PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GEM	1	TRIM54	1	two hybrid	Rolland T (2014)	1
OFD1	3	CCDC57	8	bioid	Gupta GD (2015)	1
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
DGCR6L	0	DEUP1	0	two hybrid	Rolland T (2014)	1
DGCR6	0	DEUP1	0	two hybrid	Corominas R (2014)	1
DEUP1	0	MPHOSPH9	1	bioid	Firat-Karalar EN (2014)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
OFD1	3	TXLNA	3	bioid	Gupta GD (2015)	1
ZNF460	4	DEUP1	0	two hybrid	Rolland T (2014)	1
IFIT3	1	DEUP1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CEP192	5	PCNT	10	bioid	Firat-Karalar EN (2014)	1
CEP192	5	CEP131	9	bioid	Firat-Karalar EN (2014)	1
IFT20	0	DEUP1	0	two hybrid, affinity chromatography technology, bioid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Firat-Karalar EN (2014), Huttlin EL (2017)	4
CEP63	2	CSPP1	7	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
DEUP1	0	TXLNB	0	two hybrid	Rolland T (2014)	1
FBF1	2	CEP192	5	bioid	Gupta GD (2015)	1
EXOC5	2	DEUP1	0	two hybrid	Rolland T (2014)	1
PCNT	10	CEP131	9	affinity chromatography technology	Hein MY (2015)	1
DEUP1	0	OFD1	3	bioid	Firat-Karalar EN (2014)	1
KRT15	2	DGCR6L	0	two hybrid	Rual JF (2005)	1
CEP128	1	TXLNA	3	bioid	Gupta GD (2015)	1
ZNF148	4	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	KIAA1671	0	bioid	Firat-Karalar EN (2014)	1
FBF1	2	CSPP1	7	bioid	Gupta GD (2015)	1
DEUP1	0	PRPF4B	3	bioid	Firat-Karalar EN (2014)	1
TXLNA	3	TXLNB	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Li S (2011), Li S (2011), Rolland T (2014), Huttlin EL (2017)	4
CEP152	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP63	2	TXLNB	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
EXOC5	2	BRMS1L	1	two hybrid	Rolland T (2014)	1
CEP63	2	MPHOSPH9	1	bioid	Gupta GD (2015)	1
SUMO1	0	FBF1	2	two hybrid	Rolland T (2014)	1
CEP128	1	MPHOSPH9	1	bioid	Gupta GD (2015)	1
FOXA1	2	SUMO1	0	affinity chromatography technology	Jozwik KM (2016)	1
CEP63	2	CEP131	9	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
DGCR6	0	FBF1	2	two hybrid	Corominas R (2014)	1
CEP152	2	KIAA1671	0	bioid	Gupta GD (2015)	1
DEUP1	0	CEP128	1	bioid	Firat-Karalar EN (2014)	1
SPAG5	1	CCHCR1	2	two hybrid	Rolland T (2014)	1
DEUP1	0	GOLGA3	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OFD1	3	SPAG5	1	bioid	Gupta GD (2015)	1
DEUP1	0	ANXA13	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC85B	0	DEUP1	0	two hybrid	Rual JF (2005)	1
CEP192	5	KIAA1671	0	bioid	Firat-Karalar EN (2014)	1
DGCR6	0	GOLGA2	2	two hybrid	Corominas R (2014)	1
FBF1	2	IFT20	0	two hybrid	Rual JF (2005)	1
CEP128	1	CEP192	5	bioid	Gupta GD (2015)	1
KRT15	2	DEUP1	0	two hybrid	Rolland T (2014)	1
ING5	3	DEUP1	0	two hybrid	Rolland T (2014)	1
ESRRG	2	KIFC3	3	two hybrid	Rolland T (2014)	1
ZNF572	5	DEUP1	0	two hybrid	Rolland T (2014)	1
CCHCR1	2	TFPT	0	affinity chromatography technology	Boldt K (2016)	1
DEUP1	0	CEP63	2	bioid	Firat-Karalar EN (2014)	1
DEUP1	0	CSPP1	7	bioid	Firat-Karalar EN (2014)	1
CEP192	5	CEP152	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
DEUP1	0	SPAG5	1	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Firat-Karalar EN (2014), Huttlin EL (2017)	3
FBF1	2	TXLNA	3	bioid	Gupta GD (2015)	1
DEUP1	0	MAFF	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CEP152	2	PCNT	10	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	CSPP1	7	bioid	Gupta GD (2015)	1
KRT15	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
GOLGA2	2	CSPP1	7	two hybrid	Rolland T (2014)	1
OFD1	3	KIAA1671	0	bioid	Gupta GD (2015)	1
CEP63	2	KIAA1671	0	bioid	Gupta GD (2015)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP63	2	TXLNA	3	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
CEP128	1	KIAA1671	0	bioid	Gupta GD (2015)	1
TRIM54	1	FBF1	2	two hybrid	Rolland T (2014)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
FOXA1	2	DEUP1	0	affinity chromatography technology	Jozwik KM (2016)	1
DEUP1	0	PCNT	10	bioid	Firat-Karalar EN (2014)	1
