PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Kreft SG (2003)	2
ELAVL1	0	RNF38	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
RNF38	4	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	RNF114	0	two hybrid, enzymatic study	Markson G (2009), Lin B (2017)	2
UBE2D4	0	TRIM25	5	two hybrid	Markson G (2009)	1
UBE2D4	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2H	3	RNF114	0	two hybrid	Markson G (2009)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	UBE2H	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
UBE2D3	1	DZIP3	6	two hybrid	Markson G (2009)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2D1	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D3	1	DTX3	4	two hybrid	Markson G (2009)	1
TP53	0	RNF38	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Lunardi A (2010), Sheren JE (2013), Sheren JE (2013), Sheren JE (2013)	4
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
DZIP3	6	RNF38	4	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF38	4	two hybrid	Markson G (2009)	1
ZDHHC17	1	RNF38	4	two hybrid	Butland SL (2014)	1
UBE2D1	0	RNF114	0	two hybrid, pull down, enzymatic study	Markson G (2009), Bijlmakers MJ (2011), Lin B (2017)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
LDB1	2	RNF38	4	affinity chromatography technology	Hiratani I (2003)	1
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
RNF114	0	RNF38	4	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	RNF114	0	two hybrid	Markson G (2009)	1
TRIM25	5	RNF38	4	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	RNF38	4	pull down, enzymatic study	Buetow L (2015), Buetow L (2015)	2
UBC	7	RNF114	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Capon F (2008), Fenner BJ (2009), Fenner BJ (2009)	4
UBE2D2	0	RNF38	4	two hybrid, pull down, pull down	Markson G (2009), Sheren JE (2013), Buetow L (2015)	3
UBE2H	3	DZIP3	6	two hybrid	Markson G (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TP63	0	RNF38	4	affinity chromatography technology	Lunardi A (2010)	1
UBE2D2	0	RNF114	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017), Lin B (2017)	4
UBE2D1	0	RNF38	4	two hybrid	Markson G (2009)	1
ELAVL1	0	ZDHHC17	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF38	4	RNF38	4	enzymatic study, enzymatic study	Sheren JE (2013), Buetow L (2015)	2
UBE2H	3	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
ZDHHC17	1	DTX3	4	two hybrid	Butland SL (2014)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TP73	2	RNF38	4	affinity chromatography technology	Lunardi A (2010)	1
UBE2D4	0	DZIP3	6	two hybrid	Markson G (2009)	1
UBE2D3	1	RNF38	4	two hybrid	Markson G (2009)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UBE2H	3	RNF38	4	two hybrid	Markson G (2009)	1
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1