PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
FAM103A1	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
HNRNPL	3	FAM168A	0	affinity chromatography technology	Fei T (2017)	1
ROR2	0	C1orf94	1	two hybrid	Rolland T (2014)	1
DAB1	1	MBNL1	3	two hybrid	Rolland T (2014)	1
DAZAP2	1	POGZ	49	two hybrid	Rolland T (2014)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
APLP1	1	DAB1	1	two hybrid, pull down, affinity chromatography technology	Homayouni R (1999), Homayouni R (1999), Homayouni R (1999)	3
HNRNPL	3	MYO6	3	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	RBFOX2	5	affinity chromatography technology	Fei T (2017)	1
DAB1	1	LGALS9C	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	ROR2	0	affinity chromatography technology	Fei T (2017)	1
SOCS6	0	DAB1	1	pull down	Simo S (2013)	1
ZCCHC10	0	LNX1	7	two hybrid	Rolland T (2014)	1
SH3KBP1	1	INPP5D	2	affinity chromatography technology, two hybrid	Kowanetz K (2004), Conde C (2012)	2
DAB1	1	USP53	1	two hybrid	Rolland T (2014)	1
DAZAP2	1	PRR20A	0	two hybrid	Rolland T (2014)	1
DAB1	1	ARID5A	4	two hybrid	Rolland T (2014)	1
DAB1	1	HMBOX1	2	two hybrid	Rolland T (2014)	1
DAB1	1	APP	1	pull down, pull down	Homayouni R (1999), Olah J (2011)	2
SOCS6	0	LNX1	7	two hybrid	Grossmann A (2015)	1
MAGED1	0	DAZAP2	1	two hybrid	Yu H (2011)	1
RBFOX1	1	DAB1	1	two hybrid	Corominas R (2014)	1
DAB1	1	BHLHE40	5	two hybrid	Rolland T (2014)	1
FAM168A	0	C1orf94	1	two hybrid	Rolland T (2014)	1
ERBB2	6	PIN1	0	affinity chromatography technology	Lam PB (2008)	1
HMBOX1	2	TCEANC	0	two hybrid	Rolland T (2014)	1
DAB1	1	CIART	2	two hybrid	Rolland T (2014)	1
DAB1	1	LNX1	7	two hybrid	Rolland T (2014)	1
DAB1	1	ERBB3	3	unspecified method	Jones RB (2006)	1
MYO6	3	DAB1	1	pull down	Morris SM (2002)	1
C1orf94	1	PRR20A	0	two hybrid	Rolland T (2014)	1
INPP5D	2	DAB1	1	two hybrid	Conde C (2012)	1
TOLLIP	3	RBFOX2	5	two hybrid	Bandyopadhyay S (2010)	1
LRP2	13	DAB1	1	two hybrid, pull down, pull down	Gotthardt M (2000), Gotthardt M (2000), Petersen HH (2003)	3
RBFOX1	1	FAM168A	0	two hybrid	Corominas R (2014)	1
TCEANC	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MAGED1	0	SMAP2	4	two hybrid	Rolland T (2014)	1
DAB1	1	ROR2	0	two hybrid	Rolland T (2014)	1
HMBOX1	2	APP	1	pull down	Olah J (2011)	1
DAB1	1	MAGED1	0	two hybrid	Rolland T (2014)	1
DAB1	1	ZC3H10	1	two hybrid	Rolland T (2014)	1
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
FAM168A	0	PRR20A	0	two hybrid	Rolland T (2014)	1
DAB1	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
DAB1	1	SERF2	0	two hybrid	Rolland T (2014)	1
DAB1	1	PRR20A	0	two hybrid	Rolland T (2014)	1
POGZ	49	PRR20A	0	two hybrid	Rolland T (2014)	1
DAB1	1	HNRNPLL	1	two hybrid	Rolland T (2014)	1
DAB1	1	ZNF488	0	two hybrid	Rolland T (2014)	1
FAM168A	0	NAF1	0	two hybrid	Rolland T (2014)	1
SOCS1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
DAB1	1	MBNL3	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
CDK5	0	APP	1	pull down	Olah J (2011)	1
LRP1	25	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
DAB1	1	TOLLIP	3	two hybrid	Rolland T (2014)	1
