PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
CSTB	0	CST3	0	enzymatic study	Abrahamson M (1991)	1
PTPN18	1	CTSB	5	affinity chromatography technology	Li X (2016)	1
CTSB	5	BAG6	2	two hybrid	Stelzl U (2005)	1
CDKN1A	1	CTSB	5	two hybrid	Vinayagam A (2011)	1
S100A10	0	ANXA2	0	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Rety S (1999), He KL (2008), He KL (2008), Yang X (2011), Bailleux A (2004), Huttlin EL (2015), Oh YS (2013), Oh YS (2013), Tian W (2008), Tian W (2008), Huttlin EL (2017)	11
FBF1	2	SCLT1	1	bioid	Gupta GD (2015)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPD	3	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
SPRY2	4	SH3KBP1	1	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Haglund K (2005), Haglund K (2005), Haglund K (2005), Rolland T (2014)	4
CTSB	5	CSTA	1	pull down, pull down	Pavlova A (2003), Estrada S (1998)	2
XRN1	4	BAG6	2	two hybrid, affinity chromatography technology	Lehner B (2004), Hein MY (2015)	2
CDKN1A	1	IRS4	2	affinity chromatography technology	Fogeron ML (2013)	1
CDK18	3	APP	1	pull down	Olah J (2011)	1
TRIM25	5	DMWD	3	affinity chromatography technology	Choudhury NR (2017)	1
RPGRIP1L	2	CTSB	5	bioid	Gupta GD (2015)	1
TRIM25	5	CTSB	5	affinity chromatography technology	Choudhury NR (2017)	1
S100A10	0	CTSB	5	two hybrid, pull down	Mai J (2000), Mai J (2000)	2
NR3C1	2	PARP1	3	bioid	Lempiaeinen JK (2017)	1
SPRY2	4	CSTB	0	two hybrid	Vinayagam A (2011)	1
TRIM25	5	ANXA2	0	affinity chromatography technology	Choudhury NR (2017)	1
ANXA7	0	CTSB	5	two hybrid	Vinayagam A (2011)	1
CTSB	5	CSTB	0	pull down, pull down	Pavlova A (2003), Pol E (2001)	2
CTSB	5	PROCR	0	biochemical	Havugimana PC (2012)	1
UNK	3	CTSB	5	affinity chromatography technology	Murn J (2015)	1
EEF1AKMT3	0	CTSB	5	affinity chromatography technology	Cloutier P (2013)	1
CDKN1A	1	BAG6	2	two hybrid, two hybrid	Vinayagam A (2011), Wang J (2011)	2
FBF1	2	CTSB	5	bioid	Gupta GD (2015)	1
CDH1	4	CTSB	5	bioid	Guo Z (2014)	1
SH3KBP1	1	CTSB	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Liu JP (2006), Liu JP (2006), Liu JP (2006)	3
CTSB	5	CST3	0	pull down	Pavlova A (2003)	1
ANXA2	0	APP	1	pull down	Olah J (2011)	1
CDKN1A	1	PARP1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010)	4
XRN1	4	CTSB	5	two hybrid	Lehner B (2004)	1
HNRNPD	3	CTSB	5	two hybrid	Lehner B (2004)	1
IRS4	2	CTSB	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RPGRIP1L	2	SH3KBP1	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
RGS2	2	CTSB	5	two hybrid	Vinayagam A (2011)	1
USP29	2	CTSB	5	affinity chromatography technology	Sowa ME (2009)	1
PTPN18	1	IRS4	2	affinity chromatography technology	St-Denis N (2016)	1
NR3C1	2	CTSB	5	bioid	Lempiaeinen JK (2017)	1
CEP164	6	CTSB	5	bioid	Gupta GD (2015)	1
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
SCLT1	1	CTSB	5	bioid	Gupta GD (2015)	1
HSPB2	1	CTSB	5	two hybrid	Grose JH (2015)	1
STK11	2	APP	1	pull down	Olah J (2011)	1
STK11	2	CTSB	5	two hybrid	Arroyo R (2015)	1
CDH1	4	SH3KBP1	1	bioid	Guo Z (2014)	1
CDH1	4	ANXA2	0	bioid	Guo Z (2014)	1
FAM118B	0	CTSB	5	two hybrid	Vinayagam A (2011)	1
MLH1	6	XRN1	4	affinity chromatography technology	Cannavo E (2007)	1
DMWD	3	CTSB	5	affinity chromatography technology	Sowa ME (2009)	1
CDK18	3	BAG6	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
HNRNPD	3	HSPB2	1	biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Knapinska AM (2011), Knapinska AM (2011), Knapinska AM (2011)	3
EEF1AKMT3	0	BAG6	2	affinity chromatography technology	Cloutier P (2013)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
FBXO6	0	CTSB	5	affinity chromatography technology	Liu B (2012)	1
ANXA7	0	BAG6	2	two hybrid	Vinayagam A (2011)	1
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
CTSB	5	MSI2	1	biochemical	Wan C (2015)	1
PPEF1	1	IRS4	2	affinity chromatography technology	Yadav L (2017)	1
SPRY2	4	CTSB	5	two hybrid	Vinayagam A (2011)	1
ANXA2	0	CTSB	5	pull down	Mai J (2000)	1
FBF1	2	APP	1	pull down	Olah J (2011)	1
MLH1	6	CTSB	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Brieger A (2010), Brieger A (2010), Brieger A (2010)	3
CDH1	4	XRN1	4	bioid	Guo Z (2014)	1
CTSB	5	PARP1	3	enzymatic study	Gobeil S (2001)	1
HIPK4	1	CTSB	5	affinity chromatography technology	Varjosalo M (2013)	1
UBQLN4	2	CTSB	5	two hybrid	Matsuda M (2001)	1
MLH1	6	ANXA2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Brieger A (2010), Brieger A (2010), Brieger A (2010)	3
PPEF1	1	CTSB	5	affinity chromatography technology	Yadav L (2017)	1
TRIM25	5	BAG6	2	affinity chromatography technology	Choudhury NR (2017)	1
CDK18	3	CTSB	5	affinity chromatography technology	Varjosalo M (2013)	1
CTSB	5	APP	1	pull down	Olah J (2011)	1