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
TRAF6	0	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
CEP128	1	CEP131	9	bioid	Gupta GD (2015)	1
OFD1	3	KIFC3	3	affinity chromatography technology	Hein MY (2015)	1
GEM	1	GOLGA2	2	two hybrid	Rolland T (2014)	1
DEUP1	0	CEP131	9	bioid	Firat-Karalar EN (2014)	1
DEUP1	0	CEP85	5	bioid	Firat-Karalar EN (2014)	1
DEUP1	0	CEP192	5	bioid	Firat-Karalar EN (2014)	1
BRMS1L	1	DEUP1	0	two hybrid	Rolland T (2014)	1
TRIM54	1	ZNF572	5	two hybrid	Rolland T (2014)	1
DEUP1	0	MAFG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP128	1	CEP85	5	bioid	Gupta GD (2015)	1
DEUP1	0	TUBG1	2	bioid	Firat-Karalar EN (2014)	1
GEM	1	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	NKTR	6	bioid	Firat-Karalar EN (2014)	1
DEUP1	0	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
CEP192	5	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
KRT15	2	TXLNA	3	two hybrid	Rolland T (2014)	1
CEP192	5	CEP85	5	affinity chromatography technology, bioid	Gomez-Ferreria MA (2012), Firat-Karalar EN (2014)	2
TBC1D22B	2	TRIM54	1	two hybrid	Rolland T (2014)	1
DEUP1	0	TXLNA	3	two hybrid	Rolland T (2014)	1
MAFG	1	MAFF	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEP192	5	OFD1	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
JUN	0	SUMO1	0	protein complementation assay	Fang D (2004)	1
CEP192	5	CEP63	2	bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	3
DEUP1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEUP1	0	TRAF7	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
GOLGA2	2	DEUP1	0	two hybrid	Rolland T (2014)	1
ESRRG	2	DEUP1	0	two hybrid	Rolland T (2014)	1
KIFC3	3	DEUP1	0	two hybrid	Rolland T (2014)	1
TBC1D22B	2	CCDC57	8	two hybrid	Rolland T (2014)	1
DEUP1	0	CCHCR1	2	bioid	Firat-Karalar EN (2014)	1
TRIM54	1	DEUP1	0	two hybrid	Rolland T (2014)	1
CEP63	2	CEP85	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
FBF1	2	CEP131	9	bioid	Gupta GD (2015)	1
AMPH	4	DEUP1	0	two hybrid	Rolland T (2014)	1
CEP63	2	FBF1	2	two hybrid	Rolland T (2014)	1
DEUP1	0	CCDC57	8	bioid	Firat-Karalar EN (2014)	1
EXOC5	2	TXLNB	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	FBF1	2	two hybrid	Rolland T (2014)	1
KIFC3	3	ZNF572	5	two hybrid	Rolland T (2014)	1
KRT15	2	TXLNB	0	two hybrid	Rolland T (2014)	1
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
GOLGA2	2	IFT20	0	two hybrid	Rolland T (2014)	1
OFD1	3	MPHOSPH9	1	bioid	Gupta GD (2015)	1
CCDC85B	0	FBF1	2	two hybrid	Rual JF (2005)	1
GOLGA2	2	ZNF572	5	two hybrid	Rolland T (2014)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
CCHCR1	2	TXLNA	3	two hybrid	Rolland T (2014)	1
TBC1D22B	2	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	HIP1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNT	10	OFD1	3	affinity chromatography technology	Hein MY (2015)	1
OFD1	3	CSPP1	7	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SUMO1	0	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	FAAP100	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
FBF1	2	CEP85	5	bioid	Gupta GD (2015)	1
CEP152	2	TXLNA	3	bioid	Gupta GD (2015)	1
DEUP1	0	DGKH	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	TXLNA	3	two hybrid	Rolland T (2014)	1
CEP63	2	PCNT	10	bioid	Firat-Karalar EN (2014)	1
CEP63	2	CEP152	2	bioid, bioid, bioid, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	4
CCHCR1	2	TXLNB	0	two hybrid	Rolland T (2014)	1
FBF1	2	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	DEUP1	0	two hybrid	Rolland T (2014)	1
OFD1	3	CEP85	5	bioid	Gupta GD (2015)	1
GOLGA2	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
CEP152	2	CEP131	9	bioid	Firat-Karalar EN (2014)	1
DEUP1	0	CEP152	2	bioid	Firat-Karalar EN (2014)	1
TFPT	0	DEUP1	0	two hybrid	Rolland T (2014)	1
DEUP1	0	KNSTRN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEUP1	0	JUN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP152	2	OFD1	3	bioid	Gupta GD (2015)	1