DAB1	1	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sato Y (2007), Sato Y (2007), Bior BK (2013)	3
CLASRP	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
VLDLR	3	DAB1	1	two hybrid	Gotthardt M (2000)	1
LRP1	25	DAB1	1	two hybrid, pull down, two hybrid, pull down	Gotthardt M (2000), Gotthardt M (2000), Trommsdorff M (1998), Trommsdorff M (1998)	4
MAGED1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
SOCS3	0	PIN1	0	two hybrid	Stelzl U (2005)	1
ZC3H10	1	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
SOCS7	1	DAB1	1	pull down, enzymatic study	Simo S (2013), Simo S (2013)	2
RBFOX1	1	PRR20A	0	two hybrid	Corominas R (2014)	1
MAGED1	0	ZNF488	0	two hybrid	Rolland T (2014)	1
DAB1	1	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DAZAP2	1	CLASRP	1	two hybrid	Rolland T (2014)	1
DAB1	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
DAB1	1	NAF1	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	ARID5A	4	two hybrid	Rolland T (2014)	1
BHLHE40	5	MAGED1	0	two hybrid	Rolland T (2014)	1
RHOXF2	0	HNRNPLL	1	two hybrid	Rolland T (2014)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
DAB1	1	ZCCHC10	0	two hybrid	Rolland T (2014)	1
SERF2	0	RHOXF2	0	two hybrid	Rual JF (2005)	1
HNRNPL	3	LRP1	25	affinity chromatography technology	Fei T (2017)	1
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ROR2	0	MAGED1	0	affinity chromatography technology	Matsuda T (2003)	1
HNRNPL	3	USP53	1	affinity chromatography technology	Fei T (2017)	1
DAB1	1	LGALS9B	0	two hybrid	Rolland T (2014)	1
CDK5	0	DAB1	1	enzymatic study	Sato Y (2007)	1
DAZAP2	1	FAM168A	0	two hybrid	Rolland T (2014)	1
DAB1	1	APLP2	2	pull down	Homayouni R (1999)	1
DAB1	1	HYAL3	0	two hybrid	Rolland T (2014)	1
RBFOX2	5	MBNL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBNL1	3	APP	1	pull down	Olah J (2011)	1
DAB1	1	PIN1	0	two hybrid	Rolland T (2014)	1
TOLLIP	3	WDYHV1	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	SMAP2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DAB1	1	SMAP2	4	two hybrid	Rolland T (2014)	1
HMBOX1	2	LNX1	7	two hybrid	Rolland T (2014)	1
SIAH1	2	TOLLIP	3	two hybrid	Rolland T (2014)	1
RBFOX1	1	C1orf94	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
MAGED1	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
DAB1	1	POGZ	49	two hybrid	Rolland T (2014)	1
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
TOLLIP	3	PRR20A	0	two hybrid	Rolland T (2014)	1
CIART	2	APP	1	pull down	Olah J (2011)	1
LDLR	4	DAB1	1	two hybrid, pull down	Gotthardt M (2000), Trommsdorff M (1998)	2
DAB1	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	RHOXF2	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Corominas R (2014)	3
DAB1	1	TMTC3	0	two hybrid	Rolland T (2014)	1
LRP8	4	DAB1	1	two hybrid	Gotthardt M (2000)	1
RBFOX2	5	C1orf94	1	two hybrid	Rolland T (2014)	1
ARID5A	4	RHOXF2	0	two hybrid	Rolland T (2014)	1
TOLLIP	3	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
SOCS1	1	DAB1	1	affinity chromatography technology	Feng L (2007)	1
SIAH1	2	WDYHV1	0	two hybrid	Rolland T (2014)	1
ROR2	0	PRR20A	0	two hybrid	Rolland T (2014)	1
