PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB3D	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C9	3	CYP3A4	1	pull down	Subramanian M (2010)	1
MAST1	9	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
POR	1	CYP2C9	3	pull down, pull down	Guengerich FP (1997), Subramanian M (2009)	2
CYP2C9	3	CYP2C19	1	affinity chromatography technology	Huttlin EL (2017)	1
CYP2C9	3	ADGRE5	3	affinity chromatography technology	Huttlin EL (2017)	1
CYP2C9	3	CYP2D6	3	pull down	Subramanian M (2009)	1
POR	1	CYP2C19	1	pull down, pull down	Guengerich FP (1997), Shimada T (2005)	2
MAST1	9	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C9	3	STAT5A	4	two hybrid	Wang J (2011)	1
POR	1	CYP2D6	3	pull down, pull down	Shimada T (2005), Shimada T (2005)	2
ECSIT	3	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
CYP2C18	2	CYP2C9	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	CYP2C9	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAB3D	0	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C9	3	STAMBP	2	two hybrid	Wang J (2011)	1
CYP2C9	3	TOMM40	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
POR	1	CYP3A4	1	pull down, pull down	Shimada T (2005), Shimada T (2005)	2