Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CYP24A1	1591	CHEMBL255088	CHEMBL255088	inhibitor	GuideToPharmacologyInteractions
CYP24A1	1591	LUNACALCIPOL	CHEMBL2105705		TdgClinicalTrial, DrugBank

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CYP24A1	rs2248359	TT	deferasirox	metabolism/PK	not stated	TT (N = 2) had median value of 437.339 µg/ml/h (IQR: 370.35–504.33 µg/ml/h) and TC/CC (N = 7) had 184.892 µg/ml/h (IQR: 147.18–368.51 µg/ml/h).	Genotype TT is associated with metabolism of deferasirox in children with beta-Thalassemia as compared to genotypes CC + CT.	29099735	1449004981
CYP24A1	rs927650	CT + TT	deferasirox	metabolism/PK	yes	Patients with the CT and TT genotype have increased minimum plasma levels (Cmin) as compared to those with the CC genotype. This variant retained statistical significance in regression analyses (p=0.036)	Genotypes CT + TT is associated with decreased metabolism of deferasirox in people with beta-Thalassemia as compared to genotype CC.	29160302	1449157937
CYP24A1	rs3787554	G	calcitriol	efficacy	no	No association was seen with overall survival or progression-free survival. Please note alleles have been complemented to the plus chromosomal strand.	Allele G is not associated with response to calcitriol, cisplatin and docetaxel in people with Carcinoma, Non-Small-Cell Lung as compared to allele A.	23435876	1043858728
CYP24A1	rs2762939	G	calcitriol	efficacy	no	No association was seen with overall survival or progression-free survival.	Allele G is not associated with response to calcitriol, cisplatin and docetaxel in people with Carcinoma, Non-Small-Cell Lung as compared to allele C.	23435876	1043858711
CYP24A1	rs2762939	GG	calcitriol	efficacy	no	The GG genotype was correlated with stable disease and partial response.	Genotype GG is associated with increased response to calcitriol, cisplatin and docetaxel in people with Carcinoma, Non-Small-Cell Lung as compared to genotypes CC + CG.	23435876	982046747
CYP24A1	rs2585428	C	telaprevir	metabolism/PK	yes	Alleles given as A and G. Patients were also treated with ribavirin and PEG interferon, and treatment was for 1 month before trough measurement of S telaprevir enantiomer intracellular levels.	Allele C is associated with decreased trough concentration of telaprevir in people with Hepatitis C as compared to allele T.	26158282	1447990618
CYP24A1	rs2248359	CT + TT	daclatasvir	metabolism/PK	yes		Genotypes CT + TT is associated with increased concentrations of daclatasvir in people with Hepatitis C as compared to genotype CC.	29790402	1449564102
CYP24A1	rs2585428	CT + TT	deferasirox	metabolism/PK	yes	Patients wth the CT and TT genotypes had increased trough concentrations (C0), increased area under the curve (AUC), increased minimum plasma levels (Cmin) and increased half-life levels (t1/2) as compared to those with the CC genotype. Only the association with AUC retained significance in multivariate linear regression analyses (p=0.031). Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CT + TT is associated with decreased metabolism of deferasirox in people with beta-Thalassemia as compared to genotype CC.	29160302	1449157889
CYP24A1	rs2248359	CT + TT	deferasirox	metabolism/PK	yes	Patients with the CT and TT genotype have increased trough concentrations (C0) and increased minimum plasma levels (Cmin) as compared to those with the CC genotype.	Genotypes CT + TT is associated with decreased metabolism of deferasirox in people with beta-Thalassemia as compared to genotype CC.	29160302	1449157896