PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
EP300	36	CITED4	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Braganca J (2002), Braganca J (2002), Braganca J (2002), Braganca J (2002)	4
EP300	36	TFAP2A	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Braganca J (2003), Braganca J (2003), Shi D (2015)	3
CITED4	0	TFAP2C	4	pull down	Braganca J (2002)	1
TFAP2A	1	TFAP2C	4	affinity chromatography technology	Thewes V (2010)	1
CITED4	0	TFAP2B	2	pull down	Braganca J (2002)	1
TRIM25	5	CITED4	0	affinity chromatography technology	Choudhury NR (2017)	1
TFAP2A	1	TFAP2B	2	affinity chromatography technology	Keyel PA (2008)	1
CITED4	0	TFAP2A	1	pull down	Braganca J (2002)	1