Uchida T (1994)	1
SNX4	0	EGFR	5	affinity chromatography technology	Haft CR (1998)	1
DUSP18	0	HELZ	6	bioid	St-Denis N (2016)	1
IGF1R	5	DUSP18	0	two hybrid	Yao Z (2017)	1
ERBB3	3	DUSP18	0	two hybrid	Yao Z (2017)	1
EPHA2	3	DUSP18	0	two hybrid	Yao Z (2017)	1
TEK	2	DUSP18	0	two hybrid	Yao Z (2017)	1
DUSP18	0	DCP1A	1	bioid	St-Denis N (2016)	1
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
PTK7	8	PTPN6	0	two hybrid	Yao Z (2017)	1
ERBB2	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	EPHA2	3	affinity chromatography technology	Tong J (2014)	1
EPHA3	5	DUSP18	0	two hybrid	Yao Z (2017)	1
ROR1	2	DUSP18	0	two hybrid	Yao Z (2017)	1
ERBB3	3	PTPN6	0	two hybrid	Yao Z (2017)	1
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
PTK7	8	DUSP18	0	two hybrid	Yao Z (2017)	1
DUSP18	0	GORASP2	1	bioid	St-Denis N (2016)	1
ROR1	2	PTPN6	0	two hybrid	Yao Z (2017)	1
MAPK8IP2	5	DUSP18	0	two hybrid	Grossmann A (2015)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
PTPN6	0	ERBB4	5	enzymatic study, two hybrid	Yao Z (2017), Yao Z (2017)	2
EGFR	5	MAPK8IP2	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
ROR2	0	PTPN6	0	two hybrid	Yao Z (2017)	1
EPHA7	2	EPHA3	5	affinity chromatography technology	Huttlin EL (2017)	1
DUSP18	0	SNX4	0	bioid	St-Denis N (2016)	1
EPHB6	4	DUSP18	0	two hybrid	Yao Z (2017)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
ERBB2	6	MAPK8IP2	5	unspecified method	Jones RB (2006)	1