CDK6	0	POGZ	49	enzymatic study	Anders L (2011)	1
CDK6	0	DAB1	1	two hybrid	Rolland T (2014)	1
DAB1	1	TCEA2	1	two hybrid	Rolland T (2014)	1
ERBB2	6	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RHOXF2	0	KRTAP19-7	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	BHLHE40	5	two hybrid	Corominas R (2014)	1
TCEA2	1	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	LRP8	4	affinity chromatography technology	Fei T (2017)	1
DAB1	1	ZBTB32	0	two hybrid	Rolland T (2014)	1
SMAP2	4	C1orf94	1	two hybrid	Rolland T (2014)	1
ZCCHC10	0	PIN1	0	two hybrid	Stelzl U (2005)	1
DAB1	1	SNRPB	0	two hybrid	Rolland T (2014)	1
VENTX	1	C1orf94	1	two hybrid	Rolland T (2014)	1
DAB1	1	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
MAGED1	0	C1orf94	1	two hybrid	Rolland T (2014)	1
RHOXF2	0	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
ZBTB32	0	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
PIN1	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
MBNL1	3	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Paul S (2011), Fei T (2017)	2
DAB1	1	STRBP	1	two hybrid	Rolland T (2014)	1
PPIG	1	ZCCHC10	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
TOLLIP	3	BHLHE40	5	two hybrid	Bandyopadhyay S (2010)	1
RBFOX2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
HNRNPL	3	ERBB2	6	affinity chromatography technology	Fei T (2017)	1
ZNF488	0	PRR20A	0	two hybrid	Rolland T (2014)	1
DAB1	1	PPIG	1	two hybrid	Rolland T (2014)	1
SOCS3	0	APP	1	pull down	Olah J (2011)	1
DAB1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
SIAH1	2	ZCCHC10	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	KRTAP19-5	0	two hybrid	Rolland T (2014)	1
DAB1	1	VENTX	1	two hybrid	Rolland T (2014)	1
DAB1	1	TCEANC	0	two hybrid	Rolland T (2014)	1
DAB1	1	SIAH1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid	Park TJ (2003), Park TJ (2003), Park TJ (2003), Park TJ (2003), Park TJ (2003)	5
RBFOX2	5	NAF1	0	two hybrid	Rolland T (2014)	1
ROR2	0	DAZAP2	1	affinity chromatography technology, two hybrid	Winkel A (2008), Rolland T (2014)	2
FAM168A	0	SMAP2	4	two hybrid	Rolland T (2014)	1
DAB1	1	CLASRP	1	two hybrid	Rolland T (2014)	1
DAB1	1	FAM168A	0	two hybrid	Rolland T (2014)	1
DAB1	1	FAM103A1	0	two hybrid	Rolland T (2014)	1
POGZ	49	APP	1	pull down	Olah J (2011)	1
DAB1	1	KRTAP8-1	0	two hybrid	Rolland T (2014)	1
SIAH1	2	PRR20A	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	TOLLIP	3	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MBNL1	3	MBNL3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBFOX1	1	DAZAP2	1	two hybrid	Corominas R (2014)	1
HNRNPL	3	HMBOX1	2	affinity chromatography technology	Fei T (2017)	1
CDK6	0	CLASRP	1	enzymatic study	Anders L (2011)	1
DAB1	1	SIRPB1	6	two hybrid	Rolland T (2014)	1
CLASRP	1	APP	1	pull down	Olah J (2011)	1
SOCS3	0	DAB1	1	affinity chromatography technology	Feng L (2007)	1
HNRNPL	3	DAB1	1	affinity chromatography technology	Fei T (2017)	1
TOLLIP	3	MAGED1	0	affinity chromatography technology	Li S (2011)	1
DAZAP2	1	KRTAP8-1	0	two hybrid	Rolland T (2014)	1
ZC3H10	1	PRR20A	0	two hybrid	Rolland T (2014)	1